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Results: 1 to 20 of 102

Similar articles for PubMed (Select 23947643)

1.

Structure-based β-secretase (BACE1) inhibitors.

Polgár T, Keseru GM.

Curr Pharm Des. 2014;20(20):3373-9. Review.

PMID:
23947643
2.

Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.

Brodney MA, Beck EM, Butler CR, Barreiro G, Johnson EF, Riddell D, Parris K, Nolan CE, Fan Y, Atchison K, Gonzales C, Robshaw AE, Doran SD, Bundesmann MW, Buzon L, Dutra J, Henegar K, LaChapelle E, Hou X, Rogers BN, Pandit J, Lira R, Martinez-Alsina L, Mikochik P, Murray JC, Ogilvie K, Price L, Sakya SM, Yu A, Zhang Y, O'Neill BT.

J Med Chem. 2015 Apr 9;58(7):3223-52. doi: 10.1021/acs.jmedchem.5b00191. Epub 2015 Apr 1.

PMID:
25781223
3.

Haloperidol inhibits Memapsin 2: innovation by docking simulation and in vitro assay.

Al-Nadaf AH, Taha MO, Aldal'in HK.

Pak J Pharm Sci. 2015 Jan;28(1):139-46.

PMID:
25553677
4.

β-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.

Park SH, Yang EJ, Kim SI, Song KS.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2945-8. doi: 10.1016/j.bmcl.2014.04.060. Epub 2014 Apr 24.

PMID:
24835197
5.

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.

Volgraf M, Chan L, Huestis MP, Purkey HE, Burkard M, Geck Do M, Harris J, Hunt KW, Liu X, Lyssikatos JP, Rana S, Thomas AA, Vigers GP, Siu M.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2477-80. doi: 10.1016/j.bmcl.2014.04.012. Epub 2014 Apr 13.

PMID:
24780121
6.

The evolution of amidine-based brain penetrant BACE1 inhibitors.

Oehlrich D, Prokopcova H, Gijsen HJ.

Bioorg Med Chem Lett. 2014 May 1;24(9):2033-45. doi: 10.1016/j.bmcl.2014.03.025. Epub 2014 Mar 20. Review.

7.

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF.

J Neurochem. 2014 Jul;130(1):4-28. doi: 10.1111/jnc.12715. Epub 2014 Apr 19. Review.

8.

Targeting the β secretase BACE1 for Alzheimer's disease therapy.

Yan R, Vassar R.

Lancet Neurol. 2014 Mar;13(3):319-29. doi: 10.1016/S1474-4422(13)70276-X. Epub 2014 Feb 17. Review.

9.

Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.

Werner M, Kuratli C, Martin RE, Hochstrasser R, Wechsler D, Enderle T, Alanine AI, Vogel H.

Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1704-8. doi: 10.1002/anie.201309301. Epub 2014 Jan 23.

PMID:
24458566
10.

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Hamada Y, Suzuki K, Nakanishi T, Sarma D, Ohta H, Yamaguchi R, Yamasaki M, Hidaka K, Ishiura S, Kiso Y.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):618-23. doi: 10.1016/j.bmcl.2013.12.007. Epub 2013 Dec 8.

PMID:
24360554
11.

N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides as BACE1 inhibitors: a patent evaluation of WO2013041499.

Dessolin J.

Expert Opin Ther Pat. 2014 Feb;24(2):239-42. doi: 10.1517/13543776.2014.859246. Epub 2013 Nov 13. Review.

PMID:
24219148
12.

A stereoselective approach to peptidomimetic BACE1 inhibitors.

Butini S, Gabellieri E, Brindisi M, Giovani S, Maramai S, Kshirsagar G, Guarino E, Brogi S, La Pietra V, Giustiniano M, Marinelli L, Novellino E, Campiani G, Cappelli A, Gemma S.

Eur J Med Chem. 2013;70:233-47. doi: 10.1016/j.ejmech.2013.09.056. Epub 2013 Oct 6.

PMID:
24158015
13.

Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.

Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S.

Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28.

PMID:
24051074
14.

Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.

Suzuki K, Hamada Y, Nguyen JT, Kiso Y.

Bioorg Med Chem. 2013 Nov 1;21(21):6665-73. doi: 10.1016/j.bmc.2013.08.016. Epub 2013 Aug 12.

PMID:
23993670
15.

The selective BACE1 inhibitor VIa reduces amyloid-β production in cell and mouse models of Alzheimer's disease.

Cheng X, Zhou Y, Gu W, Wu J, Nie A, Cheng J, Zhou J, Zhou W, Zhang Y.

J Alzheimers Dis. 2013;37(4):823-34. doi: 10.3233/JAD-130836.

PMID:
23948917
16.

The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.

Butini S, Brogi S, Novellino E, Campiani G, Ghosh AK, Brindisi M, Gemma S.

Curr Top Med Chem. 2013;13(15):1787-807. Review.

PMID:
23931442
17.

Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.

Devi L, Ohno M.

Transl Psychiatry. 2013 Jul 23;3:e284. doi: 10.1038/tp.2013.59.

18.

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

Fernández-Bachiller MI, Horatscheck A, Lisurek M, Rademann J.

ChemMedChem. 2013 Jul;8(7):1041-56. doi: 10.1002/cmdc.201300078. Epub 2013 Jun 11.

PMID:
23757181
19.

BACE1 inhibitors: a head group scan on a series of amides.

Woltering TJ, Wostl W, Hilpert H, Rogers-Evans M, Pinard E, Mayweg A, Göbel M, Banner DW, Benz J, Travagli M, Pollastrini M, Marconi G, Gabellieri E, Guba W, Mauser H, Andreini M, Jacobsen H, Power E, Narquizian R.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4239-43. doi: 10.1016/j.bmcl.2013.05.003. Epub 2013 May 18.

PMID:
23735744
20.
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