Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 92


Using molecular features of xenobiotics to predict hepatic gene expression response.

Fernald GH, Altman RB.

J Chem Inf Model. 2013 Oct 28;53(10):2765-73. doi: 10.1021/ci3005868. Epub 2013 Oct 2.


Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.

Guzelian J, Barwick JL, Hunter L, Phang TL, Quattrochi LC, Guzelian PS.

Toxicol Sci. 2006 Dec;94(2):379-87. Epub 2006 Sep 22.


Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.


A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.

Bailey I, Gibson GG, Plant K, Graham M, Plant N.

PLoS One. 2011 Feb 2;6(2):e16703. doi: 10.1371/journal.pone.0016703.


Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes.

Pavlica S, Schmitmeier S, Gloeckner P, Piscioneri A, Peinemann F, Krohn K, Siegmund-Schulz M, Laera S, Favia P, Bartolo LD, Bader A.

J Tissue Eng Regen Med. 2012 Jun;6(6):486-96. doi: 10.1002/term.453. Epub 2011 Jul 13.


Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.

Jessen BA, Mullins JS, De Peyster A, Stevens GJ.

Toxicol Sci. 2003 Sep;75(1):208-22. Epub 2003 Jun 27.


Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice.

Moriya N, Kataoka H, Fujino H, Nishikawa J, Kugawa F.

Biol Pharm Bull. 2012;35(4):473-80.


In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens.

Heise T, Schug M, Storm D, Ellinger-Ziegelbauer H, Ahr HJ, Hellwig B, Rahnenfuhrer J, Ghallab A, Guenther G, Sisnaiske J, Reif R, Godoy P, Mielke H, Gundert-Remy U, Lampen A, Oberemm A, Hengstler JG.

Curr Med Chem. 2012;19(11):1721-30.


Cytochrome p450 expression of cultured rat small hepatocytes after long-term cryopreservation.

Ooe H, Kon J, Miyamoto S, Ozone Y, Ninomiya S, Mitaka T.

Drug Metab Dispos. 2006 Oct;34(10):1667-71. Epub 2006 Jul 25.


TCDD dysregulation of 13 AHR-target genes in rat liver.

Watson JD, Prokopec SD, Smith AB, Okey AB, Pohjanvirta R, Boutros PC.

Toxicol Appl Pharmacol. 2014 Feb 1;274(3):445-54. doi: 10.1016/j.taap.2013.12.004. Epub 2013 Dec 16.


p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.

Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD.

Toxicol Sci. 2006 Dec;94(2):272-80. Epub 2006 Sep 25.


Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.

Buetler TM, Bammler TK, Hayes JD, Eaton DL.

Cancer Res. 1996 May 15;56(10):2306-13.


Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes.

Courtois A, Payen L, Le Ferrec E, Scheffer GL, Trinquart Y, Guillouzo A, Fardel O.

Biochem Pharmacol. 2002 Jan 15;63(2):333-41.


Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes.

de Longueville F, Atienzar FA, Marcq L, Dufrane S, Evrard S, Wouters L, Leroux F, Bertholet V, Gerin B, Whomsley R, Arnould T, Remacle J, Canning M.

Toxicol Sci. 2003 Oct;75(2):378-92. Epub 2003 Jul 25.


Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.

Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):329-46. doi: 10.1080/10937404.2010.483949.


Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology.

Hartley DP, Klaassen CD.

Drug Metab Dispos. 2000 May;28(5):608-16. Erratum in: Drug Metab Dispos 2000 Aug;28(8):1007.


Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O.

Drug Metab Dispos. 2006 Oct;34(10):1756-63. Epub 2006 Jul 12.

Items per page

Supplemental Content

Write to the Help Desk