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Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro.

Chen J, Lee EJ, Jing L, Christoforou N, Leong KW, Setton LA.

PLoS One. 2013 Sep 25;8(9):e75548. doi: 10.1371/journal.pone.0075548. eCollection 2013.


Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype.

Korecki CL, Taboas JM, Tuan RS, Iatridis JC.

Stem Cell Res Ther. 2010 Jun 16;1(2):18. doi: 10.1186/scrt18.


Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration.

Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FW.

Arthritis Res Ther. 2011;13(6):R215. doi: 10.1186/ar3548. Epub 2011 Dec 29.


Modulating notochordal differentiation of human induced pluripotent stem cells using natural nucleus pulposus tissue matrix.

Liu Y, Rahaman MN, Bal BS.

PLoS One. 2014 Jul 23;9(7):e100885. doi: 10.1371/journal.pone.0100885. eCollection 2014.


Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells.

Purmessur D, Schek RM, Abbott RD, Ballif BA, Godburn KE, Iatridis JC.

Arthritis Res Ther. 2011 May 31;13(3):R81. doi: 10.1186/ar3344.


Native nucleus pulposus tissue matrix promotes notochordal differentiation of human induced pluripotent stem cells with potential for treating intervertebral disc degeneration.

Liu Y, Fu S, Rahaman MN, Mao JJ, Bal BS.

J Biomed Mater Res A. 2015 Mar;103(3):1053-9. doi: 10.1002/jbm.a.35243. Epub 2014 Jun 17.


Nucleus pulposus degeneration alters properties of resident progenitor cells.

Mizrahi O, Sheyn D, Tawackoli W, Ben-David S, Su S, Li N, Oh A, Bae H, Gazit D, Gazit Z.

Spine J. 2013 Jul;13(7):803-14. doi: 10.1016/j.spinee.2013.02.065. Epub 2013 Apr 9.


Canine notochordal cell-secreted factors protect murine and human nucleus pulposus cells from apoptosis by inhibition of activated caspase-9 and caspase-3/7.

Mehrkens A, Karim MZ, Kim S, Hilario R, Fehlings MG, Erwin WM.

Evid Based Spine Care J. 2013 Oct;4(2):154-6. doi: 10.1055/s-0033-1357363.


Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells.

de Vries SA, Potier E, van Doeselaar M, Meij BP, Tryfonidou MA, Ito K.

Tissue Eng Part A. 2015 Mar;21(5-6):1077-84. doi: 10.1089/ten.TEA.2014.0309. Epub 2014 Dec 17.


Environmental regulation of notochordal gene expression in nucleus pulposus cells.

Rastogi A, Thakore P, Leung A, Benavides M, Machado M, Morschauser MA, Hsieh AH.

J Cell Physiol. 2009 Sep;220(3):698-705. doi: 10.1002/jcp.21816.


Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (hMSC).

Ehlicke F, Freimark D, Heil B, Dorresteijn A, Czermak P.

Int J Artif Organs. 2010 Apr;33(4):244-52.


Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development.

Purmessur D, Guterl CC, Cho SK, Cornejo MC, Lam YW, Ballif BA, Laudier JC, Iatridis JC.

Arthritis Res Ther. 2013;15(5):R122.


Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration.

Smolders LA, Meij BP, Riemers FM, Licht R, Wubbolts R, Heuvel D, Grinwis GC, Vernooij HC, Hazewinkel HA, Penning LC, Tryfonidou MA.

J Orthop Res. 2012 Jun;30(6):950-7. doi: 10.1002/jor.22000. Epub 2011 Nov 14.


Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells.

Abbott RD, Purmessur D, Monsey RD, Iatridis JC.

J Orthop Res. 2012 Mar;30(3):482-8. doi: 10.1002/jor.21534. Epub 2011 Aug 22.


Molecular phenotypes of notochordal cells purified from immature nucleus pulposus.

Chen J, Yan W, Setton LA.

Eur Spine J. 2006 Aug;15 Suppl 3:S303-11. Epub 2006 Mar 18.


Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model.

Jeon K, Lim H, Kim JH, Thuan NV, Park SH, Lim YM, Choi HY, Lee ER, Kim JH, Lee MS, Cho SG.

Stem Cells Dev. 2012 Sep 20;21(14):2642-55. doi: 10.1089/scd.2011.0665. Epub 2012 Jun 1.


An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

Le Maitre CL, Baird P, Freemont AJ, Hoyland JA.

Arthritis Res Ther. 2009;11(1):R20. doi: 10.1186/ar2611. Epub 2009 Feb 11.


Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells.

Li HY, Chien Y, Chen YJ, Chen SF, Chang YL, Chiang CH, Jeng SY, Chang CM, Wang ML, Chen LK, Hung SI, Huo TI, Lee SD, Chiou SH.

Biomaterials. 2011 Sep;32(26):5994-6005. doi: 10.1016/j.biomaterials.2011.05.009. Epub 2011 Jun 11.

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