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Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.

Wiesner D, Merdian I, Lewerenz J, Ludolph AC, Dupuis L, Witting A.

PLoS One. 2013 Oct 3;8(10):e76670. doi: 10.1371/journal.pone.0076670. eCollection 2013.


Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1α in amyotrophic lateral sclerosis.

Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, Kikuchi H, Iinuma KM, Tanaka M, Iwaki T, Matsushita T, Ohyagi Y, Kira J.

Brain Pathol. 2013 Sep;23(5):534-46. doi: 10.1111/bpa.12040. Epub 2013 Mar 1.


NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

Kim TH, Hur EG, Kang SJ, Kim JA, Thapa D, Lee YM, Ku SK, Jung Y, Kwak MK.

Cancer Res. 2011 Mar 15;71(6):2260-75. doi: 10.1158/0008-5472.CAN-10-3007. Epub 2011 Jan 28.


Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models.

Vargas MR, Burton NC, Kutzke J, Gan L, Johnson DA, Schäfer M, Werner S, Johnson JA.

PLoS One. 2013;8(2):e56625. doi: 10.1371/journal.pone.0056625. Epub 2013 Feb 13. Erratum in: PLoS One. 2013;8(4). doi:10.1371/annotation/28f68b10-e23d-4519-8d52-8cc94fe372b1. Kutzke, Jennifer [added].


Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis.

Benkler C, Ben-Zur T, Barhum Y, Offen D.

Glia. 2013 Mar;61(3):312-26. doi: 10.1002/glia.22428. Epub 2012 Dec 22.


Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R.

Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386.


Impaired response of hypoxic sensor protein HIF-1α and its downstream proteins in the spinal motor neurons of ALS model mice.

Sato K, Morimoto N, Kurata T, Mimoto T, Miyazaki K, Ikeda Y, Abe K.

Brain Res. 2012 Sep 14;1473:55-62. doi: 10.1016/j.brainres.2012.07.040. Epub 2012 Jul 31.


Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients.

Moreau C, Gosset P, Kluza J, Brunaud-Danel V, Lassalle P, Marchetti P, Defebvre L, Destée A, Devos D.

Neuroscience. 2011 Jan 13;172:110-7. doi: 10.1016/j.neuroscience.2010.10.040. Epub 2010 Oct 25.


The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model.

Guo Y, Zhang Y, Wen D, Duan W, An T, Shi P, Wang J, Li Z, Chen X, Li C.

Lab Invest. 2013 Jul;93(7):825-33. doi: 10.1038/labinvest.2013.73. Epub 2013 May 27.


Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein.

Choi YK, Kim CK, Lee H, Jeoung D, Ha KS, Kwon YG, Kim KW, Kim YM.

J Biol Chem. 2010 Oct 15;285(42):32116-25. doi: 10.1074/jbc.M110.131284. Epub 2010 Aug 19.


Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

Miquel E, Cassina A, Martínez-Palma L, Bolatto C, Trías E, Gandelman M, Radi R, Barbeito L, Cassina P.

PLoS One. 2012;7(4):e34776. doi: 10.1371/journal.pone.0034776. Epub 2012 Apr 3.


VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.

Mali Y, Zisapel N.

Neurobiol Dis. 2010 Mar;37(3):673-81. doi: 10.1016/j.nbd.2009.12.005. Epub 2009 Dec 16.


Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1α-mediated target gene activation.

Brix B, Mesters JR, Pellerin L, Jöhren O.

J Neurosci. 2012 Jul 11;32(28):9727-35. doi: 10.1523/JNEUROSCI.0879-12.2012.


Linking hypoxic and oxidative insults to cell death mechanisms in models of ALS.

Xu R, Wu C, Zhang X, Zhang Q, Yang Y, Yi J, Yang R, Tao Y.

Brain Res. 2011 Feb 4;1372:133-44. doi: 10.1016/j.brainres.2010.11.056. Epub 2010 Nov 25.


Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.

Neymotin A, Calingasan NY, Wille E, Naseri N, Petri S, Damiano M, Liby KT, Risingsong R, Sporn M, Beal MF, Kiaei M.

Free Radic Biol Med. 2011 Jul 1;51(1):88-96. doi: 10.1016/j.freeradbiomed.2011.03.027. Epub 2011 Mar 30.


Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.

Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J, Shaw PJ.

Brain. 2011 Sep;134(Pt 9):2627-41. doi: 10.1093/brain/awr193.

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