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Results: 1 to 20 of 103

1.

General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.

She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG.

J Biol Chem. 2013 Oct 25;288(43):31250-60. doi: 10.1074/jbc.M113.498469. Epub 2013 Sep 9.

PMID:
24019515
[PubMed - indexed for MEDLINE]
2.

The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.

Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG.

Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1124-33. doi: 10.1152/ajpendo.00080.2013. Epub 2013 Sep 3.

PMID:
24002574
[PubMed - indexed for MEDLINE]
3.

Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.

Joshi MA, Jeoung NH, Obayashi M, Hattab EM, Brocken EG, Liechty EA, Kubek MJ, Vattem KM, Wek RC, Harris RA.

Biochem J. 2006 Nov 15;400(1):153-62.

PMID:
16875466
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy.

Lu Z, Xu X, Fassett J, Kwak D, Liu X, Hu X, Wang H, Guo H, Xu D, Yan S, McFalls EO, Lu F, Bache RJ, Chen Y.

Hypertension. 2014 Jan;63(1):128-35. doi: 10.1161/HYPERTENSIONAHA.113.02313. Epub 2013 Oct 28.

PMID:
24166753
[PubMed - indexed for MEDLINE]
5.

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC.

J Biol Chem. 2004 Aug 27;279(35):36553-61. Epub 2004 Jun 22.

PMID:
15213227
[PubMed - indexed for MEDLINE]
Free Article
6.

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.

Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC.

Genetics. 2000 Feb;154(2):787-801.

PMID:
10655230
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.

Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG.

J Nutr. 2010 Nov;140(11):2020-7. doi: 10.3945/jn.110.129197. Epub 2010 Sep 22.

PMID:
20861212
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat.

Chotechuang N, Azzout-Marniche D, Bos C, Chaumontet C, Gausserès N, Steiler T, Gaudichon C, Tomé D.

Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1313-23. doi: 10.1152/ajpendo.91000.2008. Epub 2009 Sep 8.

PMID:
19738034
[PubMed - indexed for MEDLINE]
Free Article
9.

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC.

Mol Cell Biol. 2004 Feb;24(3):1365-77.

PMID:
14729979
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.

Wu JY, Kao HJ, Li SC, Stevens R, Hillman S, Millington D, Chen YT.

J Clin Invest. 2004 Feb;113(3):434-40.

PMID:
14755340
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Dang Do AN, Kimball SR, Cavener DR, Jefferson LS.

Physiol Genomics. 2009 Aug 7;38(3):328-41. doi: 10.1152/physiolgenomics.90396.2008. Epub 2009 Jun 9.

PMID:
19509078
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.

Berlanga JJ, Santoyo J, De Haro C.

Eur J Biochem. 1999 Oct;265(2):754-62.

PMID:
10504407
[PubMed - indexed for MEDLINE]
Free Article
13.

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

Visweswaraiah J, Lee SJ, Hinnebusch AG, Sattlegger E.

J Biol Chem. 2012 Nov 2;287(45):37757-68. doi: 10.1074/jbc.M112.368266. Epub 2012 Aug 10.

PMID:
22888004
[PubMed - indexed for MEDLINE]
Free PMC Article
14.
15.

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR.

Mol Cell Biol. 2002 Oct;22(19):6681-8.

PMID:
12215525
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Lu W, László CF, Miao Z, Chen H, Wu S.

J Biol Chem. 2009 Sep 4;284(36):24281-8. doi: 10.1074/jbc.M109.008821. Epub 2009 Jul 8.

PMID:
19586904
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.

Roffé M, Hajj GN, Azevedo HF, Alves VS, Castilho BA.

J Biol Chem. 2013 Apr 12;288(15):10860-9. doi: 10.1074/jbc.M113.461970. Epub 2013 Feb 27.

PMID:
23447528
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Overview of the molecular and biochemical basis of branched-chain amino acid catabolism.

Harris RA, Joshi M, Jeoung NH, Obayashi M.

J Nutr. 2005 Jun;135(6 Suppl):1527S-30S. Review.

PMID:
15930464
[PubMed - indexed for MEDLINE]
Free Article
19.

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

Kubota H, Obata T, Ota K, Sasaki T, Ito T.

J Biol Chem. 2003 Jun 6;278(23):20457-60. Epub 2003 Apr 2.

PMID:
12676950
[PubMed - indexed for MEDLINE]
Free Article
20.

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.

Pereira CM, Sattlegger E, Jiang HY, Longo BM, Jaqueta CB, Hinnebusch AG, Wek RC, Mello LE, Castilho BA.

J Biol Chem. 2005 Aug 5;280(31):28316-23. Epub 2005 Jun 2.

PMID:
15937339
[PubMed - indexed for MEDLINE]
Free Article

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