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Results: 1 to 20 of 108

1.

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.

Lefebvre V, Du Q, Baird S, Ng AC, Nascimento M, Campanella M, McBride HM, Screaton RA.

Autophagy. 2013 Nov 1;9(11):1770-9. doi: 10.4161/auto.25413. Epub 2013 Aug 7.

PMID:
24005319
[PubMed - indexed for MEDLINE]
2.

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.

Bertolin G, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K, Greene AW, Dauphin A, Waharte F, Bayot A, Salamero J, Lombès A, Bulteau AL, Fon EA, Brice A, Corti O.

Autophagy. 2013 Nov 1;9(11):1801-17. doi: 10.4161/auto.25884. Epub 2013 Sep 5.

PMID:
24149440
[PubMed - indexed for MEDLINE]
Free Article
3.

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.

Jin SM, Youle RJ.

Autophagy. 2013 Nov 1;9(11):1750-7. doi: 10.4161/auto.26122. Epub 2013 Sep 5.

PMID:
24149988
[PubMed - indexed for MEDLINE]
4.

The reciprocal roles of PARK2 and mitofusins in mitophagy and mitochondrial spheroid formation.

Yin XM, Ding WX.

Autophagy. 2013 Nov 1;9(11):1687-92. doi: 10.4161/auto.24871. Epub 2013 May 21. Review.

PMID:
24162069
[PubMed - indexed for MEDLINE]
5.

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ.

Nature. 2013 Dec 12;504(7479):291-5. doi: 10.1038/nature12748. Epub 2013 Nov 24.

PMID:
24270810
[PubMed - indexed for MEDLINE]
6.

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons.

Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C.

J Biol Chem. 2013 Jan 25;288(4):2223-37. doi: 10.1074/jbc.M112.391680. Epub 2012 Dec 4.

PMID:
23212910
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy.

Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK.

Autophagy. 2012 Oct;8(10):1462-76. doi: 10.4161/auto.21211. Epub 2012 Aug 14.

PMID:
22889933
[PubMed - indexed for MEDLINE]
Free Article
8.

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy.

Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW.

Hum Mol Genet. 2010 Dec 15;19(24):4861-70. doi: 10.1093/hmg/ddq419. Epub 2010 Sep 24. Erratum in: Hum Mol Genet. 2013 Apr 15;22(8):1697.

PMID:
20871098
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mitophagy in cells with mtDNA mutations: being sick is not enough.

de Vries RL, Gilkerson RW, Przedborski S, Schon EA.

Autophagy. 2012 Apr;8(4):699-700. doi: 10.4161/auto.19470. Epub 2012 Apr 1.

PMID:
22361618
[PubMed - indexed for MEDLINE]
10.

Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons.

Cai Q, Zakaria HM, Sheng ZH.

Autophagy. 2012 Jun;8(6):976-8. doi: 10.4161/auto.20218. Epub 2012 Jun 1.

PMID:
22739253
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.

Ivatt RM, Sanchez-Martinez A, Godena VK, Brown S, Ziviani E, Whitworth AJ.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8494-9. doi: 10.1073/pnas.1321207111. Epub 2014 May 27.

PMID:
24912190
[PubMed - in process]
Free PMC Article
12.

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.

Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N.

Sci Rep. 2012;2:1002. doi: 10.1038/srep01002. Epub 2012 Dec 19.

PMID:
23256036
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.

Narendra D, Walker JE, Youle R.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a011338. doi: 10.1101/cshperspect.a011338.

PMID:
23125018
[PubMed - indexed for MEDLINE]
14.

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both.

Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ.

Autophagy. 2010 Nov;6(8):1090-106.

PMID:
20890124
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.

Vincow ES, Merrihew G, Thomas RE, Shulman NJ, Beyer RP, MacCoss MJ, Pallanck LJ.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6400-5. doi: 10.1073/pnas.1221132110. Epub 2013 Mar 18.

PMID:
23509287
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction.

Piquereau J, Godin R, Deschênes S, Bessi VL, Mofarrahi M, Hussain SN, Burelle Y.

Autophagy. 2013 Nov 1;9(11):1837-51. doi: 10.4161/auto.26502. Epub 2013 Oct 3.

PMID:
24121678
[PubMed - indexed for MEDLINE]
17.

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.

Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C.

Hum Mol Genet. 2010 Aug 15;19(16):3124-37. doi: 10.1093/hmg/ddq215. Epub 2010 May 27.

PMID:
20508036
[PubMed - indexed for MEDLINE]
Free Article
18.

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.

Fu M, St-Pierre P, Shankar J, Wang PT, Joshi B, Nabi IR.

Mol Biol Cell. 2013 Apr;24(8):1153-62. doi: 10.1091/mbc.E12-08-0607. Epub 2013 Feb 20.

PMID:
23427266
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.

Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.

J Cell Biol. 2010 Apr 19;189(2):211-21. doi: 10.1083/jcb.200910140.

PMID:
20404107
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Parkin-induced mitophagy in the pathogenesis of Parkinson disease.

Narendra D, Tanaka A, Suen DF, Youle RJ.

Autophagy. 2009 Jul;5(5):706-8. Epub 2009 Jul 22.

PMID:
19377297
[PubMed - indexed for MEDLINE]
Free Article

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