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COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis.

Shao J, Teng Y, Padia R, Hong S, Noh H, Xie X, Mumm JS, Dong Z, Ding HF, Cowell J, Kim J, Han J, Huang S.

Neoplasia. 2013 Sep;15(9):1075-85.


Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.

Migliorini D, Bogaerts S, Defever D, Vyas R, Denecker G, Radaelli E, Zwolinska A, Depaepe V, Hochepied T, Skarnes WC, Marine JC.

J Clin Invest. 2011 Apr;121(4):1329-43. doi: 10.1172/JCI45784. Epub 2011 Mar 14.


COP1D, an alternatively spliced constitutive photomorphogenic-1 (COP1) product, stabilizes UV stress-induced c-Jun through inhibition of full-length COP1.

Savio MG, Rotondo G, Maglie S, Rossetti G, Bender JR, Pardi R.

Oncogene. 2008 Apr 10;27(17):2401-11. Epub 2007 Oct 29.


14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.

Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH.

Cancer Res. 2011 Feb 1;71(3):884-94. doi: 10.1158/0008-5472.CAN-10-2518. Epub 2010 Dec 6.


Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells.

Sarkar TR, Sharan S, Wang J, Pawar SA, Cantwell CA, Johnson PF, Morrison DK, Wang JM, Sterneck E.

Mol Cell Biol. 2012 Jan;32(2):320-32. doi: 10.1128/MCB.05790-11. Epub 2011 Oct 28.


Loss of COP1 expression determines poor prognosisin patients with gastric cancer.

Sawada G, Ueo H, Matsumura T, Uchi R, Ishibashi M, Mima K, Kurashige J, Takahashi Y, Akiyoshi S, Sudo T, Sugimachi K, Doki Y, Mori M, Mimori K.

Oncol Rep. 2013 Oct;30(4):1971-5. doi: 10.3892/or.2013.2664. Epub 2013 Aug 8.


COP1 is a tumour suppressor that causes degradation of ETS transcription factors.

Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM.

Nature. 2011 May 15;474(7351):403-6. doi: 10.1038/nature10005.


Good COP1 or bad COP1? In vivo veritas.

Wei W, Kaelin WG Jr.

J Clin Invest. 2011 Apr;121(4):1263-5. doi: 10.1172/JCI57080. Epub 2011 Mar 14.


Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.

Choi HH, Guma S, Fang L, Phan L, Ivan C, Baggerly K, Sood A, Lee MH.

Cell Cycle. 2015;14(14):2265-73. doi: 10.1080/15384101.2015.1046655. Epub 2015 May 6.


DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.

Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, Yoshida K.

J Clin Invest. 2012 Mar;122(3):859-72. doi: 10.1172/JCI60818. Epub 2012 Feb 6.


Spotlight on the role of COP1 in tumorigenesis.

Marine JC.

Nat Rev Cancer. 2012 Jun 7;12(7):455-64. doi: 10.1038/nrc3271. Review.


WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.

Yeung B, Ho KC, Yang X.

PLoS One. 2013;8(4):e61027. doi: 10.1371/journal.pone.0061027. Epub 2013 Apr 3.


The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.

Zhao D, Zheng HQ, Zhou Z, Chen C.

Cancer Res. 2010 Jun 1;70(11):4728-38. doi: 10.1158/0008-5472.CAN-10-0040. Epub 2010 May 18.


Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.

Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB, Zeng MS.

Mol Cancer. 2011 Jan 28;10(1):10. doi: 10.1186/1476-4598-10-10.


GSK3-SCF(FBXW7) targets JunB for degradation in G2 to preserve chromatid cohesion before anaphase.

Pérez-Benavente B, García JL, Rodríguez MS, Pineda-Lucena A, Piechaczyk M, Font de Mora J, Farràs R.

Oncogene. 2013 Apr 25;32(17):2189-99. doi: 10.1038/onc.2012.235. Epub 2012 Jun 18.


Crk adaptor proteins act as key signaling integrators for breast tumorigenesis.

Fathers KE, Bell ES, Rajadurai CV, Cory S, Zhao H, Mourskaia A, Zuo D, Madore J, Monast A, Mes-Masson AM, Grosset AA, Gaboury L, Hallet M, Siegel P, Park M.

Breast Cancer Res. 2012 May 8;14(3):R74.


C-Terminus of Hsc70-interacting protein regulates profilin1 and breast cancer cell migration.

Choi YN, Lee SK, Seo TW, Lee JS, Yoo SJ.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1060-6. doi: 10.1016/j.bbrc.2014.03.061. Epub 2014 Mar 21.

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