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Results: 1 to 20 of 96

1.

Detection of QT prolongation through approximation of the T wave on Gaussian mixture modeling.

Hibino S, Ueda N, Horiba M, Yasui K, Kagamihara Y, Funahashi S, Kamiya K, Honda H.

Circ J. 2013;77(11):2728-35. Epub 2013 Aug 28.

PMID:
23986028
[PubMed - indexed for MEDLINE]
Free Article
2.

Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects.

Davis JD, Hackman F, Layton G, Higgins T, Sudworth D, Weissgerber G.

Br J Clin Pharmacol. 2008 Apr;65 Suppl 1:68-75. doi: 10.1111/j.1365-2125.2008.03138.x.

PMID:
18333868
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Effect of nalmefene 20 and 80 mg on the corrected QT interval and T-wave morphology: a randomized, double-blind, parallel-group, placebo- and moxifloxacin-controlled, single-centre study.

Matz J, Graff C, Vainio PJ, Kallio A, Højer AM, Struijk JJ, Kanters JK, Andersen MP, Toft E.

Clin Drug Investig. 2011 Nov 1;31(11):799-811. doi: 10.2165/11592950-000000000-00000.

PMID:
21967071
[PubMed - indexed for MEDLINE]
4.

Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin.

Holzgrefe HH, Cavero I, Buchanan LV, Gill MW, Durham SK.

J Pharmacol Toxicol Methods. 2007 May-Jun;55(3):227-37. Epub 2006 Sep 15.

PMID:
17097307
[PubMed - indexed for MEDLINE]
5.

Ipragliflozin does not prolong QTc interval in healthy male and female subjects: a phase I study.

Zhang W, Smulders R, Abeyratne A, Dietz A, Krauwinkel W, Kadokura T, Keirns J.

Clin Ther. 2013 Aug;35(8):1150-1161.e3. doi: 10.1016/j.clinthera.2013.06.009. Epub 2013 Aug 2.

PMID:
23910665
[PubMed - indexed for MEDLINE]
6.

Control of rapid heart rate changes for electrocardiographic analysis: implications for thorough QT studies.

Extramiana F, Maison-Blanche P, Haggui A, Badilini F, Beaufils P, Leenhardt A.

Clin Cardiol. 2006 Dec;29(12):534-9.

PMID:
17190179
[PubMed - indexed for MEDLINE]
7.

Lack of effect of aprepitant or its prodrug fosaprepitant on QTc intervals in healthy subjects.

Marbury TC, Jin B, Panebianco D, Murphy MG, Sun H, Evans JK, Han TH, Constanzer ML, Dru J, Shadle CR.

Anesth Analg. 2009 Aug;109(2):418-25. doi: 10.1213/ane.0b013e3181ac1066.

PMID:
19608812
[PubMed - indexed for MEDLINE]
8.

Clinical assessment of drug-induced QT prolongation in association with heart rate changes.

Extramiana F, Maison-Blanche P, Cabanis MJ, Ortemann-Renon C, Beaufils P, Leenhardt A.

Clin Pharmacol Ther. 2005 Apr;77(4):247-58.

PMID:
15903123
[PubMed - indexed for MEDLINE]
9.

Eltrombopag does not affect cardiac repolarization: results from a definitive QTc study in healthy subjects.

Matthys G, Park JW, McGuire S, Wire MB, Zhang J, Bowen C, Williams D, Jenkins JM, Peng B.

Br J Clin Pharmacol. 2010 Jul;70(1):24-33. doi: 10.1111/j.1365-2125.2010.03646.x.

PMID:
20642544
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects.

Dixon R, Job S, Oliver R, Tompson D, Wright JG, Maltby K, Lorch U, Taubel J.

Br J Clin Pharmacol. 2008 Sep;66(3):396-404. doi: 10.1111/j.1365-2125.2008.03250.x. Epub 2008 Jul 23.

