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Double deficiency for RORγt and T-bet drives Th2-mediated allograft rejection in mice.

Sabet-Baktach M, Eggenhofer E, Rovira J, Renner P, Lantow M, Farkas SA, Malaisé M, Edtinger K, Shaotang Z, Koehl GE, Dahlke MH, Schlitt HJ, Geissler EK, Kroemer A.

J Immunol. 2013 Oct 15;191(8):4440-6. doi: 10.4049/jimmunol.1301741. Epub 2013 Sep 20.


The dynamic changes of T-bet(+)/GATA-3(+) and RORgammat(+)/FOXP3(+) cells in recipient spleens and grafts after rat orthotopic liver transplantation.

Xu M, Tan C, Zhou J, Huang X, Dai Z, Zhu H, Zhao Y, Gu F, Zhou S, Fan J.

Transpl Immunol. 2010 Feb;22(3-4):165-71. doi: 10.1016/j.trim.2009.11.003. Epub 2009 Nov 14.


Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response.

Simeonovic CJ, Townsend MJ, Karupiah G, Wilson JD, Zarb JC, Mann DA, Young IG.

Cell Transplant. 1999 Jul-Aug;8(4):365-73.


CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice.

Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK.

J Immunol. 2008 Sep 15;181(6):3906-14.


A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.

Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH, Ansari MJ.

J Exp Med. 2008 Dec 22;205(13):3133-44. doi: 10.1084/jem.20081937. Epub 2008 Dec 1.


Preliminary findings in corneal allograft rejection in patients with keratoconus.

Hargrave S, Chu Y, Mendelblatt D, Mayhew E, Niederkorn J.

Am J Ophthalmol. 2003 Apr;135(4):452-60.


[Regulation of Thl/Th2 cells by T cell-mediated transcription factor in rats with chronic obstructive pulmonary disease].

Wang CY, Liu XG, Wang CB, Ji QR, Fang L, Li Ze geng Z.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Nov;45(6):941-5. Chinese.


A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells.

Klose CS, Kiss EA, Schwierzeck V, Ebert K, Hoyler T, d'Hargues Y, Göppert N, Croxford AL, Waisman A, Tanriver Y, Diefenbach A.

Nature. 2013 Feb 14;494(7436):261-5. doi: 10.1038/nature11813. Epub 2013 Jan 16.


Shenghua Decoction reduces uterine bleeding and regulates T-cell paradigm in human deciduas of RU486 medical abortion.

Li X, Zhang M, Wang B, Li Y, Wang L, Zhao X, Zhou X, Guo Y, Jiang G, Yao C.

J Ethnopharmacol. 2013 Dec 12;150(3):907-17. doi: 10.1016/j.jep.2013.09.033. Epub 2013 Oct 17.


Carbon monoxide-releasing molecule-A1 inhibits Th1/Th17 and stimulates Th2 differentiation in vitro.

Nikolic I, Vujicic M, Stojanovic I, Stosic-Grujicic S, Saksida T.

Scand J Immunol. 2014 Aug;80(2):95-100. doi: 10.1111/sji.12189.


CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients.

Lendermon EA, Dodd-o JM, Coon TA, Miller HL, Ganguly S, Popescu I, O'Donnell CP, Cardenes N, Levine M, Rojas M, Weathington NM, Zhao J, Zhao Y, McDyer JF.

Am J Respir Cell Mol Biol. 2015 May;52(5):622-33. doi: 10.1165/rcmb.2014-0059OC.


CD27low natural killer cells prolong allograft survival in mice by controlling alloreactive CD8+ T cells in a T-bet-dependent manner.

Lantow M, Eggenhofer E, Sabet-Baktach M, Renner P, Rovira J, Koehl GE, Schlitt HJ, Geissler EK, Kroemer A.

Transplantation. 2015 Feb;99(2):391-9. doi: 10.1097/TP.0000000000000585.


The expression levels of transcription factors T-bet, GATA-3, RORγt and FOXP3 in peripheral blood lymphocyte (PBL) of patients with liver cancer and their significance.

Lin ZW, Wu LX, Xie Y, Ou X, Tian PK, Liu XP, Min J, Wang J, Chen RF, Chen YJ, Liu C, Ye H, Ou QJ.

Int J Med Sci. 2015 Jan 1;12(1):7-16. doi: 10.7150/ijms.8352. eCollection 2015.


High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response.

Duan L, Wang CY, Chen J, Gong Q, Zhu P, Zheng F, Tan Z, Gong F, Fang M.

Lab Invest. 2011 Jan;91(1):43-53. doi: 10.1038/labinvest.2010.141. Epub 2010 Aug 16.


Toxoplasma gondii infection inhibits Th17-mediated spontaneous development of arthritis in interleukin-1 receptor antagonist-deficient mice.

Washino T, Moroda M, Iwakura Y, Aosai F.

Infect Immun. 2012 Apr;80(4):1437-44. doi: 10.1128/IAI.05680-11. Epub 2012 Jan 30.


In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection.

Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK.

Transplantation. 1995 Apr 27;59(8):1155-61.


T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.

Yang Y, Xu J, Niu Y, Bromberg JS, Ding Y.

J Immunol. 2008 Dec 15;181(12):8700-10.

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