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Results: 1 to 20 of 271

1.

Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents.

Hashiguchi Y, Hamada A, Shinohara T, Tsuchiya K, Jono H, Saito H.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):221-7. doi: 10.1016/j.bbrc.2013.08.054. Epub 2013 Aug 24.

PMID:
23981805
[PubMed - indexed for MEDLINE]
2.

P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines.

Fujimoto H, Higuchi M, Watanabe H, Koh Y, Ghosh AK, Mitsuya H, Tanoue N, Hamada A, Saito H.

Biol Pharm Bull. 2009 Sep;32(9):1588-93.

PMID:
19721237
[PubMed - indexed for MEDLINE]
Free Article
3.

P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir.

Janneh O, Anwar T, Jungbauer C, Kopp S, Khoo SH, Back DJ, Chiba P.

Antivir Ther. 2009;14(7):965-74. doi: 10.3851/IMP1399.

PMID:
19918100
[PubMed - indexed for MEDLINE]
4.

Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes.

Janneh O, Jones E, Chandler B, Owen A, Khoo SH.

J Antimicrob Chemother. 2007 Nov;60(5):987-93. Epub 2007 Sep 21.

PMID:
17890284
[PubMed - indexed for MEDLINE]
Free Article
5.

Utility of P-glycoprotein and organic cation transporter 1 double-transfected LLC-PK1 cells for studying the interaction of YM155 monobromide, novel small-molecule survivin suppressant, with P-glycoprotein.

Iwai M, Minematsu T, Li Q, Iwatsubo T, Usui T.

Drug Metab Dispos. 2011 Dec;39(12):2314-20. doi: 10.1124/dmd.111.040733. Epub 2011 Sep 14.

PMID:
21918035
[PubMed - indexed for MEDLINE]
Free Article
6.

Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier.

van der Sandt IC, Vos CM, Nabulsi L, Blom-Roosemalen MC, Voorwinden HH, de Boer AG, Breimer DD.

AIDS. 2001 Mar 9;15(4):483-91.

PMID:
11242145
[PubMed - indexed for MEDLINE]
7.

Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes.

Janneh O, Chandler B, Hartkoorn R, Kwan WS, Jenkinson C, Evans S, Back DJ, Owen A, Khoo SH.

J Antimicrob Chemother. 2009 Nov;64(5):1002-7. doi: 10.1093/jac/dkp335. Epub 2009 Sep 11.

PMID:
19748977
[PubMed - indexed for MEDLINE]
Free Article
8.

Inhibitory effect of human immunodeficiency virus protease inhibitors on multidrug resistance transporter P-glycoproteins.

Shiraki N, Hamada A, Yasuda K, Fujii J, Arimori K, Nakano M.

Biol Pharm Bull. 2000 Dec;23(12):1528-31.

PMID:
11145192
[PubMed - indexed for MEDLINE]
9.

Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactions.

Kis O, Zastre JA, Hoque MT, Walmsley SL, Bendayan R.

Pharm Res. 2013 Apr;30(4):1050-64. doi: 10.1007/s11095-012-0942-y. Epub 2012 Dec 7.

PMID:
23224979
[PubMed - indexed for MEDLINE]
10.

Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.

Mandíková J, Volková M, Pávek P, Česnek M, Janeba Z, Kubíček V, Trejtnar F.

Toxicology. 2013 Sep 15;311(3):135-46. doi: 10.1016/j.tox.2013.07.004. Epub 2013 Jul 13.

PMID:
23856525
[PubMed - indexed for MEDLINE]
11.

Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.

van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD.

Eur J Pharm Sci. 2000 Sep;11(3):207-14.

PMID:
11042226
[PubMed - indexed for MEDLINE]
12.

P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?

Jones K, Bray PG, Khoo SH, Davey RA, Meaden ER, Ward SA, Back DJ.

AIDS. 2001 Jul 27;15(11):1353-8.

PMID:
11504956
[PubMed - indexed for MEDLINE]
13.

Intestinal absorption mechanism of mirabegron, a potent and selective β₃-adrenoceptor agonist: involvement of human efflux and/or influx transport systems.

Takusagawa S, Ushigome F, Nemoto H, Takahashi Y, Li Q, Kerbusch V, Miyashita A, Iwatsubo T, Usui T.

Mol Pharm. 2013 May 6;10(5):1783-94. doi: 10.1021/mp300582s. Epub 2013 Apr 24.

PMID:
23560393
[PubMed - indexed for MEDLINE]
14.

pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions.

Kis O, Zastre JA, Ramaswamy M, Bendayan R.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):1009-22. doi: 10.1124/jpet.110.166314. Epub 2010 May 27.

PMID:
20507927
[PubMed - indexed for MEDLINE]
Free Article
15.

In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: implications for disposition and drug interactions.

Reyner EL, Sevidal S, West MA, Clouser-Roche A, Freiwald S, Fenner K, Ullah M, Lee CA, Smith BJ.

Drug Metab Dispos. 2013 Aug;41(8):1575-83. doi: 10.1124/dmd.113.051193. Epub 2013 May 31.

PMID:
23729661
[PubMed - indexed for MEDLINE]
Free Article
16.

Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y.

Br J Pharmacol. 2004 Dec;143(7):856-64. Epub 2004 Oct 25.

PMID:
15504753
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Expression of ATP-binding cassette membrane transporters in rodent and human sertoli cells: relevance to the permeability of antiretroviral therapy at the blood-testis barrier.

Robillard KR, Hoque T, Bendayan R.

J Pharmacol Exp Ther. 2012 Jan;340(1):96-108. doi: 10.1124/jpet.111.186916. Epub 2011 Oct 11.

PMID:
21990609
[PubMed - indexed for MEDLINE]
Free Article
19.

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB.

Drug Metab Dispos. 1999 Aug;27(8):866-71.

PMID:
10421612
[PubMed - indexed for MEDLINE]
Free Article
20.

Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein.

Brimer C, Dalton JT, Zhu Z, Schuetz J, Yasuda K, Vanin E, Relling MV, Lu Y, Schuetz EG.

Pharm Res. 2000 Jul;17(7):803-10.

PMID:
10990198
[PubMed - indexed for MEDLINE]

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