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Results: 1 to 20 of 103

1.

Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK.

Nomura J, Busso N, Ives A, Tsujimoto S, Tamura M, So A, Yamanaka Y.

PLoS One. 2013 Sep 25;8(9):e75527. doi: 10.1371/journal.pone.0075527. eCollection 2013.

PMID:
24086554
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Xanthine oxidase inhibitor febuxostat as a novel agent postulated to act against vascular inflammation.

Sabán-Ruiz J, Alonso-Pacho A, Fabregate-Fuente M, de la Puerta González-Quevedo C.

Antiinflamm Antiallergy Agents Med Chem. 2013;12(1):94-9. Review.

PMID:
23286293
[PubMed - indexed for MEDLINE]
3.

Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.

Honorat JA, Kinoshita M, Okuno T, Takata K, Koda T, Tada S, Shirakura T, Fujimura H, Mochizuki H, Sakoda S, Nakatsuji Y.

PLoS One. 2013 Aug 8;8(8):e71329. doi: 10.1371/journal.pone.0071329. eCollection 2013.

PMID:
23951137
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production.

Malik UZ, Hundley NJ, Romero G, Radi R, Freeman BA, Tarpey MM, Kelley EE.

Free Radic Biol Med. 2011 Jul 1;51(1):179-84. doi: 10.1016/j.freeradbiomed.2011.04.004. Epub 2011 Apr 15.

PMID:
21554948
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts.

Liu RM, Choi J, Wu JH, Gaston Pravia KA, Lewis KM, Brand JD, Mochel NS, Krzywanski DM, Lambeth JD, Hagood JS, Forman HJ, Thannickal VJ, Postlethwait EM.

J Biol Chem. 2010 May 21;285(21):16239-47. doi: 10.1074/jbc.M110.111732. Epub 2010 Mar 12.

PMID:
20228065
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Suppressing LPS-induced early signal transduction in macrophages by a polyphenol degradation product: a critical role of MKP-1.

Tucsek Z, Radnai B, Racz B, Debreceni B, Priber JK, Dolowschiak T, Palkovics T, Gallyas F Jr, Sumegi B, Veres B.

J Leukoc Biol. 2011 Jan;89(1):105-11. doi: 10.1189/jlb.0610355. Epub 2010 Sep 30.

PMID:
20884647
[PubMed - indexed for MEDLINE]
Free Article
8.

Propofol attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production through p38 MAPK and SAPK/JNK in alveolar epithelial cells.

Wei L, Matsumoto H, Yamaguchi H.

J Anesth. 2013 Jun;27(3):366-73. doi: 10.1007/s00540-012-1539-7. Epub 2012 Dec 21.

PMID:
23262985
[PubMed - indexed for MEDLINE]
9.

Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1.

Ichikawa T, Zhang J, Chen K, Liu Y, Schopfer FJ, Baker PR, Freeman BA, Chen YE, Cui T.

Endocrinology. 2008 Aug;149(8):4086-94. doi: 10.1210/en.2007-1639. Epub 2008 May 8.

PMID:
18467446
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells.

Chen TH, Kao YC, Chen BC, Chen CH, Chan P, Lee HM.

Eur J Pharmacol. 2006 Jul 17;541(3):138-46.

PMID:
16765938
[PubMed - indexed for MEDLINE]
11.

Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice.

Nomura J, Busso N, Ives A, Matsui C, Tsujimoto S, Shirakura T, Tamura M, Kobayashi T, So A, Yamanaka Y.

Sci Rep. 2014 Apr 1;4:4554. doi: 10.1038/srep04554.

PMID:
24686534
[PubMed - in process]
Free PMC Article
12.

Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling.

Lee JG, Lee SH, Park DW, Lee SH, Yoon HS, Chin BR, Kim JH, Kim JR, Baek SH.

Cell Signal. 2008 Jan;20(1):105-11. Epub 2007 Sep 22.

PMID:
17939949
[PubMed - indexed for MEDLINE]
13.

The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1 independent of estrogen receptor.

Lee SA, Kim EY, Jeon WK, Woo CH, Choe J, Han S, Kim BC.

Biochimie. 2011 Feb;93(2):168-74. doi: 10.1016/j.biochi.2010.09.007. Epub 2010 Oct 1.

PMID:
20888885
[PubMed - indexed for MEDLINE]
14.

The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.

Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y.

J Biol Chem. 2005 Mar 4;280(9):8101-8. Epub 2004 Dec 8.

PMID:
15590669
[PubMed - indexed for MEDLINE]
Free Article
15.

Heme oxygenase-1-mediated reactive oxygen species reduction is involved in the inhibitory effect of curcumin on lipopolysaccharide-induced monocyte chemoattractant protein-1 production in RAW264.7 macrophages.

Zhong Y, Liu T, Lai W, Tan Y, Tian D, Guo Z.

Mol Med Rep. 2013 Jan;7(1):242-6. doi: 10.3892/mmr.2012.1138. Epub 2012 Oct 22.

PMID:
23124098
[PubMed - indexed for MEDLINE]
16.

Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress.

Tsuda H, Kawada N, Kaimori JY, Kitamura H, Moriyama T, Rakugi H, Takahara S, Isaka Y.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):266-72. doi: 10.1016/j.bbrc.2012.09.032. Epub 2012 Sep 17.

PMID:
22995295
[PubMed - indexed for MEDLINE]
17.

Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury.

Cornell TT, Fleszar A, McHugh W, Blatt NB, Le Vine AM, Shanley TP.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L251-8. doi: 10.1152/ajplung.00063.2012. Epub 2012 Jun 8.

PMID:
22683570
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability.

Lee JH, Kim H, Woo JH, Joe EH, Jou I.

J Neuroinflammation. 2012 Feb 18;9:34. doi: 10.1186/1742-2094-9-34.

PMID:
22339770
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Nitric oxide inactivates xanthine dehydrogenase and xanthine oxidase in interferon-gamma-stimulated macrophages.

Rinaldo JE, Clark M, Parinello J, Shepherd VL.

Am J Respir Cell Mol Biol. 1994 Nov;11(5):625-30.

PMID:
7524568
[PubMed - indexed for MEDLINE]
20.

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