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Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites.

Tuohimaa P, Wang JH, Khan S, Kuuslahti M, Qian K, Manninen T, Auvinen P, Vihinen M, Lou YR.

PLoS One. 2013 Oct 8;8(10):e75338. doi: 10.1371/journal.pone.0075338. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/9cb2000b-a962-453c-ad8b-088f91095f6d.


24R,25-dihydroxyvitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells.

Curtis KM, Aenlle KK, Roos BA, Howard GA.

Mol Endocrinol. 2014 May;28(5):644-58. doi: 10.1210/me.2013-1241. Epub 2014 Mar 5.


25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells.

Lou YR, Laaksi I, Syvälä H, Bläuer M, Tammela TL, Ylikomi T, Tuohimaa P.

FASEB J. 2004 Feb;18(2):332-4. Epub 2003 Dec 4.


C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation.

Kamao M, Tatematsu S, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Ozono K, Kubodera N, Reddy GS, Okano T.

J Biol Chem. 2004 Apr 16;279(16):15897-907. Epub 2004 Feb 2.


Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D.

Flanagan JN, Young MV, Persons KS, Wang L, Mathieu JS, Whitlatch LW, Holick MF, Chen TC.

Anticancer Res. 2006 Jul-Aug;26(4A):2567-72.


Metabolism of vitamin D3 by cytochromes P450.

Sakaki T, Kagawa N, Yamamoto K, Inouye K.

Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. Review.


Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine.

Theodoropoulos C, Demers C, Delvin E, Ménard D, Gascon-Barré M.

Clin Endocrinol (Oxf). 2003 Apr;58(4):489-99.


Evidence that both 1alpha,25-dihydroxyvitamin D3 and 24-hydroxylated D3 enhance human osteoblast differentiation and mineralization.

van Driel M, Koedam M, Buurman CJ, Roelse M, Weyts F, Chiba H, Uitterlinden AG, Pols HA, van Leeuwen JP.

J Cell Biochem. 2006 Oct 15;99(3):922-35.


The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1alpha,25-dihydroxyvitamin D2 as therapeutic agents for prostate cancer.

Chen TC, Schwartz GG, Burnstein KL, Lokeshwar BL, Holick MF.

Clin Cancer Res. 2000 Mar;6(3):901-8.


Isolation and identification of 1alpha-hydroxy-24-oxovitamin D3 and 1alpha,23-dihydroxy-24-oxovitamin D3: metabolites of 1alpha,24(R)-dihydroxyvitamin D3 produced in rat kidney.

Weinstein EA, Rao DS, Siu-Caldera ML, Tserng KY, Uskokovic MR, Ishizuka S, Reddy GS.

Biochem Pharmacol. 1999 Dec 15;58(12):1965-73.


TGFbeta1 regulates 25-hydroxyvitamin D3 1alpha- and 24-hydroxylase activity in cultured growth plate chondrocytes in a maturation-dependent manner.

Pedrozo HA, Boyan BD, Mazock J, Dean DD, Gomez R, Schwartz Z.

Calcif Tissue Int. 1999 Jan;64(1):50-6.


Primary human osteoblasts in response to 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3.

van der Meijden K, Lips P, van Driel M, Heijboer AC, Schulten EA, den Heijer M, Bravenboer N.

PLoS One. 2014 Oct 17;9(10):e110283. doi: 10.1371/journal.pone.0110283. eCollection 2014.


Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells.

Munetsuna E, Kawanami R, Nishikawa M, Ikeda S, Nakabayashi S, Yasuda K, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Mol Cell Endocrinol. 2014 Feb 15;382(2):960-70. doi: 10.1016/j.mce.2013.11.014. Epub 2013 Nov 27.


Effect of 1alpha,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 on metalloproteinase activity and cell maturation in growth plate cartilage in vivo.

Dean DD, Boyan BD, Schwart Z, Muniz OE, Carreno MR, Maeda S, Howell DS.

Endocrine. 2001 Apr;14(3):311-23.


Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

Chow EC, Quach HP, Vieth R, Pang KS.

Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E977-89. doi: 10.1152/ajpendo.00489.2012. Epub 2013 Mar 12.


Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS.

J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789.

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