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Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression.

Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K.

J Allergy Clin Immunol. 2014 Jan;133(1):139-46.e1-10. doi: 10.1016/j.jaci.2013.07.027. Epub 2013 Sep 20.


Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.

Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD.

J Allergy Clin Immunol. 2012 Apr;129(4):1031-9.e1. doi: 10.1016/j.jaci.2011.12.989. Epub 2012 Feb 8.


Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

Pellerin L, Henry J, Hsu CY, Balica S, Jean-Decoster C, Méchin MC, Hansmann B, Rodriguez E, Weindinger S, Schmitt AM, Serre G, Paul C, Simon M.

J Allergy Clin Immunol. 2013 Apr;131(4):1094-102. doi: 10.1016/j.jaci.2012.12.1566. Epub 2013 Feb 10.


Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents.

van Drongelen V, Alloul-Ramdhani M, Danso MO, Mieremet A, Mulder A, van Smeden J, Bouwstra JA, El Ghalbzouri A.

Exp Dermatol. 2013 Dec;22(12):807-12. doi: 10.1111/exd.12271.


Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris.

Winge MC, Hoppe T, Berne B, Vahlquist A, Nordenskjöld M, Bradley M, Törmä H.

PLoS One. 2011;6(12):e28254. doi: 10.1371/journal.pone.0028254. Epub 2011 Dec 2.


A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis.

Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M.

J Allergy Clin Immunol. 2013 Nov;132(5):1111-1120.e4. doi: 10.1016/j.jaci.2013.08.027. Epub 2013 Sep 20.


The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling.

Amano W, Nakajima S, Kunugi H, Numata Y, Kitoh A, Egawa G, Dainichi T, Honda T, Otsuka A, Kimoto Y, Yamamoto Y, Tanimoto A, Matsushita M, Miyachi Y, Kabashima K.

J Allergy Clin Immunol. 2015 Sep;136(3):667-677.e7. doi: 10.1016/j.jaci.2015.03.051. Epub 2015 Jun 24.


Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge.

Ming M, Zhao B, Shea CR, Shah P, Qiang L, White SR, Sims DM, He YY.

J Allergy Clin Immunol. 2015 Apr;135(4):936-45.e4. doi: 10.1016/j.jaci.2014.09.035. Epub 2014 Nov 7.


Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.

Kezic S, O'Regan GM, Yau N, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, McLean WH, Irvine AD.

Allergy. 2011 Jul;66(7):934-40. doi: 10.1111/j.1398-9995.2010.02540.x. Epub 2011 Jan 25.


Staphylococcus aureus inhibits terminal differentiation of normal human keratinocytes by stimulating interleukin-6 secretion.

Son ED, Kim HJ, Park T, Shin K, Bae IH, Lim KM, Cho EG, Lee TR.

J Dermatol Sci. 2014 Apr;74(1):64-71. doi: 10.1016/j.jdermsci.2013.12.004. Epub 2013 Dec 17.


Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies.

Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H, Kubota Y.

Am J Pathol. 2012 Sep;181(3):969-77. doi: 10.1016/j.ajpath.2012.06.005. Epub 2012 Jul 13.


Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis.

Mlitz V, Latreille J, Gardinier S, Jdid R, Drouault Y, Hufnagl P, Eckhart L, Guinot C, Tschachler E.

J Eur Acad Dermatol Venereol. 2012 Aug;26(8):983-90. doi: 10.1111/j.1468-3083.2011.04198.x. Epub 2011 Aug 4.


Filaggrin in atopic dermatitis: flaky tail mice as a novel model for developing drug targets in atopic dermatitis.

Moniaga CS, Kabashima K.

Inflamm Allergy Drug Targets. 2011 Dec;10(6):477-85. Review.


Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.

Winge MC, Bilcha KD, Liedén A, Shibeshi D, Sandilands A, Wahlgren CF, McLean WH, Nordenskjöld M, Bradley M.

Br J Dermatol. 2011 Nov;165(5):1074-80. doi: 10.1111/j.1365-2133.2011.10475.x. Epub 2011 Oct 17.


Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV.

Li M, Cheng R, Shi M, Liu J, Zhang G, Liu Q, Yu H, Yao Z.

Br J Dermatol. 2013 Jun;168(6):1335-8. doi: 10.1111/bjd.12206. Epub 2013 Apr 1.


Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes.

O'Regan GM, Kemperman PM, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Puppels GJ, McLean WH, Caspers PJ, Irvine AD.

J Allergy Clin Immunol. 2010 Sep;126(3):574-80.e1. doi: 10.1016/j.jaci.2010.04.038.


MAP17 is associated with the T-helper cell cytokine-induced down-regulation of filaggrin transcription in human keratinocytes.

Noh M, Yeo H, Ko J, Kim HK, Lee CH.

Exp Dermatol. 2010 Apr;19(4):355-62. doi: 10.1111/j.1600-0625.2009.00902.x. Epub 2009 Jul 8.


Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema.

Jungersted JM, Scheer H, Mempel M, Baurecht H, Cifuentes L, Høgh JK, Hellgren LI, Jemec GB, Agner T, Weidinger S.

Allergy. 2010 Jul;65(7):911-8. doi: 10.1111/j.1398-9995.2010.02326.x. Epub 2010 Feb 4.


Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death.

Brauweiler AM, Bin L, Kim BE, Oyoshi MK, Geha RS, Goleva E, Leung DY.

J Allergy Clin Immunol. 2013 Feb;131(2):421-7.e1-2. doi: 10.1016/j.jaci.2012.10.030. Epub 2012 Dec 11.


IL-31 regulates differentiation and filaggrin expression in human organotypic skin models.

Cornelissen C, Marquardt Y, Czaja K, Wenzel J, Frank J, Lüscher-Firzlaff J, Lüscher B, Baron JM.

J Allergy Clin Immunol. 2012 Feb;129(2):426-33, 433.e1-8. doi: 10.1016/j.jaci.2011.10.042. Epub 2011 Dec 15.

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