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Results: 1 to 20 of 107

1.

The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.

Kumagai K, Saikawa Y, Takeuchi H, Suda K, Fukuda K, Nakamura R, Takahashi T, Kawakubo H, Wada N, Miyasho T, Kitagawa Y.

Anticancer Res. 2013 Sep;33(9):3653-9.

PMID:
24023292
[PubMed - indexed for MEDLINE]
2.

Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.

Suda K, Takeuchi H, Hagiwara T, Miyasho T, Okamoto M, Kawasako K, Yamada S, Suganuma K, Wada N, Saikawa Y, Fukunaga K, Funakoshi Y, Hashimoto S, Yokota H, Maruyama I, Ishizaka A, Kitagawa Y.

Shock. 2010 May;33(5):526-31. doi: 10.1097/SHK.0b013e3181cc064b.

PMID:
19953005
[PubMed - indexed for MEDLINE]
3.

Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.

Inoue Y, Seiyama A, Tanaka H, Ukai I, Akimau P, Nishino M, Shimazu T, Sugimoto H.

Crit Care Med. 2005 Aug;33(8):1814-22.

PMID:
16096460
[PubMed - indexed for MEDLINE]
4.

Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.

Sakashita A, Nishimura Y, Nishiuma T, Takenaka K, Kobayashi K, Kotani Y, Yokoyama M.

Eur J Pharmacol. 2007 Sep 24;571(1):62-71. Epub 2007 Jun 9.

PMID:
17599828
[PubMed - indexed for MEDLINE]
5.

Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.

Song JS, Kang CM, Rhee CK, Yoon HK, Kim YK, Moon HS, Park SH.

Exp Lung Res. 2009 Dec;35(10):817-29. doi: 10.3109/01902140902912527.

PMID:
19995276
[PubMed - indexed for MEDLINE]
6.

A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.

Hagiwara S, Iwasaka H, Togo K, Noguchi T.

Inflammation. 2008 Aug;31(4):227-34. doi: 10.1007/s10753-008-9069-z.

PMID:
18536984
[PubMed - indexed for MEDLINE]
7.

Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.

Wada Y, Yoshida K, Hihara J, Konishi K, Tanabe K, Ukon K, Taomoto J, Suzuki T, Mizuiri H.

Cancer Sci. 2006 Oct;97(10):1037-43. Epub 2006 Aug 17.

PMID:
16918998
[PubMed - indexed for MEDLINE]
8.

A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.

Takemasa A, Ishii Y, Fukuda T.

Eur Respir J. 2012 Dec;40(6):1475-82. doi: 10.1183/09031936.00127011. Epub 2012 Mar 22. Erratum in: Eur Respir J. 2014 Oct;44(4):1101.

PMID:
22441751
[PubMed - indexed for MEDLINE]
Free Article
9.

Effect of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass: a prospective randomized study.

Kohira S, Oka N, Inoue N, Itatani K, Hanayama N, Kitamura T, Fujii M, Takeda A, Oshima H, Tojo K, Yoshitake S, Miyaji K.

Artif Organs. 2013 Dec;37(12):1027-33. doi: 10.1111/aor.12103. Epub 2013 Jul 3.

PMID:
23834653
[PubMed - indexed for MEDLINE]
10.

Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation.

Matsuzaki K, Hiramatsu Y, Homma S, Sato S, Shigeta O, Sakakibara Y.

Ann Thorac Surg. 2005 Aug;80(2):611-7.

PMID:
16039215
[PubMed - indexed for MEDLINE]
11.

Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.

Nawa M, Osada S, Morimitsu K, Nonaka K, Futamura M, Kawaguchi Y, Yoshida K.

Anticancer Res. 2012 Jan;32(1):13-9.

PMID:
22213283
[PubMed - indexed for MEDLINE]
12.

Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.

Shimoda M, Iwasaki Y, Okada T, Sawada T, Kubota K.

Eur J Pharmacol. 2008 Jun 10;587(1-3):248-52. doi: 10.1016/j.ejphar.2008.02.064. Epub 2008 Feb 29.

PMID:
18374331
[PubMed - indexed for MEDLINE]
13.

Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats.

Souza YM, Fontes B, Martins JO, Sannomiya P, Brito GS, Younes RN, Rasslan S.

Clinics (Sao Paulo). 2010 Feb;65(2):195-202. doi: 10.1590/S1807-59322010000200012.

PMID:
20186304
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis.

Maier S, Traeger T, Entleutner M, Westerholt A, Kleist B, Hüser N, Holzmann B, Stier A, Pfeffer K, Heidecke CD.

Shock. 2004 Jun;21(6):505-11.

PMID:
15167678
[PubMed - indexed for MEDLINE]
15.

Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB.

Hagiwara S, Iwasaka H, Hidaka S, Hasegawa A, Noguchi T.

Inflamm Res. 2009 Apr;58(4):198-203. doi: 10.1007/s00011-008-8131-5.

PMID:
19169649
[PubMed - indexed for MEDLINE]
16.

Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.

Fujimura N, Obara H, Suda K, Takeuchi H, Miyasho T, Kawasako K, Du W, Yamada S, Ono S, Matsumoto K, Matsuda S, Yagi H, Kitago M, Shinoda M, Itano O, Tanabe M, Sakamoto M, Maruyama I, Kitagawa Y.

J Surg Res. 2013 Mar;180(1):e31-6. doi: 10.1016/j.jss.2012.04.037. Epub 2012 May 8.

PMID:
22595015
[PubMed - indexed for MEDLINE]
17.

Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.

Akamoto S, Okano K, Sano T, Yachida S, Izuishi K, Usuki H, Wakabayashi H, Suzuki Y.

Surg Today. 2007;37(5):359-65. Epub 2007 Apr 30.

PMID:
17468814
[PubMed - indexed for MEDLINE]
18.

Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.

Kawahara Y, Ninomiya I, Fujimura T, Funaki H, Nakagawara H, Takamura H, Oyama K, Tajima H, Fushida S, Inaba H, Kayahara M.

Dis Esophagus. 2010 May;23(4):329-39. doi: 10.1111/j.1442-2050.2009.01010.x. Epub 2009 Sep 25.

PMID:
19788440
[PubMed - indexed for MEDLINE]
19.

Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.

Yanagihara K, Fukuda Y, Seki M, Izumikawa K, Miyazaki Y, Hirakata Y, Tsukamoto K, Yamada Y, Kamhira S, Kohno S.

Exp Lung Res. 2007 Mar;33(2):71-80.

PMID:
17454103
[PubMed - indexed for MEDLINE]
20.

The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection.

Tsujii S, Okabayashi T, Shiga M, Takezaki Y, Sugimoto T, Kobayashi M, Hanazaki K.

World J Surg. 2012 May;36(5):1122-7. doi: 10.1007/s00268-012-1501-8.

PMID:
22366983
[PubMed - indexed for MEDLINE]

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