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Items: 1 to 20 of 210

1.

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.

Staats KA, Van Helleputte L, Jones AR, Bento-Abreu A, Van Hoecke A, Shatunov A, Simpson CL, Lemmens R, Jaspers T, Fukami K, Nakamura Y, Brown RH Jr, Van Damme P, Liston A, Robberecht W, Al-Chalabi A, Van Den Bosch L.

Neurobiol Dis. 2013 Dec;60:11-7. doi: 10.1016/j.nbd.2013.08.006. Epub 2013 Aug 19.

PMID:
23969236
2.

Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons.

Lautenschläger J, Prell T, Ruhmer J, Weidemann L, Witte OW, Grosskreutz J.

Exp Neurol. 2013 Sep;247:91-100. doi: 10.1016/j.expneurol.2013.03.027. Epub 2013 Apr 8.

PMID:
23578819
3.

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

Peviani M, Salvaneschi E, Bontempi L, Petese A, Manzo A, Rossi D, Salmona M, Collina S, Bigini P, Curti D.

Neurobiol Dis. 2014 Feb;62:218-32. doi: 10.1016/j.nbd.2013.10.010. Epub 2013 Oct 16.

PMID:
24141020
4.

Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.

Li QX, Mok SS, Laughton KM, McLean CA, Volitakis I, Cherny RA, Cheung NS, White AR, Masters CL.

Aging Cell. 2006 Apr;5(2):153-65.

5.

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, Rossi PI, Vergani L, Voci A, Conti F, Puliti A, Bonanno G.

Neurobiol Dis. 2014 Apr;64:48-59. doi: 10.1016/j.nbd.2013.11.006. Epub 2013 Dec 19.

6.

Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model.

Li Y, Guo Y, Wang X, Yu X, Duan W, Hong K, Wang J, Han H, Li C.

Neuroscience. 2015 Jul 9;298:12-25. doi: 10.1016/j.neuroscience.2015.03.061. Epub 2015 Apr 1.

PMID:
25841320
7.

Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model.

Turner BJ, Parkinson NJ, Davies KE, Talbot K.

Neurobiol Dis. 2009 Jun;34(3):511-7. doi: 10.1016/j.nbd.2009.03.005. Epub 2009 Mar 28.

PMID:
19332122
8.

Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS.

Yoshii Y, Otomo A, Pan L, Ohtsuka M, Hadano S.

Neurosci Res. 2011 Jul;70(3):321-9. doi: 10.1016/j.neures.2011.03.006. Epub 2011 Mar 29.

PMID:
21453731
9.

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.

Apolloni S, Amadio S, Montilli C, Volonté C, D'Ambrosi N.

Hum Mol Genet. 2013 Oct 15;22(20):4102-16. doi: 10.1093/hmg/ddt259. Epub 2013 Jun 4.

10.

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.

Pokrishevsky E, Grad LI, Yousefi M, Wang J, Mackenzie IR, Cashman NR.

PLoS One. 2012;7(4):e35050. doi: 10.1371/journal.pone.0035050. Epub 2012 Apr 6.

11.

GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis.

Carunchio I, Mollinari C, Pieri M, Merlo D, Zona C.

Eur J Neurosci. 2008 Oct;28(7):1275-85. doi: 10.1111/j.1460-9568.2008.06436.x.

PMID:
18973555
12.

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

Zhang X, Chen S, Song L, Tang Y, Shen Y, Jia L, Le W.

Autophagy. 2014 Apr;10(4):588-602. doi: 10.4161/auto.27710. Epub 2014 Jan 15.

13.

Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis.

Jiang HQ, Ren M, Jiang HZ, Wang J, Zhang J, Yin X, Wang SY, Qi Y, Wang XD, Feng HL.

Neuroscience. 2014 Sep 26;277:132-8. doi: 10.1016/j.neuroscience.2014.03.047. Epub 2014 Mar 31.

PMID:
24699224
14.

Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.

Shan X, Vocadlo D, Krieger C.

Neurosci Lett. 2009 Jul 17;458(2):70-4. doi: 10.1016/j.neulet.2009.04.031. Epub 2009 Apr 18.

PMID:
19379791
15.

Altered distribution and levels of cathepsinD and cystatins in amyotrophic lateral sclerosis transgenic mice: possible roles in motor neuron survival.

Wootz H, Weber E, Korhonen L, Lindholm D.

Neuroscience. 2006 Dec 1;143(2):419-30. Epub 2006 Sep 14.

PMID:
16973300
16.

Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Bryson JB, Hobbs C, Parsons MJ, Bosch KD, Pandraud A, Walsh FS, Doherty P, Greensmith L.

Hum Mol Genet. 2012 Sep 1;21(17):3871-82. doi: 10.1093/hmg/dds215. Epub 2012 Jun 7.

17.

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice.

Guo H, Lai L, Butchbach ME, Stockinger MP, Shan X, Bishop GA, Lin CL.

Hum Mol Genet. 2003 Oct 1;12(19):2519-32. Epub 2003 Aug 5.

18.

Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice.

Pan L, Yoshii Y, Otomo A, Ogawa H, Iwasaki Y, Shang HF, Hadano S.

PLoS One. 2012;7(3):e33409. doi: 10.1371/journal.pone.0033409. Epub 2012 Mar 16.

19.

Oxidative stress and autophagic alteration in brainstem of SOD1-G93A mouse model of ALS.

An T, Shi P, Duan W, Zhang S, Yuan P, Li Z, Wu D, Xu Z, Li C, Guo Y.

Mol Neurobiol. 2014 Jun;49(3):1435-48. doi: 10.1007/s12035-013-8623-3. Epub 2014 Jan 5.

PMID:
24390572
20.

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice.

Staats KA, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, Parys JB, Hisatsune C, Mikoshiba K, Van Damme P, Robberecht W, Van Den Bosch L.

Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):210-3. doi: 10.1016/j.bbrc.2012.10.094. Epub 2012 Nov 3.

PMID:
23131553
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