PMID:
18662287
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Comparison of the four formulas of adjusting QT interval for the heart rate in the middle-aged healthy Turkish men.

Dogan A, Tunc E, Varol E, Ozaydin M, Ozturk M.

Ann Noninvasive Electrocardiol. 2005 Apr;10(2):134-41.

PMID:
15842424
[PubMed - indexed for MEDLINE]
12.

Moxifloxacin versus placebo modeling of the QT interval.

Grosjean P, Urien S.

J Pharmacokinet Pharmacodyn. 2012 Apr;39(2):205-15. doi: 10.1007/s10928-012-9242-8. Epub 2012 Feb 17.

PMID:
22350254
[PubMed - indexed for MEDLINE]
13.

Automated QT analysis that learns from cardiologist annotations.

Strachan IG, Hughes NP, Poonawala MH, Mason JW, Tarassenko L.

Ann Noninvasive Electrocardiol. 2009 Jan;14 Suppl 1:S9-21. doi: 10.1111/j.1542-474X.2008.00259.x.

PMID:
19143745
[PubMed - indexed for MEDLINE]
14.

Period correction of the QTc of moxifloxacin with multiple predose baseline ECGs is the least variable of 4 methods tested.

Zhang X, Silkey M, Schumacher M, Wang L, Raval H, Caulfield JP.

J Clin Pharmacol. 2009 May;49(5):534-9. doi: 10.1177/0091270008330158. Epub 2009 Mar 13.

PMID:
19287043
[PubMed - indexed for MEDLINE]
15.

Improving the precision of QT measurements.

Darpo B, Fossa AA, Couderc JP, Zhou M, Schreyer A, Ticktin M, Zapesochny A.

Cardiol J. 2011;18(4):401-10.

PMID:
21769821
[PubMed - indexed for MEDLINE]
Free Article
16.

Effects of the selective alpha 1a-adrenoceptor antagonist silodosin on ECGs of healthy men in a randomized, double-blind, placebo- and moxifloxacin-controlled study.

Morganroth J, Lepor H, Hill LA, Volinn W, Hoel G.

Clin Pharmacol Ther. 2010 May;87(5):609-13. doi: 10.1038/clpt.2009.265. Epub 2010 Mar 10.

PMID:
20220748
[PubMed - indexed for MEDLINE]
17.

Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers.

Loghin C, Haber H, Beasley CM Jr, Kothare PA, Kauffman L, April J, Jin L, Allen AJ, Mitchell MI.

Br J Clin Pharmacol. 2013 Feb;75(2):538-49. doi: 10.1111/j.1365-2125.2012.04382.x.

PMID:
22803597
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Thorough QT/QTc study in patients with advanced Parkinson's disease: cardiac safety of rotigotine.

Malik M, Andreas JO, Hnatkova K, Hoeckendorff J, Cawello W, Middle M, Horstmann R, Braun M.

Clin Pharmacol Ther. 2008 Nov;84(5):595-603. doi: 10.1038/clpt.2008.143. Epub 2008 Jul 23.

PMID:
18650802
[PubMed - indexed for MEDLINE]
19.

Highly automated QT measurement techniques in 7 thorough QT studies implemented under ICH E14 guidelines.

Couderc JP, Garnett C, Li M, Handzel R, McNitt S, Xia X, Polonsky S, Zareba W.

Ann Noninvasive Electrocardiol. 2011 Jan;16(1):13-24. doi: 10.1111/j.1542-474X.2010.00402.x.

PMID:
21251129
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Evaluation of the effects of bitopertin (RG1678) on cardiac repolarization: a thorough corrected QT study in healthy male volunteers.

Hofmann C, Banken L, Hahn M, Swearingen D, Nagel S, Martin-Facklam M.

Clin Ther. 2012 Oct;34(10):2061-71. doi: 10.1016/j.clinthera.2012.08.010. Epub 2012 Sep 12.

PMID:
22980315
[PubMed - indexed for MEDLINE]

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