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Results: 1 to 20 of 101

1.

Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.

Tan YX, Zikherman J, Weiss A.

Cold Spring Harb Symp Quant Biol. 2013;78:131-9. doi: 10.1101/sqb.2013.78.020347. Epub 2013 Oct 7.

PMID:
24100586
[PubMed - in process]
Free PMC Article
2.

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A.

Immunity. 2010 Mar 26;32(3):342-54. doi: 10.1016/j.immuni.2010.03.006.

PMID:
20346773
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.

Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A.

Sci Signal. 2011 Sep 13;4(190):ra59. doi: 10.1126/scisignal.2001893.

PMID:
21917715
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.

Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A.

Nat Immunol. 2014 Feb;15(2):186-94. doi: 10.1038/ni.2772. Epub 2013 Dec 8.

PMID:
24317039
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

In vitro membrane reconstitution of the T-cell receptor proximal signaling network.

Hui E, Vale RD.

Nat Struct Mol Biol. 2014 Feb;21(2):133-42. doi: 10.1038/nsmb.2762. Epub 2014 Jan 26.

PMID:
24463463
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase.

Cloutier JF, Veillette A.

J Exp Med. 1999 Jan 4;189(1):111-21.

PMID:
9874568
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

Schmedt C, Tarakhovsky A.

J Exp Med. 2001 Apr 2;193(7):815-26.

PMID:
11283154
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.

Chong YP, Mulhern TD, Cheng HC.

Growth Factors. 2005 Sep;23(3):233-44. Review.

PMID:
16243715
[PubMed - indexed for MEDLINE]
9.

Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.

Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T.

J Biol Chem. 2011 Jun 24;286(25):22101-12. doi: 10.1074/jbc.M110.196733. Epub 2011 May 4.

PMID:
21543337
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.

Palacios EH, Weiss A.

Oncogene. 2004 Oct 18;23(48):7990-8000. Review.

PMID:
15489916
[PubMed - indexed for MEDLINE]
11.

Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.

Davidson D, Bakinowski M, Thomas ML, Horejsi V, Veillette A.

Mol Cell Biol. 2003 Mar;23(6):2017-28.

PMID:
12612075
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

CSK associates with the TCR zeta and epsilon chains via its SH2 domain; a mechanism for turning off TCR signaling.

Catipović B.

Lijec Vjesn. 1996 Nov-Dec;118(11-12):264-71.

PMID:
9172452
[PubMed - indexed for MEDLINE]
13.

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

Secrist JP, Burns LA, Karnitz L, Koretzky GA, Abraham RT.

J Biol Chem. 1993 Mar 15;268(8):5886-93.

PMID:
8383678
[PubMed - indexed for MEDLINE]
Free Article
14.

Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling.

Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K.

J Biol Chem. 2003 May 16;278(20):17597-600. Epub 2003 Mar 28.

PMID:
12665526
[PubMed - indexed for MEDLINE]
Free Article
15.

Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells.

Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K.

Eur J Immunol. 2004 Aug;34(8):2191-9.

PMID:
15259016
[PubMed - indexed for MEDLINE]
16.

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

Stone JD, Conroy LA, Byth KF, Hederer RA, Howlett S, Takemoto Y, Holmes N, Alexander DR.

J Immunol. 1997 Jun 15;158(12):5773-82.

PMID:
9190928
[PubMed - indexed for MEDLINE]
17.

The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.

Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A.

EMBO J. 1994 Sep 1;13(17):4002-10.

PMID:
8076596
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A.

EMBO J. 1996 Nov 15;15(22):6251-61.

PMID:
8947048
[PubMed - indexed for MEDLINE]
Free PMC Article
19.
20.

Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling.

He X, Woodford-Thomas TA, Johnson KG, Shah DD, Thomas ML.

Eur J Immunol. 2002 Sep;32(9):2578-87.

PMID:
12207342
[PubMed - indexed for MEDLINE]
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