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Results: 1 to 20 of 126

1.

Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold.

Li Y, Frank EH, Wang Y, Chubinskaya S, Huang HH, Grodzinsky AJ.

Osteoarthritis Cartilage. 2013 Dec;21(12):1933-41. doi: 10.1016/j.joca.2013.08.021. Epub 2013 Sep 3.

PMID:
24007885
[PubMed - indexed for MEDLINE]
2.

Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines.

Lu YC, Evans CH, Grodzinsky AJ.

Arthritis Res Ther. 2011;13(5):R142. doi: 10.1186/ar3456. Epub 2011 Sep 2.

PMID:
21888631
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.

Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY, Lark MW, Grodzinsky AJ.

Arthritis Rheum. 2009 Oct;60(10):2985-96. doi: 10.1002/art.24857.

PMID:
19790045
[PubMed - indexed for MEDLINE]
Free Article
4.

Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants.

Stevens AL, Wheeler CA, Tannenbaum SR, Grodzinsky AJ.

Osteoarthritis Cartilage. 2008 Apr;16(4):489-97. Epub 2007 Oct 10.

PMID:
17923423
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines.

Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR.

Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi: 10.1002/art.38378.

PMID:
24470357
[PubMed - indexed for MEDLINE]
7.

Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.

Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ.

Arthritis Rheum. 2003 May;48(5):1292-301.

PMID:
12746902
[PubMed - indexed for MEDLINE]
Free Article
8.

Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β.

Duesterdieck-Zellmer KF, Driscoll N, Ott JF.

Am J Vet Res. 2012 Oct;73(10):1530-9.

PMID:
23013178
[PubMed - indexed for MEDLINE]
9.

Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.

Porée B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann DJ, Malléin-Gerin F, Pujol JP, Boumediene K, Galéra P.

J Biol Chem. 2008 Feb 22;283(8):4850-65. Epub 2007 Dec 7.

PMID:
18065760
[PubMed - indexed for MEDLINE]
Free Article
10.

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.

Karsdal MA, Sumer EU, Wulf H, Madsen SH, Christiansen C, Fosang AJ, Sondergaard BC.

Arthritis Rheum. 2007 May;56(5):1549-58.

PMID:
17469134
[PubMed - indexed for MEDLINE]
Free Article
11.

IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage.

Flannery CR, Little CB, Hughes CE, Curtis CL, Caterson B, Jones SA.

Matrix Biol. 2000 Nov;19(6):549-53.

PMID:
11068209
[PubMed - indexed for MEDLINE]
12.

Influence of pro-inflammatory (IL-1 alpha, IL-6, TNF-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function.

Schuerwegh AJ, Dombrecht EJ, Stevens WJ, Van Offel JF, Bridts CH, De Clerck LS.

Osteoarthritis Cartilage. 2003 Sep;11(9):681-7.

PMID:
12954239
[PubMed - indexed for MEDLINE]
Free Article
13.

Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes.

Kim JH, Huh JE, Baek YH, Lee JD, Choi DY, Park DS.

J Ethnopharmacol. 2011 Mar 24;134(2):234-42. doi: 10.1016/j.jep.2010.12.005. Epub 2010 Dec 21.

PMID:
21182922
[PubMed - indexed for MEDLINE]
14.

Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs.

Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA.

Arthritis Res Ther. 2010;12(3):R82. doi: 10.1186/ar3009. Epub 2010 May 12.

PMID:
20462435
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro.

Müller RD, John T, Kohl B, Oberholzer A, Gust T, Hostmann A, Hellmuth M, Laface D, Hutchins B, Laube G, Veh RW, Tschoeke SK, Ertel W, Schulze-Tanzil G.

Cytokine. 2008 Dec;44(3):377-85. doi: 10.1016/j.cyto.2008.10.012. Epub 2008 Nov 20.

PMID:
19026560
[PubMed - indexed for MEDLINE]
17.

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.

Caramés B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M.

Arthritis Rheum. 2012 Apr;64(4):1182-92. doi: 10.1002/art.33444. Epub 2011 Oct 27.

PMID:
22034068
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown.

Rowan AD, Koshy PJ, Shingleton WD, Degnan BA, Heath JK, Vernallis AB, Spaull JR, Life PF, Hudson K, Cawston TE.

Arthritis Rheum. 2001 Jul;44(7):1620-32.

PMID:
11465713
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

Intermittent compressive strain may reduce aggrecanase expression in cartilage: a study of chondrocytes in agarose gel.

Mio K, Saito S, Tomatsu T, Toyama Y.

Clin Orthop Relat Res. 2005 Apr;(433):225-32.

PMID:
15805962
[PubMed - indexed for MEDLINE]

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