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Items: 1 to 20 of 267

1.

Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells.

Acharya BR, Chatterjee A, Ganguli A, Bhattacharya S, Chakrabarti G.

Biochimie. 2014 Feb;97:78-91. doi: 10.1016/j.biochi.2013.09.025. Epub 2013 Oct 7.

PMID:
24113316
2.

NMK-TD-100, a novel microtubule modulating agent, blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin.

Bhattacharya S, Kumar NM, Ganguli A, Tantak MP, Kumar D, Chakrabarti G.

PLoS One. 2013 Oct 7;8(10):e76286. doi: 10.1371/journal.pone.0076286. eCollection 2013.

3.

AG11, a novel dichloroflavanone derivative with anti-mitotic activity towards human bladder cancer cells.

Juhem A, Boumendjel A, Touquet B, Guillot A, Popov A, Ronot X, Martel-Frachet V.

Anticancer Res. 2013 Oct;33(10):4445-52.

PMID:
24123014
4.

Genistein arrests cell cycle progression of A549 cells at the G(2)/M phase and depolymerizes interphase microtubules through binding to a unique site of tubulin.

Mukherjee S, Acharya BR, Bhattacharyya B, Chakrabarti G.

Biochemistry. 2010 Mar 2;49(8):1702-12. doi: 10.1021/bi901760d.

PMID:
20085293
5.

CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells.

Rai A, Gupta TK, Kini S, Kunwar A, Surolia A, Panda D.

Biochem Pharmacol. 2013 Aug 1;86(3):378-91. doi: 10.1016/j.bcp.2013.05.024. Epub 2013 Jun 6.

PMID:
23747346
6.

A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.

Yan J, Pang Y, Sheng J, Wang Y, Chen J, Hu J, Huang L, Li X.

Biochem Pharmacol. 2015 Sep 1;97(1):51-61. doi: 10.1016/j.bcp.2015.07.008. Epub 2015 Jul 23.

PMID:
26212540
7.

2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules.

Kamath K, Okouneva T, Larson G, Panda D, Wilson L, Jordan MA.

Mol Cancer Ther. 2006 Sep;5(9):2225-33.

8.

Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity.

Acharya BR, Choudhury D, Das A, Chakrabarti G.

Biochemistry. 2009 Jul 28;48(29):6963-74. doi: 10.1021/bi900152k.

PMID:
19527023
9.

Microtubule-disrupting effects of gallium chloride in vitro.

Perchellet EM, Ladesich JB, Collery P, Perchellet JP.

Anticancer Drugs. 1999 Jun;10(5):477-88.

PMID:
10477168
10.

3-(Iodoacetamido)-benzoylurea: a novel cancericidal tubulin ligand that inhibits microtubule polymerization, phosphorylates bcl-2, and induces apoptosis in tumor cells.

Jiang JD, Davis AS, Middleton K, Ling YH, Perez-Soler R, Holland JF, Bekesi JG.

Cancer Res. 1998 Dec 1;58(23):5389-95.

11.

The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.

Prota AE, Danel F, Bachmann F, Bargsten K, Buey RM, Pohlmann J, Reinelt S, Lane H, Steinmetz MO.

J Mol Biol. 2014 Apr 17;426(8):1848-60. doi: 10.1016/j.jmb.2014.02.005. Epub 2014 Feb 11.

PMID:
24530796
12.

Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.

Ling YH, Jiang JD, Holland JF, Perez-Soler R.

Mol Pharmacol. 2002 Sep;62(3):529-38.

13.

Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin.

Choudhury D, Ganguli A, Dastidar DG, Acharya BR, Das A, Chakrabarti G.

Biochimie. 2013 Jun;95(6):1297-309. doi: 10.1016/j.biochi.2013.02.010. Epub 2013 Feb 26.

PMID:
23485682
14.
15.

Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.

Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X.

J Med Chem. 2014 Aug 14;57(15):6364-82. doi: 10.1021/jm500024v. Epub 2014 Jul 25.

PMID:
25061803
16.

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.

Kamal A, Tamboli JR, Nayak VL, Adil SF, Vishnuvardhan MV, Ramakrishna S.

Bioorg Med Chem. 2014 May 1;22(9):2714-23. doi: 10.1016/j.bmc.2014.03.021. Epub 2014 Mar 22.

PMID:
24721832
18.

The natural naphthoquinone plumbagin exhibits antiproliferative activity and disrupts the microtubule network through tubulin binding.

Acharya BR, Bhattacharyya B, Chakrabarti G.

Biochemistry. 2008 Jul 29;47(30):7838-45. doi: 10.1021/bi800730q. Epub 2008 Jul 3.

PMID:
18597479
19.

Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.

Wang F, Yang Z, Liu Y, Ma L, Wu Y, He L, Shao M, Yu K, Wu W, Pu Y, Nie C, Chen L.

Bioorg Med Chem. 2015 Jul 1;23(13):3337-50. doi: 10.1016/j.bmc.2015.04.055. Epub 2015 Apr 24.

PMID:
25937236
20.

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.

Chang LC, Yu YL, Liu CY, Cheng YY, Chou RH, Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC.

Cancer Chemother Pharmacol. 2015 Jun;75(6):1303-15. doi: 10.1007/s00280-015-2765-0. Epub 2015 May 7.

PMID:
25947085
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