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Results: 1 to 20 of 103

1.

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.

Henderson CJ, McLaughlin LA, Finn RD, Ronseaux S, Kapelyukh Y, Wolf CR.

Drug Metab Dispos. 2014 Jan;42(1):70-7. doi: 10.1124/dmd.113.055277. Epub 2013 Oct 10.

PMID:
24115751
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

Finn RD, McLaughlin LA, Ronseaux S, Rosewell I, Houston JB, Henderson CJ, Wolf CR.

J Biol Chem. 2008 Nov 14;283(46):31385-93. doi: 10.1074/jbc.M803496200. Epub 2008 Sep 19.

PMID:
18805792
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism.

McLaughlin LA, Ronseaux S, Finn RD, Henderson CJ, Roland Wolf C.

Mol Pharmacol. 2010 Aug;78(2):269-78. doi: 10.1124/mol.110.064246. Epub 2010 Apr 29. Erratum in: Mol Pharmacol. 2014 Jan;85(1)186. Dosage error in article text.

PMID:
20430864
[PubMed - indexed for MEDLINE]
Free Article
4.

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.

Henderson CJ, McLaughlin LA, Wolf CR.

Mol Pharmacol. 2013 Jun;83(6):1209-17. doi: 10.1124/mol.112.084616. Epub 2013 Mar 25.

PMID:
23530090
[PubMed - indexed for MEDLINE]
Free Article
5.

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse.

Pass GJ, Carrie D, Boylan M, Lorimore S, Wright E, Houston B, Henderson CJ, Wolf CR.

Cancer Res. 2005 May 15;65(10):4211-7.

PMID:
15899812
[PubMed - indexed for MEDLINE]
Free Article
6.

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes.

Yamazaki H, Nakano M, Gillam EM, Bell LC, Guengerich FP, Shimada T.

Biochem Pharmacol. 1996 Jul 26;52(2):301-9.

PMID:
8694855
[PubMed - indexed for MEDLINE]
7.

Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.

Peyronneau MA, Renaud JP, Truan G, Urban P, Pompon D, Mansuy D.

Eur J Biochem. 1992 Jul 1;207(1):109-16.

PMID:
1628642
[PubMed - indexed for MEDLINE]
Free Article
8.

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.

Yu LJ, Drewes P, Gustafsson K, Brain EG, Hecht JE, Waxman DJ.

J Pharmacol Exp Ther. 1999 Mar;288(3):928-37.

PMID:
10027828
[PubMed - indexed for MEDLINE]
Free Article
10.

Substrate influence on interaction between cytochrome P450 and cytochrome b5 in microsomes.

Jansson I, Schenkman JB.

Arch Biochem Biophys. 1996 Jan 15;325(2):265-9.

PMID:
8561506
[PubMed - indexed for MEDLINE]
11.

Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity.

Pearce RE, McIntyre CJ, Madan A, Sanzgiri U, Draper AJ, Bullock PL, Cook DC, Burton LA, Latham J, Nevins C, Parkinson A.

Arch Biochem Biophys. 1996 Jul 15;331(2):145-69.

PMID:
8660694
[PubMed - indexed for MEDLINE]
12.

Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5.

Wiercinska P, Squires EJ.

Drug Metab Dispos. 2010 May;38(5):857-62. doi: 10.1124/dmd.109.030528. Epub 2010 Feb 17.

PMID:
20164110
[PubMed - indexed for MEDLINE]
Free Article
13.

The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.

Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K.

Anesthesiology. 1997 Jul;87(1):36-50.

PMID:
9232132
[PubMed - indexed for MEDLINE]
Free Article
14.

Chlorzoxazone hydroxylation in microsomes and hepatocytes from cytochrome P450 oxidoreductase-null mice.

Li L, Porter TD.

J Biochem Mol Toxicol. 2009 Sep-Oct;23(5):357-63. doi: 10.1002/jbt.20299.

PMID:
19827131
[PubMed - indexed for MEDLINE]
15.

Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine.

Zhang QY, Kaminsky LS, Dunbar D, Zhang J, Ding X.

Drug Metab Dispos. 2007 Sep;35(9):1617-23. Epub 2007 Jun 13.

PMID:
17567730
[PubMed - indexed for MEDLINE]
Free Article
16.

A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition.

Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman DJ, Ding X.

J Pharmacol Exp Ther. 2007 Apr;321(1):9-17. Epub 2007 Jan 11.

PMID:
17218484
[PubMed - indexed for MEDLINE]
Free Article
17.

Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes.

Yamazaki H, Nakano M, Imai Y, Ueng YF, Guengerich FP, Shimada T.

Arch Biochem Biophys. 1996 Jan 15;325(2):174-82.

PMID:
8561495
[PubMed - indexed for MEDLINE]
18.

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.

Crewe HK, Barter ZE, Yeo KR, Rostami-Hodjegan A.

Biopharm Drug Dispos. 2011 Sep;32(6):303-18. doi: 10.1002/bdd.760. Epub 2011 Jul 4.

PMID:
21725985
[PubMed - indexed for MEDLINE]
19.

Relationship between hepatic cytochrome P450 3A content and activity and the disposition of midazolam administered orally.

Wandel C, Böcker RH, Böhrer H, deVries JX, Hofmann W, Walter K, Kleingeist B, Neff S, Ding R, Walter-Sack I, Martin E.

Drug Metab Dispos. 1998 Feb;26(2):110-4.

PMID:
9456296
[PubMed - indexed for MEDLINE]
Free Article
20.

Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats.

Shaik IH, Mehvar R.

J Pharm Sci. 2011 Dec;100(12):5281-92. doi: 10.1002/jps.22708. Epub 2011 Jul 20.

PMID:
21780121
[PubMed - indexed for MEDLINE]

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