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Results: 1 to 20 of 108

1.

The TREX1 C-terminal region controls cellular localization through ubiquitination.

Orebaugh CD, Fye JM, Harvey S, Hollis T, Wilkinson JC, Perrino FW.

J Biol Chem. 2013 Oct 4;288(40):28881-92. doi: 10.1074/jbc.M113.503391. Epub 2013 Aug 26.

PMID:
23979357
[PubMed - indexed for MEDLINE]
2.

The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.

Orebaugh CD, Fye JM, Harvey S, Hollis T, Perrino FW.

J Biol Chem. 2011 Nov 18;286(46):40246-54. doi: 10.1074/jbc.M111.297903. Epub 2011 Sep 21.

PMID:
21937424
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.

Fye JM, Coffin SR, Orebaugh CD, Hollis T, Perrino FW.

J Biol Chem. 2014 Apr 18;289(16):11556-65. doi: 10.1074/jbc.M114.559252. Epub 2014 Mar 9.

PMID:
24616097
[PubMed - indexed for MEDLINE]
4.

Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.

Fye JM, Orebaugh CD, Coffin SR, Hollis T, Perrino FW.

J Biol Chem. 2011 Sep 16;286(37):32373-82. doi: 10.1074/jbc.M111.276287. Epub 2011 Aug 1.

PMID:
21808053
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.

Bailey SL, Harvey S, Perrino FW, Hollis T.

DNA Repair (Amst). 2012 Jan 2;11(1):65-73. doi: 10.1016/j.dnarep.2011.10.007. Epub 2011 Nov 8.

PMID:
22071149
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.

Lehtinen DA, Harvey S, Mulcahy MJ, Hollis T, Perrino FW.

J Biol Chem. 2008 Nov 14;283(46):31649-56. doi: 10.1074/jbc.M806155200. Epub 2008 Sep 18.

PMID:
18805785
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.

Lindahl T, Barnes DE, Yang YG, Robins P.

Biochem Soc Trans. 2009 Jun;37(Pt 3):535-8. doi: 10.1042/BST0370535.

PMID:
19442247
[PubMed - indexed for MEDLINE]
8.

Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.

Brucet M, Querol-Audí J, Serra M, Ramirez-Espain X, Bertlik K, Ruiz L, Lloberas J, Macias MJ, Fita I, Celada A.

J Biol Chem. 2007 May 11;282(19):14547-57. Epub 2007 Mar 13.

PMID:
17355961
[PubMed - indexed for MEDLINE]
Free Article
9.

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.

de Silva U, Choudhury S, Bailey SL, Harvey S, Perrino FW, Hollis T.

J Biol Chem. 2007 Apr 6;282(14):10537-43. Epub 2007 Feb 9.

PMID:
17293595
[PubMed - indexed for MEDLINE]
Free Article
10.

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N.

Nat Genet. 2007 Sep;39(9):1065-7. Epub 2007 Jul 29.

PMID:
17660818
[PubMed - indexed for MEDLINE]
11.

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.

Yang YG, Lindahl T, Barnes DE.

Cell. 2007 Nov 30;131(5):873-86.

PMID:
18045533
[PubMed - indexed for MEDLINE]
Free Article
12.

Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.

Brucet M, Querol-Audí J, Bertlik K, Lloberas J, Fita I, Celada A.

Protein Sci. 2008 Dec;17(12):2059-69. doi: 10.1110/ps.036426.108. Epub 2008 Sep 9.

PMID:
18780819
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

Ablasser A, Hemmerling I, Schmid-Burgk JL, Behrendt R, Roers A, Hornung V.

J Immunol. 2014 Jun 15;192(12):5993-7. doi: 10.4049/jimmunol.1400737. Epub 2014 May 9.

PMID:
24813208
[PubMed - indexed for MEDLINE]
14.

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.

Rice G, Newman WG, Dean J, Patrick T, Parmar R, Flintoff K, Robins P, Harvey S, Hollis T, O'Hara A, Herrick AL, Bowden AP, Perrino FW, Lindahl T, Barnes DE, Crow YJ.

Am J Hum Genet. 2007 Apr;80(4):811-5. Epub 2007 Feb 19.

PMID:
17357087
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations.

Goncalves A, Karayel E, Rice GI, Bennett KL, Crow YJ, Superti-Furga G, Bürckstümmer T.

Hum Mutat. 2012 Jul;33(7):1116-22. doi: 10.1002/humu.22087. Epub 2012 Apr 16.

PMID:
22461318
[PubMed - indexed for MEDLINE]
16.

Dysregulation of the immune system in Aicardi-Goutières syndrome: another example in a TREX1-mutated patient.

Olivieri I, Cattalini M, Tonduti D, La Piana R, Uggetti C, Galli J, Meini A, Tincani A, Moratto D, Fazzi E, Balottin U, Orcesi S.

Lupus. 2013 Sep;22(10):1064-9. doi: 10.1177/0961203313498800. Epub 2013 Aug 5.

PMID:
23918923
[PubMed - indexed for MEDLINE]
17.

Lysosomal localization of ubiquitinated Jun requires multiple determinants in a lysine-27-linked polyubiquitin conjugate.

Ikeda H, Kerppola TK.

Mol Biol Cell. 2008 Nov;19(11):4588-601. doi: 10.1091/mbc.E08-05-0496. Epub 2008 Aug 20.

PMID:
18716056
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2.

Ford DL, Monteiro MJ.

Biochemistry. 2007 Jul 31;46(30):8827-37. Epub 2007 Jul 6.

PMID:
17614368
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study.

Abe J, Nakamura K, Nishikomori R, Kato M, Mitsuiki N, Izawa K, Awaya T, Kawai T, Yasumi T, Toyoshima I, Hasegawa K, Ohshima Y, Hiragi T, Sasahara Y, Suzuki Y, Kikuchi M, Osaka H, Ohya T, Ninomiya S, Fujikawa S, Akasaka M, Iwata N, Kawakita A, Funatsuka M, Shintaku H, Ohara O, Ichinose H, Heike T.

Rheumatology (Oxford). 2014 Mar;53(3):448-58. doi: 10.1093/rheumatology/ket372. Epub 2013 Dec 3.

PMID:
24300241
[PubMed - indexed for MEDLINE]
20.

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB.

Immunity. 2012 Jan 27;36(1):120-31. doi: 10.1016/j.immuni.2011.11.018.

PMID:
22284419
[PubMed - indexed for MEDLINE]
Free PMC Article

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