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Results: 1 to 20 of 101

1.

Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain.

Burke JR, Liban TJ, Restrepo T, Lee HW, Rubin SM.

J Mol Biol. 2014 Jan 9;426(1):245-55. doi: 10.1016/j.jmb.2013.09.031. Epub 2013 Oct 5.

PMID:
24103329
[PubMed - indexed for MEDLINE]
2.

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

Rubin SM, Gall AL, Zheng N, Pavletich NP.

Cell. 2005 Dec 16;123(6):1093-106.

PMID:
16360038
[PubMed - indexed for MEDLINE]
Free Article
3.

Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding.

Burke JR, Deshong AJ, Pelton JG, Rubin SM.

J Biol Chem. 2010 May 21;285(21):16286-93. doi: 10.1074/jbc.M110.108167. Epub 2010 Mar 11.

PMID:
20223825
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.

Knudsen ES, Wang JY.

Mol Cell Biol. 1997 Oct;17(10):5771-83.

PMID:
9315635
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.

Burke JR, Hura GL, Rubin SM.

Genes Dev. 2012 Jun 1;26(11):1156-66. doi: 10.1101/gad.189837.112. Epub 2012 May 8.

PMID:
22569856
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.

Gorges LL, Lents NH, Baldassare JJ.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1151-60. doi: 10.1152/ajpcell.00300.2008. Epub 2008 Sep 3.

PMID:
18768921
[PubMed - indexed for MEDLINE]
Free Article
7.

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.

Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceño C, Burghammer M, Perrakis A, Marmorstein R, Gamblin SJ.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2363-8. Epub 2003 Feb 21.

PMID:
12598654
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A cyclin D1/cyclin-dependent kinase 4 binding site within the C domain of the retinoblastoma protein.

Pan W, Cox S, Hoess RH, Grafström RH.

Cancer Res. 2001 Apr 1;61(7):2885-91.

PMID:
11306463
[PubMed - indexed for MEDLINE]
Free Article
11.

Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites.

Knudsen ES, Wang JY.

J Biol Chem. 1996 Apr 5;271(14):8313-20.

PMID:
8626527
[PubMed - indexed for MEDLINE]
Free Article
12.

Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket.

Whitaker LL, Su H, Baskaran R, Knudsen ES, Wang JY.

Mol Cell Biol. 1998 Jul;18(7):4032-42.

PMID:
9632788
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis.

Shen WH, Yin Y, Broussard SR, McCusker RH, Freund GG, Dantzer R, Kelley KW.

J Biol Chem. 2004 Feb 27;279(9):7438-46. Epub 2003 Dec 16.

PMID:
14681231
[PubMed - indexed for MEDLINE]
Free Article
14.

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H.

Mol Cell Biol. 1994 Dec;14(12):8420-31.

PMID:
7969176
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

Welch PJ, Wang JY.

Genes Dev. 1995 Jan 1;9(1):31-46.

PMID:
7828850
[PubMed - indexed for MEDLINE]
Free Article
16.

The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth.

Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K, Xiao ZX.

J Biol Chem. 2004 Dec 17;279(51):53317-22. Epub 2004 Oct 13.

PMID:
15485814
[PubMed - indexed for MEDLINE]
Free Article
17.

Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.

Suryadinata R, Sadowski M, Steel R, Sarcevic B.

J Biol Chem. 2011 Feb 18;286(7):5108-18. doi: 10.1074/jbc.M110.198473. Epub 2010 Dec 9.

PMID:
21148318
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

Sellers WR, Rodgers JW, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11544-8.

PMID:
8524800
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1.

Watanabe G, Albanese C, Lee RJ, Reutens A, Vairo G, Henglein B, Pestell RG.

Mol Cell Biol. 1998 Jun;18(6):3212-22.

PMID:
9584162
[PubMed - indexed for MEDLINE]
Free PMC Article

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