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A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.

Burger AM, Gao Y, Amemiya Y, Kahn HJ, Kitching R, Yang Y, Sun P, Narod SA, Hanna WM, Seth AK.

Cancer Res. 2005 Nov 15;65(22):10401-12.


Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor.

Kona FR, Stark K, Bisoski L, Buac D, Cui Q, Dou QP.

Breast Cancer Res Treat. 2012 Sep;135(2):495-503. doi: 10.1007/s10549-012-2107-4. Epub 2012 Aug 1.


E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation.

Zhi X, Zhao D, Wang Z, Zhou Z, Wang C, Chen W, Liu R, Chen C.

Cancer Res. 2013 Jan 1;73(1):385-94. doi: 10.1158/0008-5472.CAN-12-0562. Epub 2012 Oct 1.


Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.

Amemiya Y, Azmi P, Seth A.

Mol Cancer Res. 2008 Sep;6(9):1385-96. doi: 10.1158/1541-7786.MCR-08-0094.


Regulation of metformin response by breast cancer associated gene 2.

Buac D, Kona FR, Seth AK, Dou QP.

Neoplasia. 2013 Dec;15(12):1379-90.


The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation.

Zhu J, Zhao C, Kharman-Biz A, Zhuang T, Jonsson P, Liang N, Williams C, Lin CY, Qiao Y, Zendehdel K, Strömblad S, Treuter E, Dahlman-Wright K.

Oncogene. 2014 Aug 21;33(34):4340-51. doi: 10.1038/onc.2013.573. Epub 2014 Jan 20.


Effects of partner proteins on BCA2 RING ligase activity.

Bacopulos S, Amemiya Y, Yang W, Zubovits J, Burger A, Yaffe M, Seth AK.

BMC Cancer. 2012 Feb 8;12:63. doi: 10.1186/1471-2407-12-63.


Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway.

Liao XH, Lu DL, Wang N, Liu LY, Wang Y, Li YQ, Yan TB, Sun XG, Hu P, Zhang TC.

FEBS J. 2014 Feb;281(3):927-42. doi: 10.1111/febs.12658. Epub 2014 Jan 2.


Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells.

Choi YH, Yoo YH.

Oncol Rep. 2012 Dec;28(6):2163-9. doi: 10.3892/or.2012.2060. Epub 2012 Sep 26.


IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells.

Zuo S, Liu C, Wang J, Wang F, Xu W, Cui S, Yuan L, Chen X, Fan W, Cui M, Song G.

J Cancer Res Clin Oncol. 2012 Jun;138(6):1045-55. doi: 10.1007/s00432-012-1153-y. Epub 2012 Mar 6.


Roles of estrogen receptor and p21(Waf1) in bortezomib-induced growth inhibition in human breast cancer cells.

Maynadier M, Shi J, Vaillant O, Gary-Bobo M, Basile I, Gleizes M, Cathiard AM, Wah JL, Sheikh MS, Garcia M.

Mol Cancer Res. 2012 Nov;10(11):1473-81. doi: 10.1158/1541-7786.MCR-12-0133. Epub 2012 Sep 10.


Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.

Brahemi G, Kona FR, Fiasella A, Buac D, Soukupová J, Brancale A, Burger AM, Westwell AD.

J Med Chem. 2010 Apr 8;53(7):2757-65. doi: 10.1021/jm901757t.


Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.

Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A.

Mol Cell Biol. 2011 Aug;31(15):3136-45. doi: 10.1128/MCB.05496-11. Epub 2011 May 31.


BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.

Yu X, Luo Y, Zhou Y, Zhang Q, Wang J, Wei N, Mi M, Zhu J, Wang B, Chang H, Tang Y.

Int J Oncol. 2008 Sep;33(3):555-63.


WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.

Li Y, Zhou Z, Alimandi M, Chen C.

Oncogene. 2009 Aug 20;28(33):2948-58. doi: 10.1038/onc.2009.162. Epub 2009 Jun 29.


WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.

Yeung B, Ho KC, Yang X.

PLoS One. 2013;8(4):e61027. doi: 10.1371/journal.pone.0061027. Epub 2013 Apr 3.


Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells.

Ang EZ, Nguyen HT, Sim HL, Putti TC, Lim LH.

Mol Cancer Res. 2009 Feb;7(2):266-74. doi: 10.1158/1541-7786.MCR-08-0147. Epub 2009 Feb 10.


Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate.

Zhang X, Min KW, Wimalasena J, Baek SJ.

J Cancer Res Clin Oncol. 2012 Dec;138(12):2051-60. doi: 10.1007/s00432-012-1276-1. Epub 2012 Jul 20.


FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.

Liu Y, Ao X, Jia Z, Bai XY, Xu Z, Hu G, Jiang X, Chen M, Wu H.

Sci Rep. 2015 Mar 5;5:8796. doi: 10.1038/srep08796.

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