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Testosterone delivered with a scaffold is as effective as bone morphologic protein-2 in promoting the repair of critical-size segmental defect of femoral bone in mice.

Cheng BH, Chu TM, Chang C, Kang HY, Huang KE.

PLoS One. 2013 Aug 5;8(8):e70234. doi: 10.1371/journal.pone.0070234. Print 2013.


Functional restoration of critically sized segmental defects with bone morphogenetic protein-2 and heparin treatment.

Johnson MR, Boerckel JD, Dupont KM, Guldberg RE.

Clin Orthop Relat Res. 2011 Nov;469(11):3111-7. doi: 10.1007/s11999-011-2012-x.


The effects of 3D bioactive glass scaffolds and BMP-2 on bone formation in rat femoral critical size defects and adjacent bones.

Liu WC, Robu IS, Patel R, Leu MC, Velez M, Chu TM.

Biomed Mater. 2014 Aug;9(4):045013. doi: 10.1088/1748-6041/9/4/045013. Epub 2014 Jul 25.


Improved healing of large segmental defects in the rat femur by reverse dynamization in the presence of bone morphogenetic protein-2.

Glatt V, Miller M, Ivkovic A, Liu F, Parry N, Griffin D, Vrahas M, Evans C.

J Bone Joint Surg Am. 2012 Nov 21;94(22):2063-73. doi: 10.2106/JBJS.K.01604.


Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration.

Chu TM, Sargent P, Warden SJ, Turner CH, Stewart RL.

Biomed Sci Instrum. 2006;42:42-7.


Local injection of lovastatin in biodegradable polyurethane scaffolds enhances bone regeneration in a critical-sized segmental defect in rat femora.

Yoshii T, Hafeman AE, Esparza JM, Okawa A, Gutierrez G, Guelcher SA.

J Tissue Eng Regen Med. 2014 Aug;8(8):589-95. doi: 10.1002/term.1547. Epub 2012 Jun 20.


Enhancement of BMP-2 induced bone regeneration by SDF-1α mediated stem cell recruitment.

Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Maetzig T, Goodman SB, Stiehler M.

Tissue Eng Part A. 2014 Feb;20(3-4):810-8. doi: 10.1089/ten.TEA.2013.0222. Epub 2013 Nov 12.


Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects.

Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J.

Clin Orthop Relat Res. 2014 Dec;472(12):4015-23. doi: 10.1007/s11999-014-3841-1. Epub 2014 Aug 7.


Segmental bone regeneration using rhBMP-2-loaded collagen/chitosan microspheres composite scaffold in a rabbit model.

Hou J, Wang J, Cao L, Qian X, Xing W, Lu J, Liu C.

Biomed Mater. 2012 Jun;7(3):035002. doi: 10.1088/1748-6041/7/3/035002. Epub 2012 Feb 23.


Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects.

Oest ME, Dupont KM, Kong HJ, Mooney DJ, Guldberg RE.

J Orthop Res. 2007 Jul;25(7):941-50.


Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds.

Lee SS, Huang BJ, Kaltz SR, Sur S, Newcomb CJ, Stock SR, Shah RN, Stupp SI.

Biomaterials. 2013 Jan;34(2):452-9. doi: 10.1016/j.biomaterials.2012.10.005. Epub 2012 Oct 23.


BMP-2 mRNA expression after endothelial progenitor cell therapy for fracture healing.

Li R, Nauth A, Gandhi R, Syed K, Schemitsch EH.

J Orthop Trauma. 2014;28 Suppl 1:S24-7. doi: 10.1097/BOT.0000000000000071.


Enhanced effects of BMP-binding peptide combined with recombinant human BMP-2 on the healing of a rodent segmental femoral defect.

Morishita Y, Naito M, Miyazaki M, He W, Wu G, Wei F, Sintuu C, Hymanson H, Brochmann EJ, Murray SS, Wang JC.

J Orthop Res. 2010 Feb;28(2):258-64. doi: 10.1002/jor.20970.


Enhanced healing of rabbit segmental radius defects with surface-coated calcium phosphate cement/bone morphogenetic protein-2 scaffolds.

Wu Y, Hou J, Yin M, Wang J, Liu C.

Mater Sci Eng C Mater Biol Appl. 2014 Nov;44:326-35. doi: 10.1016/j.msec.2014.08.020. Epub 2014 Aug 10.


Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release.

Brown KV, Li B, Guda T, Perrien DS, Guelcher SA, Wenke JC.

Tissue Eng Part A. 2011 Jul;17(13-14):1735-46. doi: 10.1089/ten.TEA.2010.0446. Epub 2011 Apr 3.


In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4.

Rundle CH, Miyakoshi N, Kasukawa Y, Chen ST, Sheng MH, Wergedal JE, Lau KH, Baylink DJ.

Bone. 2003 Jun;32(6):591-601.


Increasing vascularity to improve healing of a segmental defect of the rat femur.

Stewart R, Goldstein J, Eberhardt A, Chu GT, Gilbert S.

J Orthop Trauma. 2011 Aug;25(8):472-6. doi: 10.1097/BOT.0b013e31822588d8.


Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model.

Little DG, McDonald M, Bransford R, Godfrey CB, Amanat N.

J Bone Miner Res. 2005 Nov;20(11):2044-52. Epub 2005 Jul 18.


Healing of rat femoral segmental defect with bone morphogenetic protein-2: a dose response study.

Angle SR, Sena K, Sumner DR, Virkus WW, Virdi AS.

J Musculoskelet Neuronal Interact. 2012 Mar;12(1):28-37.


Bone regeneration using a bone morphogenetic protein-2 saturated slow-release gelatin hydrogel sheet: evaluation in a canine orbital floor fracture model.

Asamura S, Mochizuki Y, Yamamoto M, Tabata Y, Isogai N.

Ann Plast Surg. 2010 Apr;64(4):496-502. doi: 10.1097/SAP.0b013e31819b6c52.

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