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Items: 1 to 20 of 149

1.

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

Kelsall IR, Duda DM, Olszewski JL, Hofmann K, Knebel A, Langevin F, Wood N, Wightman M, Schulman BA, Alpi AF.

EMBO J. 2013 Oct 30;32(21):2848-60. doi: 10.1038/emboj.2013.209. Epub 2013 Sep 27.

2.

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

Wenzel DM, Lissounov A, Brzovic PS, Klevit RE.

Nature. 2011 Jun 2;474(7349):105-8. doi: 10.1038/nature09966. Epub 2011 May 1.

3.

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.

Lechtenberg BC, Rajput A, Sanishvili R, Dobaczewska MK, Ware CF, Mace PD, Riedl SJ.

Nature. 2016 Jan 28;529(7587):546-50. doi: 10.1038/nature16511. Epub 2016 Jan 20.

4.

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.

Duda DM, Olszewski JL, Schuermann JP, Kurinov I, Miller DJ, Nourse A, Alpi AF, Schulman BA.

Structure. 2013 Jun 4;21(6):1030-41. doi: 10.1016/j.str.2013.04.019. Epub 2013 May 23.

5.

Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

Spratt DE, Mercier P, Shaw GS.

PLoS One. 2013 Aug 15;8(8):e74047. doi: 10.1371/journal.pone.0074047. eCollection 2013.

6.

The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.

Marteijn JA, van der Meer LT, Smit JJ, Noordermeer SM, Wissink W, Jansen P, Swarts HG, Hibbert RG, de Witte T, Sixma TK, Jansen JH, van der Reijden BA.

Leukemia. 2009 Aug;23(8):1480-9. doi: 10.1038/leu.2009.57. Epub 2009 Apr 2.

PMID:
19340006
7.

Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.

Soucy TA, Smith PG, Rolfe M.

Clin Cancer Res. 2009 Jun 15;15(12):3912-6. doi: 10.1158/1078-0432.CCR-09-0343. Epub 2009 Jun 9.

8.

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.

Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA.

J Biol Chem. 1999 Oct 22;274(43):30963-8.

9.

Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells.

Luo Z, Pan Y, Jeong LS, Liu J, Jia L.

Autophagy. 2012 Nov;8(11):1677-9. doi: 10.4161/auto.21484. Epub 2012 Aug 9.

10.

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.

Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA.

J Biol Chem. 2001 Jun 1;276(22):19640-7. Epub 2001 Mar 13.

11.

Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity.

Choo YY, Boh BK, Lou JJ, Eng J, Leck YC, Anders B, Smith PG, Hagen T.

Mol Biol Cell. 2011 Dec;22(24):4706-15. doi: 10.1091/mbc.E11-03-0251. Epub 2011 Oct 19.

12.

Control of cullin-ring ubiquitin ligase activity by nedd8.

Deshaies RJ, Emberley ED, Saha A.

Subcell Biochem. 2010;54:41-56. doi: 10.1007/978-1-4419-6676-6_4. Review.

PMID:
21222272
13.

Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases.

Tan CY, Hagen T.

Int J Biochem Cell Biol. 2013 Jul;45(7):1489-98. doi: 10.1016/j.biocel.2013.04.010. Epub 2013 Apr 15.

PMID:
23597704
14.

Structural regulation of cullin-RING ubiquitin ligase complexes.

Duda DM, Scott DC, Calabrese MF, Zimmerman ES, Zheng N, Schulman BA.

Curr Opin Struct Biol. 2011 Apr;21(2):257-64. doi: 10.1016/j.sbi.2011.01.003. Epub 2011 Feb 1. Review.

15.

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.

Dove KK, Stieglitz B, Duncan ED, Rittinger K, Klevit RE.

EMBO Rep. 2016 Aug;17(8):1221-35. doi: 10.15252/embr.201642641. Epub 2016 Jun 16.

PMID:
27312108
16.

Protection of cullin-RING E3 ligases by CSN-UBP12.

Wu JT, Chan YR, Chien CT.

Trends Cell Biol. 2006 Jul;16(7):362-9. Epub 2006 Jun 9. Review.

PMID:
16762551
17.

The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.

Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T, Löwenberg B, Jansen JH, van der Reijden BA.

Blood. 2005 Dec 15;106(13):4114-23. Epub 2005 Aug 23.

18.

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

den Besten W, Verma R, Kleiger G, Oania RS, Deshaies RJ.

Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1. doi: 10.1038/nsmb.2269.

19.

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.

Bandau S, Knebel A, Gage ZO, Wood NT, Alexandru G.

BMC Biol. 2012 Apr 26;10:36. doi: 10.1186/1741-7007-10-36.

20.

Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.

Megumi Y, Miyauchi Y, Sakurai H, Nobeyama H, Lorick K, Nakamura E, Chiba T, Tanaka K, Weissman AM, Kirisako T, Ogawa O, Iwai K.

Genes Cells. 2005 Jul;10(7):679-91.

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