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Items: 1 to 20 of 91

1.

Genetics. GWAS to therapy by genome edits?

Hardison RC, Blobel GA.

Science. 2013 Oct 11;342(6155):206-7. doi: 10.1126/science.1245813. No abstract available.

2.

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH.

Science. 2013 Oct 11;342(6155):253-7. doi: 10.1126/science.1242088.

3.

Developmental biology. From genetic association to genetic switch.

Michelson AM.

Science. 2008 Dec 19;322(5909):1803-4. doi: 10.1126/science.1169216. No abstract available.

PMID:
19095932
4.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4.

5.

Update on fetal hemoglobin gene regulation in hemoglobinopathies.

Bauer DE, Orkin SH.

Curr Opin Pediatr. 2011 Feb;23(1):1-8. doi: 10.1097/MOP.0b013e3283420fd0. Review.

6.

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus.

Jawaid K, Wahlberg K, Thein SL, Best S.

Blood Cells Mol Dis. 2010 Aug 15;45(2):140-6. doi: 10.1016/j.bcmd.2010.05.006. Epub 2010 Jun 12.

PMID:
20542454
7.

Flicking the switch: adult hemoglobin expression in erythroid cells derived from cord blood and human induced pluripotent stem cells.

Cantú I, Philipsen S.

Haematologica. 2014 Nov;99(11):1647-9. doi: 10.3324/haematol.2014.116483. No abstract available.

8.

Multiple physical stresses induce γ-globin gene expression and fetal hemoglobin production in erythroid cells.

Schaeffer EK, West RJ, Conine SJ, Lowrey CH.

Blood Cells Mol Dis. 2014 Apr;52(4):214-24. doi: 10.1016/j.bcmd.2013.10.007. Epub 2013 Dec 5.

PMID:
24314748
9.

Point mutations or polymorphisms? A sequence analysis of the enhancer 3' to the A gamma-globin gene.

Cohen CJ, Penny L, Forget BG.

Prog Clin Biol Res. 1989;316B:395-401. No abstract available.

PMID:
2482504
10.

MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.

Lulli V, Romania P, Morsilli O, Cianciulli P, Gabbianelli M, Testa U, Giuliani A, Marziali G.

PLoS One. 2013 Apr 4;8(4):e60436. doi: 10.1371/journal.pone.0060436. Print 2013.

11.

[BCL11A controls the expression of the human fetal hemoglobin].

Labie D.

Med Sci (Paris). 2012 Nov;28(11):923-5. doi: 10.1051/medsci/20122811007. Epub 2012 Nov 12. French. No abstract available.

12.

Medicine. Sickle cell disease at 100 years.

Orkin SH, Higgs DR.

Science. 2010 Jul 16;329(5989):291-2. doi: 10.1126/science.1194035. No abstract available.

PMID:
20647458
13.

Fetal globin expression is regulated by Friend of Prmt1.

van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S.

Blood. 2010 Nov 18;116(20):4349-52. doi: 10.1182/blood-2010-03-274399. Epub 2010 Aug 5.

14.

DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobin.

Ottolenghi S, Mantovani R, Nicolis S, Ronchi A, Giglioni B.

Hemoglobin. 1989;13(6):523-41. Review.

PMID:
2481658
15.

[BCL11A represses HbF expression and varies during ontogeny].

Labie D.

Med Sci (Paris). 2009 May;25(5):457-60. doi: 10.1051/medsci/2009255457. French. No abstract available.

16.

Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation.

Calero-Nieto FJ, Wood AD, Wilson NK, Kinston S, Landry JR, Göttgens B.

Nucleic Acids Res. 2010 Oct;38(19):6363-74. doi: 10.1093/nar/gkq490. Epub 2010 Jun 4.

18.

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD.

Blood. 2013 Apr 25;121(17):3493-501. doi: 10.1182/blood-2012-11-466227. Epub 2013 Feb 26.

19.

Pharmacologic manipulation of fetal hemoglobin in the hemoglobinopathies.

Nathan DG.

Ann N Y Acad Sci. 1990;612:179-83. Review. No abstract available.

PMID:
1705406
20.

Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells.

Dutta A, Karkashon S, Raghupathy R, Bhatia H, Tesfa L, Little JA.

Blood Cells Mol Dis. 2011 Feb 15;46(2):125-32. doi: 10.1016/j.bcmd.2010.10.013. Epub 2010 Nov 20.

PMID:
21094617
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