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Results: 1 to 20 of 180

1.

Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase.

Jonigk D, Al-Omari M, Maegel L, Müller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15007-12. doi: 10.1073/pnas.1309648110. Epub 2013 Aug 23.

PMID:
23975926
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

High-density lipoproteins potentiate α1-antitrypsin therapy in elastase-induced pulmonary emphysema.

Moreno JA, Ortega-Gomez A, Rubio-Navarro A, Louedec L, Ho-Tin-Noé B, Caligiuri G, Nicoletti A, Levoye A, Plantier L, Meilhac O.

Am J Respir Cell Mol Biol. 2014 Oct;51(4):536-49. doi: 10.1165/rcmb.2013-0103OC.

PMID:
24787644
[PubMed - indexed for MEDLINE]
3.

Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route.

Hubbard RC, Crystal RG.

Lung. 1990;168 Suppl:565-78.

PMID:
2117165
[PubMed - indexed for MEDLINE]
4.

The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency.

Schmid ST, Koepke J, Dresel M, Hattesohl A, Frenzel E, Perez J, Lomas DA, Miranda E, Greulich T, Noeske S, Wencker M, Teschler H, Vogelmeier C, Janciauskiene S, Koczulla AR.

Int J Chron Obstruct Pulmon Dis. 2012;7:687-96. doi: 10.2147/COPD.S34560. Epub 2012 Sep 28.

PMID:
23055718
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.

Hubbard RC, McElvaney NG, Sellers SE, Healy JT, Czerski DB, Crystal RG.

J Clin Invest. 1989 Oct;84(4):1349-54.

PMID:
2794066
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.

Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, Condron C, Chotirmall SH, Clynes M, O'Neill SJ, McElvaney NG.

J Clin Invest. 2010 Dec;120(12):4236-50. doi: 10.1172/JCI41196. Epub 2010 Nov 8.

PMID:
21060150
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Prolastin, a pharmaceutical preparation of purified human alpha1-antitrypsin, blocks endotoxin-mediated cytokine release.

Nita I, Hollander C, Westin U, Janciauskiene SM.

Respir Res. 2005 Jan 31;6:12.

PMID:
15683545
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals.

Hurley K, Lacey N, O'Dwyer CA, Bergin DA, McElvaney OJ, O'Brien ME, McElvaney OF, Reeves EP, McElvaney NG.

J Immunol. 2014 Oct 15;193(8):3978-91. doi: 10.4049/jimmunol.1400132. Epub 2014 Sep 12.

PMID:
25217166
[PubMed - indexed for MEDLINE]
9.

Alpha-1 antitrypsin: now available, but do we need it?

Russi EW.

Swiss Med Wkly. 2008 Apr 5;138(13-14):191-6. doi: 2008/13/smw-11991. Review.

PMID:
18389391
[PubMed - indexed for MEDLINE]
Free Article
10.

Neutrophil recruitment into the lungs is associated with increased lung elastase burden, decreased lung elastin, and emphysema in alpha 1 proteinase inhibitor-deficient mice.

Cavarra E, Martorana PA, Gambelli F, de Santi M, van Even P, Lungarella G.

Lab Invest. 1996 Aug;75(2):273-80.

PMID:
8765327
[PubMed - indexed for MEDLINE]
11.

Effect of recombinant α1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes.

Lee S, Lee Y, Hong K, Hong J, Bae S, Choi J, Jhun H, Kwak A, Kim E, Jo S, Dinarello CA, Kim S.

Mol Med. 2013 May 20;19:65-71. doi: 10.2119/molmed.2012.00308.

PMID:
23552726
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice.

Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, Koga H, Nishimori H, Tanimoto Y, Kataoka M, Iwakura Y, Gelfand EW, Tanimoto M.

Respir Res. 2013 Jan 20;14:5. doi: 10.1186/1465-9921-14-5.

PMID:
23331548
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome?

Abboud RT, Ford GT, Chapman KR.

Treat Respir Med. 2005;4(1):1-8. Review.

PMID:
15725045
[PubMed - indexed for MEDLINE]
14.

Effects of alpha 1-antitrypsin on endotoxin-induced lung inflammation in vivo.

Subramaniyam D, Steele C, Köhnlein T, Welte T, Grip O, Matalon S, Janciauskiene S.

Inflamm Res. 2010 Jul;59(7):571-8. doi: 10.1007/s00011-010-0164-x. Epub 2010 Mar 18.

PMID:
20238140
[PubMed - indexed for MEDLINE]
15.

Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer.

Xu Y, Zhang J, Han J, Pan X, Cao Y, Guo H, Pan Y, An Y, Li X.

Mol Oncol. 2012 Aug;6(4):405-17. doi: 10.1016/j.molonc.2012.03.005. Epub 2012 Apr 2.

PMID:
22507634
[PubMed - indexed for MEDLINE]
Free Article
16.

Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse.

Pemberton PA, Kobayashi D, Wilk BJ, Henstrand JM, Shapiro SD, Barr PJ.

COPD. 2006 Jun;3(2):101-8.

PMID:
17175673
[PubMed - indexed for MEDLINE]
17.

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).

Hill AT, Campbell EJ, Bayley DL, Hill SL, Stockley RA.

Am J Respir Crit Care Med. 1999 Dec;160(6):1968-75.

PMID:
10588615
[PubMed - indexed for MEDLINE]
18.

Role of human neutrophil peptides in lung inflammation associated with alpha1-antitrypsin deficiency.

Spencer LT, Paone G, Krein PM, Rouhani FN, Rivera-Nieves J, Brantly ML.

Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L514-20. Epub 2003 Oct 31.

PMID:
14594730
[PubMed - indexed for MEDLINE]
Free Article
19.

Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis.

Martin SL, Downey D, Bilton D, Keogan MT, Edgar J, Elborn JS; Recombinant AAT CF Study Team.

Pediatr Pulmonol. 2006 Feb;41(2):177-83.

PMID:
16372352
[PubMed - indexed for MEDLINE]
20.

Alpha-1 antitrypsin augmentation therapy and biomarkers of elastin degradation.

Ma S, Lin YY, He J, Rouhani FN, Brantly M, Turino GM.

COPD. 2013 Aug;10(4):473-81. doi: 10.3109/15412555.2013.771163. Epub 2013 Apr 5.

PMID:
23560990
[PubMed - indexed for MEDLINE]
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