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Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.

Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ.

Nat Commun. 2013;4:2434. doi: 10.1038/ncomms3434. Erratum in: Nat Commun. 2013;4:2929. Ruzicky, Philip [corrected to Ruzycki, Philip].


Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5. doi: 10.1073/pnas.1119908109. Epub 2012 Feb 27.


Fructose consumption as a risk factor for non-alcoholic fatty liver disease.

Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalek MF.

J Hepatol. 2008 Jun;48(6):993-9. doi: 10.1016/j.jhep.2008.02.011. Epub 2008 Mar 10.


Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.

Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ.

J Am Soc Nephrol. 2014 Nov;25(11):2526-38. doi: 10.1681/ASN.2013080901. Epub 2014 May 29.


Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.

Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ.

PLoS One. 2012;7(10):e47948. doi: 10.1371/journal.pone.0047948. Epub 2012 Oct 24.


Obesity: fatty liver and the metabolic syndrome-fructose at fault?

Ray K.

Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):623. doi: 10.1038/nrgastro.2013.184. Epub 2013 Sep 17. No abstract available.


Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.

Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH.

J Biol Chem. 2014 Apr 18;289(16):10989-98. doi: 10.1074/jbc.M113.527002. Epub 2014 Feb 11.


Soft drinks consumption and nonalcoholic fatty liver disease.

Nseir W, Nassar F, Assy N.

World J Gastroenterol. 2010 Jun 7;16(21):2579-88.


Fructose as a key player in the development of fatty liver disease.

Basaranoglu M, Basaranoglu G, Sabuncu T, Sentürk H.

World J Gastroenterol. 2013 Feb 28;19(8):1166-72. doi: 10.3748/wjg.v19.i8.1166. Review.


Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet.

Wada T, Kenmochi H, Miyashita Y, Sasaki M, Ojima M, Sasahara M, Koya D, Tsuneki H, Sasaoka T.

Endocrinology. 2010 May;151(5):2040-9. doi: 10.1210/en.2009-0869. Epub 2010 Mar 8.


Fructose: metabolic, hedonic, and societal parallels with ethanol.

Lustig RH.

J Am Diet Assoc. 2010 Sep;110(9):1307-21. doi: 10.1016/j.jada.2010.06.008. Review.


Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment.

Vilà L, Rebollo A, Ađalsteisson GS, Alegret M, Merlos M, Roglans N, Laguna JC.

Toxicol Appl Pharmacol. 2011 Feb 15;251(1):32-40. doi: 10.1016/j.taap.2010.11.011. Epub 2010 Nov 29.


Fructose impairs glucose-induced hepatic triglyceride synthesis.

Huang D, Dhawan T, Young S, Yong WH, Boros LG, Heaney AP.

Lipids Health Dis. 2011 Jan 24;10:20. doi: 10.1186/1476-511X-10-20.


Long term metabolic syndrome induced by a high fat high fructose diet leads to minimal renal injury in C57BL/6 mice.

Dissard R, Klein J, Caubet C, Breuil B, Siwy J, Hoffman J, Sicard L, Ducassé L, Rascalou S, Payre B, Buléon M, Mullen W, Mischak H, Tack I, Bascands JL, Buffin-Meyer B, Schanstra JP.

PLoS One. 2013 Oct 3;8(10):e76703. doi: 10.1371/journal.pone.0076703. eCollection 2013.


Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome.

Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K.

Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E685-94. doi: 10.1152/ajpendo.00283.2010. Epub 2010 Sep 7. Review.


Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice.

DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH.

Mol Endocrinol. 2013 Nov;27(11):1887-96. doi: 10.1210/me.2013-1137. Epub 2013 Sep 12.


Metabolic syndrome: F stands for fructose and fat.

Lyssiotis CA, Cantley LC.

Nature. 2013 Oct 10;502(7470):181-2. doi: 10.1038/502181a. No abstract available.


Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice.

Spruss A, Kanuri G, Uebel K, Bischoff SC, Bergheim I.

Antioxid Redox Signal. 2011 Jun;14(11):2121-35. doi: 10.1089/ars.2010.3263. Epub 2011 Mar 16.


Way back for fructose and liver metabolism: bench side to molecular insights.

Rebollo A, Roglans N, Alegret M, Laguna JC.

World J Gastroenterol. 2012 Dec 7;18(45):6552-9. doi: 10.3748/wjg.v18.i45.6552. Review.


Effects of dietary fructose on liver steatosis in overfed mule ducks.

Davail S, Rideau N, Bernadet MD, André JM, Guy G, Hoo-Paris R.

Horm Metab Res. 2005 Jan;37(1):32-5.

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