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Items: 1 to 20 of 101

1.

Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.

Yang P, Li X, Xu C, Eckert RL, Reece EA, Zielke HR, Wang F.

Sci Signal. 2013 Aug 27;6(290):ra74. doi: 10.1126/scisignal.2004020.

2.

Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy.

Wang F, Weng H, Quon MJ, Yu J, Wang JY, Hueber AO, Yang P.

Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29.

PMID:
26419589
3.

Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.

Wang F, Reece EA, Yang P.

Am J Obstet Gynecol. 2015 Aug;213(2):125-34. doi: 10.1016/j.ajog.2015.01.016. Epub 2015 Jan 13. Review.

PMID:
25595581
4.

Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling.

Yang P, Reece EA, Wang F, Gabbay-Benziv R.

Am J Obstet Gynecol. 2015 May;212(5):569-79. doi: 10.1016/j.ajog.2014.11.036. Epub 2014 Nov 27. Review.

5.

ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.

Wang F, Wu Y, Quon MJ, Li X, Yang P.

Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99. doi: 10.1152/ajpendo.00121.2015. Epub 2015 Jul 14.

PMID:
26173459
6.

Advances in understanding the molecular causes of diabetes-induced birth defects.

Loeken MR.

J Soc Gynecol Investig. 2006 Jan;13(1):2-10. Epub 2005 Nov 21.

PMID:
16303321
7.

Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy.

Li X, Weng H, Xu C, Reece EA, Yang P.

Diabetes. 2012 Aug;61(8):2084-92. doi: 10.2337/db11-1624. Epub 2012 Jun 11.

8.

Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo.

Harada C, Nakamura K, Namekata K, Okumura A, Mitamura Y, Iizuka Y, Kashiwagi K, Yoshida K, Ohno S, Matsuzawa A, Tanaka K, Ichijo H, Harada T.

Am J Pathol. 2006 Jan;168(1):261-9.

9.

c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy.

Li X, Xu C, Yang P.

Diabetes. 2013 Feb;62(2):599-608. doi: 10.2337/db12-0026. Epub 2012 Sep 6.

10.

Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis.

Gabbay-Benziv R, Reece EA, Wang F, Yang P.

World J Diabetes. 2015 Apr 15;6(3):481-8. doi: 10.4239/wjd.v6.i3.481. Review.

11.

Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome.

Wang F, Wu Y, Gu H, Reece EA, Fang S, Gabbay-Benziv R, Aberdeen G, Yang P.

Diabetes. 2015 Mar;64(3):973-88. doi: 10.2337/db14-0409. Epub 2014 Sep 23.

12.

Protein kinase Cβ2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway.

Cao Y, Zhao Z, Eckert RL, Reece EA.

Am J Obstet Gynecol. 2011 Mar;204(3):226.e1-5. doi: 10.1016/j.ajog.2011.01.013.

13.

Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis.

Pramanik KC, Srivastava SK.

Antioxid Redox Signal. 2012 Nov 15;17(10):1417-32. doi: 10.1089/ars.2011.4369. Epub 2012 Jun 11.

14.

Caspase-8: a key role in the pathogenesis of diabetic embryopathy.

Zhao Z, Yang P, Eckert RL, Reece EA.

Birth Defects Res B Dev Reprod Toxicol. 2009 Feb;86(1):72-7. doi: 10.1002/bdrb.20185.

15.

Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells.

Yokoi T, Fukuo K, Yasuda O, Hotta M, Miyazaki J, Takemura Y, Kawamoto H, Ichijo H, Ogihara T.

Diabetes. 2006 Jun;55(6):1660-5.

16.

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.

Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M.

Gastroenterology. 2008 Oct;135(4):1311-21. doi: 10.1053/j.gastro.2008.07.006. Epub 2008 Jul 9.

PMID:
18700144
17.
18.

Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects.

Zhong J, Reece EA, Yang P.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):179-84. doi: 10.1016/j.bbrc.2015.10.024. Epub 2015 Oct 13.

PMID:
26453010
19.
20.

Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells.

Shi Y, Ren Y, Zhao L, Du C, Wang Y, Zhang Y, Li Y, Zhao S, Duan H.

FEBS Lett. 2011 Jun 23;585(12):1789-95. doi: 10.1016/j.febslet.2011.04.021. Epub 2011 Apr 15. Erratum in: FEBS Lett. 2013 Mar 18;587(6):820-1.

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