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Results: 1 to 20 of 377

1.

Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes.

Sullivan TJ, Miao Z, Zhao BN, Ertl LS, Wang Y, Krasinski A, Walters MJ, Powers JP, Dairaghi DJ, Baumgart T, Seitz LC, Berahovich RD, Schall TJ, Jaen JC.

Metabolism. 2013 Nov;62(11):1623-32. doi: 10.1016/j.metabol.2013.06.008. Epub 2013 Aug 15.

PMID:
23953944
[PubMed - indexed for MEDLINE]
2.

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice.

Kang YS, Lee MH, Song HK, Ko GJ, Kwon OS, Lim TK, Kim SH, Han SY, Han KH, Lee JE, Han JY, Kim HK, Cha DR.

Kidney Int. 2010 Nov;78(9):883-94. doi: 10.1038/ki.2010.263. Epub 2010 Aug 4.

PMID:
20686445
[PubMed - indexed for MEDLINE]
3.

Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

Tamura Y, Sugimoto M, Murayama T, Ueda Y, Kanamori H, Ono K, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2195-201. doi: 10.1161/ATVBAHA.108.168633. Epub 2008 Sep 25.

PMID:
18818420
[PubMed - indexed for MEDLINE]
Free Article
4.

Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice.

Feng B, Jiao P, Nie Y, Kim T, Jun D, van Rooijen N, Yang Z, Xu H.

PLoS One. 2011;6(9):e24358. doi: 10.1371/journal.pone.0024358. Epub 2011 Sep 12.

PMID:
21931688
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.

Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R.

Obesity (Silver Spring). 2010 Apr;18(4):780-7. doi: 10.1038/oby.2009.301. Epub 2009 Oct 1.

PMID:
19798065
[PubMed - indexed for MEDLINE]
6.

C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice.

Tamura Y, Sugimoto M, Murayama T, Minami M, Nishikaze Y, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H.

J Atheroscler Thromb. 2010 Mar 31;17(3):219-28. Epub 2010 Feb 24.

PMID:
20179360
[PubMed - indexed for MEDLINE]
Free Article
7.

Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice.

Saraswathi V, Ramnanan CJ, Wilks AW, Desouza CV, Eller AA, Murali G, Ramalingam R, Milne GL, Coate KC, Edgerton DS.

Metabolism. 2013 Nov;62(11):1673-85. doi: 10.1016/j.metabol.2013.07.007. Epub 2013 Aug 27.

PMID:
23987235
[PubMed - indexed for MEDLINE]
8.

Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice.

Fujita H, Fujishima H, Koshimura J, Hosoba M, Yoshioka N, Shimotomai T, Morii T, Narita T, Kakei M, Ito S.

Endocr J. 2005 Aug;52(4):427-33.

PMID:
16127210
[PubMed - indexed for MEDLINE]
Free Article
9.

Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice.

Jung UJ, Park YB, Kim SR, Choi MS.

PLoS One. 2012;7(11):e49030. doi: 10.1371/journal.pone.0049030. Epub 2012 Nov 8.

PMID:
23145054
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice.

Park HJ, Jung UJ, Cho SJ, Jung HK, Shim S, Choi MS.

J Nutr Biochem. 2013 Feb;24(2):419-27. doi: 10.1016/j.jnutbio.2011.12.009. Epub 2012 Jun 12.

PMID:
22694954
[PubMed - indexed for MEDLINE]
11.

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice.

Hellmann J, Tang Y, Kosuri M, Bhatnagar A, Spite M.

FASEB J. 2011 Jul;25(7):2399-407. doi: 10.1096/fj.10-178657. Epub 2011 Apr 8.

PMID:
21478260
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.

Sullivan T, Miao Z, Dairaghi DJ, Krasinski A, Wang Y, Zhao BN, Baumgart T, Ertl LS, Pennell A, Seitz L, Powers J, Zhao R, Ungashe S, Wei Z, Boring L, Tsou CL, Charo I, Berahovich RD, Schall TJ, Jaen JC.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1288-97. doi: 10.1152/ajprenal.00316.2013. Epub 2013 Aug 28.

PMID:
23986513
[PubMed - indexed for MEDLINE]
13.

Insulin sensitization via partial agonism of PPAR╬│ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats.

Gandhi GR, Stalin A, Balakrishna K, Ignacimuthu S, Paulraj MG, Vishal R.

Biochim Biophys Acta. 2013 Jan;1830(1):2243-55. doi: 10.1016/j.bbagen.2012.10.016. Epub 2012 Oct 24.

PMID:
23104384
[PubMed - indexed for MEDLINE]
Free Article
14.

An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice.

Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M.

Endocrinology. 2010 Mar;151(3):971-9. doi: 10.1210/en.2009-0926. Epub 2010 Jan 7.

PMID:
20056828
[PubMed - indexed for MEDLINE]
15.

Reversal of inflammation-induced impairment of glucose uptake in adipocytes by direct effect of CB1 antagonism on adipose tissue macrophages.

Miranville A, Herling AW, Biemer-Daub G, Voss MD.

Obesity (Silver Spring). 2010 Dec;18(12):2247-54. doi: 10.1038/oby.2010.81. Epub 2010 Apr 8.

PMID:
20379144
[PubMed - indexed for MEDLINE]
16.

Oral green tea catechins transiently lower plasma glucose concentrations in female db/db mice.

Wein S, Schrader E, Rimbach G, Wolffram S.

J Med Food. 2013 Apr;16(4):312-7. doi: 10.1089/jmf.2012.0205. Epub 2013 Mar 20.

PMID:
23514230
[PubMed - indexed for MEDLINE]
17.

The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice.

Hamada Y, Nagasaki H, Fuchigami M, Furuta S, Seino Y, Nakamura J, Oiso Y.

Metabolism. 2013 May;62(5):734-42. doi: 10.1016/j.metabol.2012.10.015. Epub 2012 Nov 26.

PMID:
23194643
[PubMed - indexed for MEDLINE]
18.

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y, Seethala R, Yang WP, Ren J, Zhou M, Ryono D, Biller S, Mookhtiar KA, Wetterau J, Gregg R, Cheng PT, Hariharan N.

Diabetes. 2006 Jan;55(1):240-8.

PMID:
16380499
[PubMed - indexed for MEDLINE]
Free Article
19.

Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice.

Muthulakshmi S, Saravanan R.

Biochimie. 2013 Jun;95(6):1239-44. doi: 10.1016/j.biochi.2013.01.018. Epub 2013 Feb 8.

PMID:
23402910
[PubMed - indexed for MEDLINE]
20.

Pharmacological evaluation of adipose dysfunction via 11╬▓-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation.

Akiyama N, Akiyama Y, Kato H, Kuroda T, Ono T, Imagawa K, Asakura K, Shinosaki T, Murayama T, Hanasaki K.

J Pharmacol Exp Ther. 2014 Apr;349(1):66-74. doi: 10.1124/jpet.113.210716. Epub 2014 Feb 7.

PMID:
24511146
[PubMed - indexed for MEDLINE]

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