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Items: 1 to 20 of 109

1.

The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.

Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H.

J Am Chem Soc. 2013 Sep 25;135(38):14266-75. doi: 10.1021/ja405984v. Epub 2013 Sep 16.

2.

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles.

LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H.

Biochemistry. 2016 Feb 5. [Epub ahead of print]

PMID:
26811944
3.

Experimental conditions can obscure the second high-affinity site in LeuT.

Quick M, Shi L, Zehnpfennig B, Weinstein H, Javitch JA.

Nat Struct Mol Biol. 2012 Jan 15;19(2):207-11. doi: 10.1038/nsmb.2197.

4.

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.

Wang H, Elferich J, Gouaux E.

Nat Struct Mol Biol. 2012 Jan 15;19(2):212-9. doi: 10.1038/nsmb.2215.

5.

Structural origins of nitroxide side chain dynamics on membrane protein α-helical sites.

Kroncke BM, Horanyi PS, Columbus L.

Biochemistry. 2010 Nov 30;49(47):10045-60. doi: 10.1021/bi101148w. Epub 2010 Nov 8.

6.

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.

Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8. doi: 10.1073/pnas.0811322106. Epub 2009 Mar 23.

7.

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT.

Mondal S, Khelashvili G, Shi L, Weinstein H.

Chem Phys Lipids. 2013 Apr;169:27-38. doi: 10.1016/j.chemphyslip.2013.01.006. Epub 2013 Jan 30.

8.

Substrate and drug binding sites in LeuT.

Nyola A, Karpowich NK, Zhen J, Marden J, Reith ME, Wang DN.

Curr Opin Struct Biol. 2010 Aug;20(4):415-22. doi: 10.1016/j.sbi.2010.05.007. Epub 2010 Jun 16. Review.

9.

A competitive inhibitor traps LeuT in an open-to-out conformation.

Singh SK, Piscitelli CL, Yamashita A, Gouaux E.

Science. 2008 Dec 12;322(5908):1655-61. doi: 10.1126/science.1166777.

10.

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.

Loland CJ.

Biochim Biophys Acta. 2015 Mar;1850(3):500-10. doi: 10.1016/j.bbagen.2014.04.011. Epub 2014 Apr 24. Review.

PMID:
24769398
11.

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.

Zhao Y, Terry DS, Shi L, Quick M, Weinstein H, Blanchard SC, Javitch JA.

Nature. 2011 Jun 2;474(7349):109-13. doi: 10.1038/nature09971. Epub 2011 Apr 24.

12.

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters.

Penmatsa A, Gouaux E.

J Physiol. 2014 Mar 1;592(Pt 5):863-9. doi: 10.1113/jphysiol.2013.259051. Epub 2013 Jul 22. Review.

13.

Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologue.

Shaikh SA, Tajkhorshid E.

PLoS Comput Biol. 2010 Aug 26;6(8). pii: e1000905. doi: 10.1371/journal.pcbi.1000905.

14.

Analysis of the solution structure of Thermosynechococcus elongatus photosystem I in n-dodecyl-β-D-maltoside using small-angle neutron scattering and molecular dynamics simulation.

Le RK, Harris BJ, Iwuchukwu IJ, Bruce BD, Cheng X, Qian S, Heller WT, O'Neill H, Frymier PD.

Arch Biochem Biophys. 2014 May 15;550-551:50-7. doi: 10.1016/j.abb.2014.04.005. Epub 2014 Apr 24.

PMID:
24769336
15.

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

Piscitelli CL, Krishnamurthy H, Gouaux E.

Nature. 2010 Dec 23;468(7327):1129-32. doi: 10.1038/nature09581.

16.

NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT.

LeVine MV, Weinstein H.

PLoS Comput Biol. 2014 May 1;10(5):e1003603. doi: 10.1371/journal.pcbi.1003603. eCollection 2014 May.

17.

Molecular dynamics simulations of Na(+) and leucine transport by LeuT.

Chen R, Chung SH.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):281-5. doi: 10.1016/j.bbrc.2015.06.143. Epub 2015 Jun 24.

PMID:
26116773
18.

What is an antidepressant binding site doing in a bacterial transporter?

Rudnick G.

ACS Chem Biol. 2007 Sep 21;2(9):606-9. Review.

PMID:
17894444
19.

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS.

Nat Struct Mol Biol. 2010 Jul;17(7):822-9. doi: 10.1038/nsmb.1854. Epub 2010 Jun 20.

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