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Results: 1 to 20 of 107

1.

SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice.

Li L, Wang C, Calvisi DF, Evert M, Pilo MG, Jiang L, Yuneva M, Chen X.

PLoS One. 2013 Sep 19;8(9):e75104. doi: 10.1371/journal.pone.0075104. eCollection 2013.

PMID:
24069385
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.

Benhamed F, Denechaud PD, Lemoine M, Robichon C, Moldes M, Bertrand-Michel J, Ratziu V, Serfaty L, Housset C, Capeau J, Girard J, Guillou H, Postic C.

J Clin Invest. 2012 Jun 1;122(6):2176-94. doi: 10.1172/JCI41636. Epub 2012 May 1.

PMID:
22546860
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M.

Gastroenterology. 2011 Mar;140(3):1071-83. doi: 10.1053/j.gastro.2010.12.006. Epub 2010 Dec 11.

PMID:
21147110
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.

Wang C, Delogu S, Ho C, Lee SA, Gui B, Jiang L, Ladu S, Cigliano A, Dombrowski F, Evert M, Calvisi DF, Chen X.

J Hepatol. 2012 Sep;57(3):577-83. doi: 10.1016/j.jhep.2012.04.026. Epub 2012 May 19.

PMID:
22617155
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis.

Scaglia N, Igal RA.

Int J Oncol. 2008 Oct;33(4):839-50.

PMID:
18813799
[PubMed - indexed for MEDLINE]
6.

Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.

Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avancès C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L.

Mol Cancer Ther. 2010 Jun;9(6):1740-54. doi: 10.1158/1535-7163.MCT-09-1064. Epub 2010 Jun 8.

PMID:
20530718
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis.

Evert M, Calvisi DF, Evert K, De Murtas V, Gasparetti G, Mattu S, Destefanis G, Ladu S, Zimmermann A, Delogu S, Thiel S, Thiele A, Ribback S, Dombrowski F.

Hepatology. 2012 May;55(5):1473-84. doi: 10.1002/hep.25600. Epub 2012 Apr 4.

PMID:
22271091
[PubMed - indexed for MEDLINE]
8.

Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.

Li ZZ, Berk M, McIntyre TM, Feldstein AE.

J Biol Chem. 2009 Feb 27;284(9):5637-44. doi: 10.1074/jbc.M807616200. Epub 2009 Jan 1.

PMID:
19119140
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.

Angrish MM, Jones AD, Harkema JR, Zacharewski TR.

Toxicol Sci. 2011 Dec;124(2):299-310. doi: 10.1093/toxsci/kfr226. Epub 2011 Sep 2.

PMID:
21890736
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.

Ho C, Wang C, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X, Calvisi DF.

Hepatology. 2012 Mar;55(3):833-45. doi: 10.1002/hep.24736. Epub 2011 Dec 19.

PMID:
21993994
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: implications for the treatment of human liver cancer.

Wang C, Cigliano A, Delogu S, Armbruster J, Dombrowski F, Evert M, Chen X, Calvisi DF.

Cell Cycle. 2013 Jul 1;12(13):1999-2010. doi: 10.4161/cc.25099. Epub 2013 Jun 6.

PMID:
23759595
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

Gutiérrez-Juárez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, Rossetti L.

J Clin Invest. 2006 Jun;116(6):1686-95.

PMID:
16741579
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios.

Peter A, Cegan A, Wagner S, Lehmann R, Stefan N, Königsrainer A, Königsrainer I, Häring HU, Schleicher E.

Clin Chem. 2009 Dec;55(12):2113-20. doi: 10.1373/clinchem.2009.127274. Epub 2009 Oct 22.

PMID:
19850634
[PubMed - indexed for MEDLINE]
Free Article
14.

Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors.

Stauffer JK, Scarzello AJ, Andersen JB, De Kluyver RL, Back TC, Weiss JM, Thorgeirsson SS, Wiltrout RH.

Cancer Res. 2011 Apr 1;71(7):2718-27. doi: 10.1158/0008-5472.CAN-10-2705. Epub 2011 Feb 15.

PMID:
21324921
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.

Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8882-7. doi: 10.1073/pnas.1307237110. Epub 2013 May 13.

PMID:
23671091
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T, Zhang BB.

J Clin Invest. 2005 Apr;115(4):1030-8. Epub 2005 Mar 10. Erratum in: J Clin Invest. 2005 Aug;115(8):2297.

PMID:
15761499
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth.

Du X, Wang QR, Chan E, Merchant M, Liu J, French D, Ashkenazi A, Qing J.

Cancer Res. 2012 Nov 15;72(22):5843-55. doi: 10.1158/0008-5472.CAN-12-1329. Epub 2012 Sep 26.

PMID:
23019225
[PubMed - indexed for MEDLINE]
Free Article
18.

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.

Anthérieu S, Rogue A, Fromenty B, Guillouzo A, Robin MA.

Hepatology. 2011 Jun;53(6):1895-905. doi: 10.1002/hep.24290. Epub 2011 May 2.

PMID:
21391224
[PubMed - indexed for MEDLINE]
19.

Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.

Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, Ntambi JM.

Cell Metab. 2007 Dec;6(6):484-96.

PMID:
18054317
[PubMed - indexed for MEDLINE]
Free Article
20.

Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma.

Muir K, Hazim A, He Y, Peyressatre M, Kim DY, Song X, Beretta L.

Cancer Res. 2013 Aug 1;73(15):4722-31. doi: 10.1158/0008-5472.CAN-12-3797. Epub 2013 Jun 7.

PMID:
23749645
[PubMed - indexed for MEDLINE]

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