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Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma.

Song NR, Lee E, Byun S, Kim JE, Mottamal M, Park JH, Lim SS, Bode AM, Lee HJ, Lee KW, Dong Z.

Cancer Prev Res (Phila). 2013 Dec;6(12):1293-303. doi: 10.1158/1940-6207.CAPR-13-0134. Epub 2013 Oct 8.


CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth.

Lee E, Son JE, Byun S, Lee SJ, Kim YA, Liu K, Kim J, Lim SS, Park JH, Dong Z, Lee KW, Lee HJ.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):12-20. doi: 10.1016/j.taap.2013.04.030. Epub 2013 May 22.


Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf.

Song NR, Kim JE, Park JS, Kim JR, Kang H, Lee E, Kang YG, Son JE, Seo SG, Heo YS, Lee KW.

Int J Mol Sci. 2015 Feb 20;16(3):4453-70. doi: 10.3390/ijms16034453.


Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation.

Albino AP, Juan G, Traganos F, Reinhart L, Connolly J, Rose DP, Darzynkiewicz Z.

Cancer Res. 2000 Aug 1;60(15):4139-45.


Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells.

Seon MR, Park SY, Kwon SJ, Lim SS, Choi HJ, Park H, Lim DY, Kim JS, Lee CH, Kim J, Park JH.

J Nutr Biochem. 2012 Jan;23(1):85-92. doi: 10.1016/j.jnutbio.2010.11.010. Epub 2011 Mar 22.


Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer.

Li Y, Zhao H, Wang Y, Zheng H, Yu W, Chai H, Zhang J, Falck JR, Guo AM, Yue J, Peng R, Yang J.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. doi: 10.1016/j.taap.2013.05.031. Epub 2013 Jun 5.


Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis-diammined dichloridoplatium.

Tang B, Du J, Wang J, Tan G, Gao Z, Wang Z, Wang L.

Oncol Rep. 2012 Apr;27(4):1090-6. doi: 10.3892/or.2011.1580. Epub 2011 Dec 6.


7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase.

Lee DE, Lee KW, Song NR, Seo SK, Heo YS, Kang NJ, Bode AM, Lee HJ, Dong Z.

J Biol Chem. 2010 Jul 9;285(28):21458-66. doi: 10.1074/jbc.M109.094797. Epub 2010 May 5.


Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.

Yaguchi S, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H, Hirono S, Yamazaki K, Yamori T.

J Natl Cancer Inst. 2006 Apr 19;98(8):545-56.


A novel herbal formula induces cell cycle arrest and apoptosis in association with suppressing the PI3K/AKT pathway in human lung cancer A549 cells.

Xiong F, Jiang M, Huang Z, Chen M, Chen K, Zhou J, Yin L, Tang Y, Wang M, Ye L, Zhan Z, Duan J, Fu H, Zhang X.

Integr Cancer Ther. 2014 Mar;13(2):152-60. doi: 10.1177/1534735413503544. Epub 2013 Oct 7.


Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway.

Pramanik KC, Kudugunti SK, Fofaria NM, Moridani MY, Srivastava SK.

Carcinogenesis. 2013 Sep;34(9):2061-70. doi: 10.1093/carcin/bgt154. Epub 2013 May 2.


Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo.

Chen J, Zeng J, Xin M, Huang W, Chen X.

Horm Metab Res. 2011 Sep;43(10):681-6. doi: 10.1055/s-0031-1286306. Epub 2011 Sep 19.


KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.

Hong SW, Jung KH, Park BH, Zheng HM, Lee HS, Choi MJ, Yun JI, Kang NS, Lee J, Hong SS.

Cancer Lett. 2013 May 10;332(1):74-82. doi: 10.1016/j.canlet.2013.01.015. Epub 2013 Jan 21.


[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].

Zhang XJ, Zhang L, Liu YP, Xu HM, Sun P, Song JG, Luo YH.

Zhonghua Zhong Liu Za Zhi. 2013 Mar;35(3):181-6. doi: 10.3760/cma.j.issn.0253-3766.2013.03.005. Chinese.


Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells.

Wang CC, Chiang YM, Sung SC, Hsu YL, Chang JK, Kuo PL.

Cancer Lett. 2008 Jan 18;259(1):82-98. Epub 2007 Nov 19.


Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma.

Yang F, Qian XJ, Qin W, Deng R, Wu XQ, Qin J, Feng GK, Zhu XF.

PLoS One. 2013;8(3):e59879. doi: 10.1371/journal.pone.0059879. Epub 2013 Mar 22.


The novel PI3 kinase inhibitor, BAY 80-6946, impairs melanoma growth in vivo and in vitro.

Schneider P, Schön M, Pletz N, Seitz CS, Liu N, Ziegelbauer K, Zachmann K, Emmert S, Schön MP.

Exp Dermatol. 2014 Aug;23(8):579-84. doi: 10.1111/exd.12470.


Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions.

Huang W, Tang S, Qiao X, Ma W, Ji S, Wang K, Ye M, Yu S.

Fitoterapia. 2014 Apr;94:36-47. doi: 10.1016/j.fitote.2014.01.016. Epub 2014 Jan 30.


Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.

Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T.

PLoS One. 2014 Feb 4;9(2):e87220. doi: 10.1371/journal.pone.0087220. eCollection 2014.

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