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A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells.

Kim DH, Hossain MA, Kim MY, Kim JA, Yoon JH, Suh HS, Kim GY, Choi YH, Chung HY, Kim ND.

Int J Oncol. 2013 Dec;43(6):1915-24. doi: 10.3892/ijo.2013.2116. Epub 2013 Oct 2.


Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.

Jung DB, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Kim YC, Ahn KS, Chen CY, Kim SH.

Biol Pharm Bull. 2011;34(6):850-5.


A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells.

Manohar SM, Padgaonkar AA, Jalota-Badhwar A, Sonawane V, Rathos MJ, Kumar S, Joshi KS.

BMC Cancer. 2011 Aug 5;11:338. doi: 10.1186/1471-2407-11-338.


Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells.

Alqawi O, Moghaddas M, Singh G.

Prostate Cancer Prostatic Dis. 2006;9(2):126-35. Epub 2006 Jan 24.


Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells.

Cho SY, Lee HJ, Jeong SJ, Lee HJ, Kim HS, Chen CY, Lee EO, Kim SH.

J Pineal Res. 2011 Aug;51(1):87-93. doi: 10.1111/j.1600-079X.2011.00865.x. Epub 2011 Mar 11.


Aromatic hydrocarbon receptor inhibits lysophosphatidic acid-induced vascular endothelial growth factor-A expression in PC-3 prostate cancer cells.

Wu PY, Lin YC, Lan SY, Huang YL, Lee H.

Biochem Biophys Res Commun. 2013 Aug 2;437(3):440-5. doi: 10.1016/j.bbrc.2013.06.098. Epub 2013 Jul 3.


Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.

Takata K, Morishige K, Takahashi T, Hashimoto K, Tsutsumi S, Yin L, Ohta T, Kawagoe J, Takahashi K, Kurachi H.

Mol Cancer Ther. 2008 Jun;7(6):1551-61. doi: 10.1158/1535-7163.MCT-07-0428.


Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells.

Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC, Pelling JC.

Mol Carcinog. 2008 Sep;47(9):686-700. doi: 10.1002/mc.20421.


Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.

Chen MC, Lee CF, Huang WH, Chou TC.

Biochem Pharmacol. 2013 May 1;85(9):1278-87. doi: 10.1016/j.bcp.2013.02.009. Epub 2013 Feb 14.


Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.

Shin J, Lee HJ, Jung DB, Jung JH, Lee HJ, Lee EO, Lee SG, Shim BS, Choi SH, Ko SG, Ahn KS, Jeong SJ, Kim SH.

PLoS One. 2011;6(6):e21492. doi: 10.1371/journal.pone.0021492. Epub 2011 Jun 24.


HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs).

De Francesco EM, Lappano R, Santolla MF, Marsico S, Caruso A, Maggiolini M.

Breast Cancer Res. 2013;15(4):R64.


Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.

Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Simioni C, Leung E, Maclennan S, Baraldi PG, Borea PA.

Mol Pharmacol. 2007 Aug;72(2):395-406. Epub 2007 May 8.


Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells.

Shin JM, Jeong YJ, Cho HJ, Park KK, Chung IK, Lee IK, Kwak JY, Chang HW, Kim CH, Moon SK, Kim WJ, Choi YH, Chang YC.

PLoS One. 2013 Jul 23;8(7):e69380. doi: 10.1371/journal.pone.0069380. Print 2013.


Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1α and induces G2/M arrest under hypoxia in prostate cancer cells.

Manohar SM, Padgaonkar AA, Jalota-Badhwar A, Rao SV, Joshi KS.

Prostate Cancer Prostatic Dis. 2012 Mar;15(1):15-27. doi: 10.1038/pcan.2011.51. Epub 2011 Nov 15.


Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3.

Boreddy SR, Sahu RP, Srivastava SK.

PLoS One. 2011;6(10):e25799. doi: 10.1371/journal.pone.0025799. Epub 2011 Oct 10.


1,2,3,4,6-Penta-O-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells.

Park KY, Lee HJ, Jeong SJ, Lee HJ, Kim HS, Kim SH, Lim S, Kim HC, Lü J, Kim SH.

Biol Pharm Bull. 2010;33(11):1835-40.


Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDF.

Bao B, Ahmad A, Kong D, Ali S, Azmi AS, Li Y, Banerjee S, Padhye S, Sarkar FH.

PLoS One. 2012;7(8):e43726. doi: 10.1371/journal.pone.0043726. Epub 2012 Aug 27.

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