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Results: 1 to 20 of 104

1.

Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.

Garcia S, Dirat B, Tognacci T, Rochet N, Mouska X, Bonnafous S, Patouraux S, Tran A, Gual P, Le Marchand-Brustel Y, Gennero I, Gouze E.

Sci Transl Med. 2013 Sep 18;5(203):203ra124. doi: 10.1126/scitranslmed.3006247.

PMID:
24048522
[PubMed - indexed for MEDLINE]
2.

PTH has the potential to rescue disturbed bone growth in achondroplasia.

Ueda K, Yamanaka Y, Harada D, Yamagami E, Tanaka H, Seino Y.

Bone. 2007 Jul;41(1):13-8. Epub 2007 Mar 12.

PMID:
17466614
[PubMed - indexed for MEDLINE]
3.

Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia.

Xie Y, Su N, Jin M, Qi H, Yang J, Li C, Du X, Luo F, Chen B, Shen Y, Huang H, Xian CJ, Deng C, Chen L.

Hum Mol Genet. 2012 Sep 15;21(18):3941-55. doi: 10.1093/hmg/dds181. Epub 2012 May 24.

PMID:
22634226
[PubMed - indexed for MEDLINE]
Free Article
4.

Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia--genetic short limbed dwarfism.

Aviezer D, Golembo M, Yayon A.

Curr Drug Targets. 2003 Jul;4(5):353-65. Review.

PMID:
12816345
[PubMed - indexed for MEDLINE]
5.

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.

Murakami S, Balmes G, McKinney S, Zhang Z, Givol D, de Crombrugghe B.

Genes Dev. 2004 Feb 1;18(3):290-305.

PMID:
14871928
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Delayed bone age due to a dual effect of FGFR3 mutation in Achondroplasia.

Pannier S, Mugniery E, Jonquoy A, Benoist-Lasselin C, Odent T, Jais JP, Munnich A, Legeai-Mallet L.

Bone. 2010 Nov;47(5):905-15. doi: 10.1016/j.bone.2010.07.020. Epub 2010 Jul 29.

PMID:
20673820
[PubMed - indexed for MEDLINE]
7.

Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia.

Lorget F, Kaci N, Peng J, Benoist-Lasselin C, Mugniery E, Oppeneer T, Wendt DJ, Bell SM, Bullens S, Bunting S, Tsuruda LS, O'Neill CA, Di Rocco F, Munnich A, Legeai-Mallet L.

Am J Hum Genet. 2012 Dec 7;91(6):1108-14. doi: 10.1016/j.ajhg.2012.10.014. Epub 2012 Nov 29.

PMID:
23200862
[PubMed - indexed for MEDLINE]
Free PMC Article
8.
9.

Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3.

Naski MC, Colvin JS, Coffin JD, Ornitz DM.

Development. 1998 Dec;125(24):4977-88.

PMID:
9811582
[PubMed - indexed for MEDLINE]
Free Article
10.

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.

Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX.

Hum Mol Genet. 1999 Jan;8(1):35-44.

PMID:
9887329
[PubMed - indexed for MEDLINE]
Free Article
11.

PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.

Yamanaka Y, Tanaka H, Koike M, Nishimura R, Seino Y.

J Bone Miner Res. 2003 Aug;18(8):1395-403.

PMID:
12929929
[PubMed - indexed for MEDLINE]
12.

A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model.

Jonquoy A, Mugniery E, Benoist-Lasselin C, Kaci N, Le Corre L, Barbault F, Girard AL, Le Merrer Y, Busca P, Schibler L, Munnich A, Legeai-Mallet L.

Hum Mol Genet. 2012 Feb 15;21(4):841-51. doi: 10.1093/hmg/ddr514. Epub 2011 Nov 9.

PMID:
22072392
[PubMed - indexed for MEDLINE]
Free Article
13.

Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains.

Wang Q, Green RP, Zhao G, Ornitz DM.

Development. 2001 Oct;128(19):3867-76.

PMID:
11585811
[PubMed - indexed for MEDLINE]
Free Article
14.

Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK.

Koike M, Yamanaka Y, Inoue M, Tanaka H, Nishimura R, Seino Y.

J Bone Miner Res. 2003 Nov;18(11):2043-51.

PMID:
14606518
[PubMed - indexed for MEDLINE]
15.

A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia.

Chen L, Li C, Qiao W, Xu X, Deng C.

Hum Mol Genet. 2001 Mar 1;10(5):457-65.

PMID:
11181569
[PubMed - indexed for MEDLINE]
Free Article
16.

Chimeras of the native form or achondroplasia mutant (G375C) of human fibroblast growth factor receptor 3 induce ligand-dependent differentiation of PC12 cells.

Thompson LM, Raffioni S, Wasmuth JJ, Bradshaw RA.

Mol Cell Biol. 1997 Jul;17(7):4169-77.

PMID:
9199352
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway.

Matsushita T, Wilcox WR, Chan YY, Kawanami A, Bükülmez H, Balmes G, Krejci P, Mekikian PB, Otani K, Yamaura I, Warman ML, Givol D, Murakami S.

Hum Mol Genet. 2009 Jan 15;18(2):227-40. doi: 10.1093/hmg/ddn339. Epub 2008 Oct 15.

PMID:
18923003
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

[Cytokines in bone diseases. FGF receptor signaling and achondroplasia/hypochondroplasia].

Tanaka H.

Clin Calcium. 2010 Oct;20(10):1490-6. doi: CliCa101014901496. Review. Japanese.

PMID:
20890030
[PubMed - indexed for MEDLINE]
19.

FGFR3 targeting strategies for achondroplasia.

Laederich MB, Horton WA.

Expert Rev Mol Med. 2012 Jan 19;14:e11. doi: 10.1017/erm.2012.4. Review.

PMID:
22559284
[PubMed - indexed for MEDLINE]
20.

A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3.

Wang Y, Spatz MK, Kannan K, Hayk H, Avivi A, Gorivodsky M, Pines M, Yayon A, Lonai P, Givol D.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4455-60.

PMID:
10200283
[PubMed - indexed for MEDLINE]
Free PMC Article

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