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Results: 1 to 20 of 142

1.

Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations.

Huan X, Shi J, Lim L, Mitra S, Zhu W, Qin H, Pasquale EB, Song J.

PLoS One. 2013 Sep 24;8(9):e74040. doi: 10.1371/journal.pone.0074040. eCollection 2013.

PMID:
24086308
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

Qin H, Shi J, Noberini R, Pasquale EB, Song J.

J Biol Chem. 2008 Oct 24;283(43):29473-84. doi: 10.1074/jbc.M804114200. Epub 2008 Aug 14.

PMID:
18708347
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.

Qin H, Lim L, Song J.

BMC Biophys. 2012 Jan 25;5:2. doi: 10.1186/2046-1682-5-2.

PMID:
22277260
[PubMed]
Free PMC Article
4.

Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

Qin H, Noberini R, Huan X, Shi J, Pasquale EB, Song J.

J Biol Chem. 2010 Jan 1;285(1):644-54. doi: 10.1074/jbc.M109.064824. Epub 2009 Oct 29.

PMID:
19875447
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Sizes of interface residues account for cross-class binding affinity patterns in Eph receptor-ephrin families.

Guo FY, Lesk AM.

Proteins. 2014 Mar;82(3):349-53. doi: 10.1002/prot.24414. Epub 2013 Oct 18.

PMID:
24105818
[PubMed - indexed for MEDLINE]
6.

Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.

Bowden TA, Aricescu AR, Nettleship JE, Siebold C, Rahman-Huq N, Owens RJ, Stuart DI, Jones EY.

Structure. 2009 Oct 14;17(10):1386-97. doi: 10.1016/j.str.2009.07.018.

PMID:
19836338
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution.

Goldgur Y, Paavilainen S, Nikolov D, Himanen JP.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):71-4. doi: 10.1107/S1744309108043078. Epub 2009 Jan 31.

PMID:
19193989
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.

Himanen JP, Henkemeyer M, Nikolov DB.

Nature. 1998 Dec 3;396(6710):486-91.

PMID:
9853759
[PubMed - indexed for MEDLINE]
9.

NMR structure and dynamics of human ephrin-B2 ectodomain: the functionally critical C-D and G-H loops are highly dynamic in solution.

Ran X, Qin H, Liu J, Fan JS, Shi J, Song J.

Proteins. 2008 Aug 15;72(3):1019-29. doi: 10.1002/prot.21999.

PMID:
18300229
[PubMed - indexed for MEDLINE]
10.

Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.

Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14634-9. doi: 10.1073/pnas.1311000110. Epub 2013 Aug 19.

PMID:
23959867
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.

Noberini R, Koolpe M, Peddibhotla S, Dahl R, Su Y, Cosford ND, Roth GP, Pasquale EB.

J Biol Chem. 2008 Oct 24;283(43):29461-72. doi: 10.1074/jbc.M804103200. Epub 2008 Aug 26.

PMID:
18728010
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.

Koolpe M, Burgess R, Dail M, Pasquale EB.

J Biol Chem. 2005 Apr 29;280(17):17301-11. Epub 2005 Feb 18.

PMID:
15722342
[PubMed - indexed for MEDLINE]
Free Article
13.

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.

Lamberto I, Qin H, Noberini R, Premkumar L, Bourgin C, Riedl SJ, Song J, Pasquale EB.

Biochem J. 2012 Jul 1;445(1):47-56. doi: 10.1042/BJ20120408.

PMID:
22489865
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Crystal structure of an Eph receptor-ephrin complex.

Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB.

Nature. 2001 Dec 20-27;414(6866):933-8.

PMID:
11780069
[PubMed - indexed for MEDLINE]
15.

Conformational and dynamics changes induced by bile acids binding to chicken liver bile acid binding protein.

Eberini I, Guerini Rocco A, Ientile AR, Baptista AM, Gianazza E, Tomaselli S, Molinari H, Ragona L.

Proteins. 2008 Jun;71(4):1889-98. doi: 10.1002/prot.21875.

PMID:
18175325
[PubMed - indexed for MEDLINE]
16.

Crystal structure of the human ephrin-A5 ectodomain.

Nikolov D, Li C, Lackmann M, Jeffrey P, Himanen J.

Protein Sci. 2007 May;16(5):996-1000. Epub 2007 Mar 30.

PMID:
17400922
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.

Akaneya Y, Sohya K, Kitamura A, Kimura F, Washburn C, Zhou R, Ninan I, Tsumoto T, Ziff EB.

PLoS One. 2010 Aug 31;5(8):e12486. doi: 10.1371/journal.pone.0012486.

PMID:
20824214
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Eph receptors and ephrins: regulators of guidance and assembly.

Wilkinson DG.

Int Rev Cytol. 2000;196:177-244. Review.

PMID:
10730216
[PubMed - indexed for MEDLINE]
19.

Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.

Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA.

Mol Endocrinol. 2009 Jan;23(1):25-34. doi: 10.1210/me.2007-0508. Epub 2008 Nov 6.

PMID:
18988706
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB.

EMBO Rep. 2009 Jul;10(7):722-8. doi: 10.1038/embor.2009.91. Epub 2009 Jun 12.

PMID:
19525919
[PubMed - indexed for MEDLINE]
Free PMC Article

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