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Items: 1 to 20 of 110

1.

Possible role of inter-domain salt bridges in oligopeptidase B from Trypanosoma brucei: critical role of Glu172 of non-catalytic β-propeller domain in catalytic activity and Glu490 of catalytic domain in stability of OPB.

Fukumoto J, Ismail NI, Kubo M, Kinoshita K, Inoue M, Yuasa K, Nishimoto M, Matsuki H, Tsuji A.

J Biochem. 2013 Nov;154(5):465-73. doi: 10.1093/jb/mvt077. Epub 2013 Aug 13.

PMID:
23946505
2.

A critical role for highly conserved Glu(610) residue of oligopeptidase B from Trypanosoma brucei in thermal stability.

Mohd Ismail NI, Yuasa T, Yuasa K, Nambu Y, Nisimoto M, Goto M, Matsuki H, Inoue M, Nagahama M, Tsuji A.

J Biochem. 2010 Feb;147(2):201-11. doi: 10.1093/jb/mvp156. Epub 2009 Oct 9.

PMID:
19819899
3.

Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes.

Canning P, Rea D, Morty RE, Fülöp V.

PLoS One. 2013 Nov 12;8(11):e79349. doi: 10.1371/journal.pone.0079349. eCollection 2013.

4.

Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor.

McLuskey K, Paterson NG, Bland ND, Isaacs NW, Mottram JC.

J Biol Chem. 2010 Dec 10;285(50):39249-59. doi: 10.1074/jbc.M110.156679. Epub 2010 Oct 5.

5.

Trypanosoma brucei brucei oligopeptidase B null mutants display increased prolyl oligopeptidase-like activity.

Kangethe RT, Boulangé AF, Coustou V, Baltz T, Coetzer TH.

Mol Biochem Parasitol. 2012 Mar-Apr;182(1-2):7-16. doi: 10.1016/j.molbiopara.2011.11.007. Epub 2011 Nov 22.

PMID:
22123425
6.

Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases.

Morty RE, Lonsdale-Eccles JD, Morehead J, Caler EV, Mentele R, Auerswald EA, Coetzer TH, Andrews NW, Burleigh BA.

J Biol Chem. 1999 Sep 10;274(37):26149-56.

7.

Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.

Bastos IM, Grellier P, Martins NF, Cadavid-Restrepo G, de Souza-Ault MR, Augustyns K, Teixeira AR, Schrével J, Maigret B, da Silveira JF, Santana JM.

Biochem J. 2005 May 15;388(Pt 1):29-38.

8.

Proteases from Trypanosoma brucei brucei. Purification, characterisation and interactions with host regulatory molecules.

Troeberg L, Pike RN, Morty RE, Berry RK, Coetzer TH, Lonsdale-Eccles JD.

Eur J Biochem. 1996 Jun 15;238(3):728-36.

9.

Mechanistic insights into mode of actions of novel oligopeptidase B inhibitors for combating leishmaniasis.

Goyal S, Grover S, Dhanjal JK, Goyal M, Tyagi C, Chacko S, Grover A.

J Mol Model. 2014 Mar;20(3):2099. doi: 10.1007/s00894-014-2099-6. Epub 2014 Feb 25.

PMID:
24567150
10.

Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice.

Bastos IM, Motta FN, Charneau S, Santana JM, Dubost L, Augustyns K, Grellier P.

Microbes Infect. 2010 Jun;12(6):457-66. doi: 10.1016/j.micinf.2010.02.007. Epub 2010 Feb 24.

PMID:
20188209
11.

The prolyl oligopeptidase family.

Polgár L.

Cell Mol Life Sci. 2002 Feb;59(2):349-62. Review.

PMID:
11915948
12.

Glu88 in the non-catalytic domain of acylpeptide hydrolase plays dual roles: charge neutralization for enzymatic activity and formation of salt bridge for thermodynamic stability.

Yang G, Bai A, Gao L, Zhang Z, Zheng B, Feng Y.

Biochim Biophys Acta. 2009 Jan;1794(1):94-102. doi: 10.1016/j.bbapap.2008.09.007. Epub 2008 Oct 1.

PMID:
18930847
13.

Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding.

Szeltner Z, Rea D, Juhász T, Renner V, Fülöp V, Polgár L.

J Mol Biol. 2004 Jul 9;340(3):627-37.

PMID:
15210359
14.

Oligopeptidase B: a processing peptidase involved in pathogenesis.

Coetzer TH, Goldring JP, Huson LE.

Biochimie. 2008 Feb;90(2):336-44. Epub 2007 Nov 1. Review.

PMID:
18029266
15.

Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase.

Juhász T, Szeltner Z, Fülöp V, Polgár L.

J Mol Biol. 2005 Feb 25;346(3):907-17. Epub 2005 Jan 5.

PMID:
15713471
16.
18.

Mechanisms of intramolecular communication in a hyperthermophilic acylaminoacyl peptidase: a molecular dynamics investigation.

Papaleo E, Renzetti G, Tiberti M.

PLoS One. 2012;7(4):e35686. doi: 10.1371/journal.pone.0035686. Epub 2012 Apr 27.

19.

The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity.

Szeltner Z, Juhász T, Szamosi I, Rea D, Fülöp V, Módos K, Juliano L, Polgár L.

Biochim Biophys Acta. 2013 Jan;1834(1):98-111. doi: 10.1016/j.bbapap.2012.08.012. Epub 2012 Aug 19.

PMID:
22940581
20.

Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways.

Fuxreiter M, Magyar C, Juhász T, Szeltner Z, Polgár L, Simon I.

Proteins. 2005 Aug 15;60(3):504-12.

PMID:
15971204
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