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Items: 1 to 20 of 104


Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization.

Wang H, Jiang Y, Shi D, Quilliam LA, Chrzanowska-Wodnicka M, Wittchen ES, Li DY, Hartnett ME.

FASEB J. 2014 Jan;28(1):265-74. doi: 10.1096/fj.13-240028. Epub 2013 Sep 16.


Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.

Wittchen ES, Nishimura E, McCloskey M, Wang H, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME.

PLoS One. 2013 Sep 10;8(9):e73070. doi: 10.1371/journal.pone.0073070. eCollection 2013.


Rap1 GTPase Inhibits Tumor Necrosis Factor-α-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-κB-Dependent Activation of Rac1.

Wang H, Fotheringham L, Wittchen ES, Hartnett ME.

Am J Pathol. 2015 Dec;185(12):3316-25. doi: 10.1016/j.ajpath.2015.08.017. Epub 2015 Oct 23.


The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization.

Monaghan-Benson E, Hartmann J, Vendrov AE, Budd S, Byfield G, Parker A, Ahmad F, Huang W, Runge M, Burridge K, Madamanchi N, Hartnett ME.

Am J Pathol. 2010 Oct;177(4):2091-102. doi: 10.2353/ajpath.2010.090878. Epub 2010 Aug 27.


Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice.

Li Q, Dinculescu A, Shan Z, Miller R, Pang J, Lewin AS, Raizada MK, Hauswirth WW.

Mol Ther. 2008 Oct;16(10):1688-94. doi: 10.1038/mt.2008.164. Epub 2008 Jul 29.


Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.

Li Y, Liu X, Zhou T, Kelley MR, Edwards P, Gao H, Qiao X.

Redox Biol. 2014 Feb 21;2:485-94. doi: 10.1016/j.redox.2014.01.023. eCollection 2014.


Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells.

Li X, Cai Y, Wang YS, Shi YY, Hou W, Xu CS, Wang HY, Ye Z, Yao LB, Zhang J.

PLoS One. 2012;7(10):e47600. doi: 10.1371/journal.pone.0047600. Epub 2012 Oct 19.


The small GTPase Rap1 is a novel regulator of RPE cell barrier function.

Wittchen ES, Hartnett ME.

Invest Ophthalmol Vis Sci. 2011 Sep 27;52(10):7455-63. doi: 10.1167/iovs.11-7295.


Targeting of junctional adhesion molecule-C inhibits experimental choroidal neovascularization.

Hou X, Hu D, Wang YS, Tang ZS, Zhang F, Chavakis T, Li Y, Li X.

Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1584-91. doi: 10.1167/iovs.11-9005. Print 2012 Mar.


Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells.

Shi YY, Wang YS, Zhang ZX, Cai Y, Zhou J, Hou HY, van Rooijen N.

Graefes Arch Clin Exp Ophthalmol. 2011 Nov;249(11):1667-79. doi: 10.1007/s00417-011-1699-4. Epub 2011 Jun 8.


Localizing NADPH oxidase-derived ROS.

Ushio-Fukai M.

Sci STKE. 2006 Aug 22;2006(349):re8. Review.


The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE.

Wang H, Geisen P, Wittchen ES, King B, Burridge K, D'Amore PA, Hartnett ME.

Invest Ophthalmol Vis Sci. 2011 Feb 1;52(1):570-8. doi: 10.1167/iovs.10-5595. Print 2011 Jan.


Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.

Lin M, Hu Y, Chen Y, Zhou KK, Jin J, Zhu M, Le YZ, Ge J, Ma JX.

Invest Ophthalmol Vis Sci. 2012 Sep 14;53(10):6197-206. doi: 10.1167/iovs.11-8936.


Hypoxia specific SDF-1 expression by retinal pigment epithelium initiates bone marrow-derived cells to participate in Choroidal neovascularization in a laser-induced mouse model.

Zhang ZX, Wang YS, Shi YY, Hou HY, Zhang C, Cai Y, Dou GR, Yao LB, Li FY.

Curr Eye Res. 2011 Sep;36(9):838-49. doi: 10.3109/02713683.2011.593107.


Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization.

Yoshikawa N, Noda K, Ozawa Y, Tsubota K, Mashima Y, Ishida S.

Mol Vis. 2012;18:593-600. Epub 2012 Mar 2.


Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization.

Semkova I, Fauser S, Lappas A, Smyth N, Kociok N, Kirchhof B, Paulsson M, Poulaki V, Joussen AM.

FASEB J. 2006 Aug;20(10):1689-91. Epub 2006 Jun 28.

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