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Results: 1 to 20 of 130

1.

Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.

Liu J, Lu YF, Zhang Y, Wu KC, Fan F, Klaassen CD.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):816-24. doi: 10.1016/j.taap.2013.08.003. Epub 2013 Aug 13.

PMID:
23948738
[PubMed - indexed for MEDLINE]
2.

Repeated oral administration of oleanolic acid produces cholestatic liver injury in mice.

Lu YF, Wan XL, Xu Y, Liu J.

Molecules. 2013 Mar 7;18(3):3060-71. doi: 10.3390/molecules18033060.

PMID:
23470335
[PubMed - indexed for MEDLINE]
Free Article
3.

Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.

Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD.

Toxicol Sci. 2012 Jun;127(2):451-62. doi: 10.1093/toxsci/kfs123. Epub 2012 Mar 29.

PMID:
22461449
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD.

Toxicol Sci. 2009 Jul;110(1):47-60. doi: 10.1093/toxsci/kfp094. Epub 2009 Apr 30.

PMID:
19407337
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of nuclear factor-E2-related factor 2-mediated upregulation of multidrug resistance-associated proteins.

Chen P, Zeng H, Wang Y, Fan X, Xu C, Deng R, Zhou X, Bi H, Huang M.

Drug Metab Dispos. 2014 May;42(5):844-52. doi: 10.1124/dmd.113.056549. Epub 2014 Feb 7.

PMID:
24510383
[PubMed - in process]
6.

Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism.

Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD.

Biochem Pharmacol. 2013 Aug 1;86(3):437-45. doi: 10.1016/j.bcp.2013.05.020. Epub 2013 Jun 6.

PMID:
23747753
[PubMed - indexed for MEDLINE]
7.

Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice.

Fu ZD, Klaassen CD.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):680-90. doi: 10.1016/j.taap.2013.10.020. Epub 2013 Oct 29.

PMID:
24183703
[PubMed - indexed for MEDLINE]
8.

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.

Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2063-8. Epub 2005 Jan 31.

PMID:
15684063
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARĪ±-, and Nrf2-null mice.

Aleksunes LM, Klaassen CD.

Drug Metab Dispos. 2012 Jul;40(7):1366-79. doi: 10.1124/dmd.112.045112. Epub 2012 Apr 11.

PMID:
22496397
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.

Wagner M, Halilbasic E, Marschall HU, Zollner G, Fickert P, Langner C, Zatloukal K, Denk H, Trauner M.

Hepatology. 2005 Aug;42(2):420-30.

PMID:
15986414
[PubMed - indexed for MEDLINE]
11.

ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.

Tanaka Y, Aleksunes LM, Cui YJ, Klaassen CD.

Toxicol Sci. 2009 Apr;108(2):247-57. doi: 10.1093/toxsci/kfp020. Epub 2009 Jan 29.

PMID:
19181614
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Gender-divergent profile of bile acid homeostasis during aging of mice.

Fu ZD, Csanaky IL, Klaassen CD.

PLoS One. 2012;7(3):e32551. doi: 10.1371/journal.pone.0032551. Epub 2012 Mar 5.

PMID:
22403674
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.

Cheng X, Klaassen CD.

Toxicol Sci. 2008 Nov;106(1):37-45. doi: 10.1093/toxsci/kfn161. Epub 2008 Aug 14.

PMID:
18703564
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.

Cheng X, Maher J, Dieter MZ, Klaassen CD.

Drug Metab Dispos. 2005 Sep;33(9):1276-82. Epub 2005 May 26.

PMID:
15919853
[PubMed - indexed for MEDLINE]
Free Article
15.

Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression.

Vanwijngaerden YM, Wauters J, Langouche L, Vander Perre S, Liddle C, Coulter S, Vanderborght S, Roskams T, Wilmer A, Van den Berghe G, Mesotten D.

Hepatology. 2011 Nov;54(5):1741-52. doi: 10.1002/hep.24582.

PMID:
21800341
[PubMed - indexed for MEDLINE]
16.

Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.

Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M.

J Biol Chem. 2006 Jun 16;281(24):16625-31. Epub 2006 Apr 10.

PMID:
16606610
[PubMed - indexed for MEDLINE]
Free Article
17.

Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.

Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL.

Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G925-36. doi: 10.1152/ajpgi.00263.2011. Epub 2012 Feb 16.

PMID:
22345550
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.

Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL.

Hepatology. 2010 Jan;51(1):181-90. doi: 10.1002/hep.23265.

PMID:
19902485
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation.

Jang JH, Rickenbacher A, Humar B, Weber A, Raptis DA, Lehmann K, Stieger B, Moritz W, Soll C, Georgiev P, Fischer D, Laczko E, Graf R, Clavien PA.

Hepatology. 2012 Jul;56(1):209-18. doi: 10.1002/hep.25626. Epub 2012 Jun 5.

PMID:
22290718
[PubMed - indexed for MEDLINE]
20.

Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice.

Fu ZD, Klaassen CD.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):137-46. doi: 10.1016/j.taap.2013.11.003. Epub 2013 Nov 13.

PMID:
24240088
[PubMed - indexed for MEDLINE]

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