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Results: 1 to 20 of 99

1.

Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes.

Shawi M, Chu TW, Martinez-Marignac V, Yu Y, Gryaznov SM, Johnston JB, Lees-Miller SP, Assouline SE, Autexier C, Aloyz R.

PLoS One. 2013 Jul 29;8(7):e70428. doi: 10.1371/journal.pone.0070428. Print 2013.

PMID:
23922990
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase.

Ting NS, Yu Y, Pohorelic B, Lees-Miller SP, Beattie TL.

Nucleic Acids Res. 2005 Apr 11;33(7):2090-8. Print 2005.

PMID:
15824061
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Human Ku70/80 associates physically with telomerase through interaction with hTERT.

Chai W, Ford LP, Lenertz L, Wright WE, Shay JW.

J Biol Chem. 2002 Dec 6;277(49):47242-7. Epub 2002 Oct 10.

PMID:
12377759
[PubMed - indexed for MEDLINE]
Free Article
4.

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.

Moussay E, Palissot V, Vallar L, Poirel HA, Wenner T, El Khoury V, Aouali N, Van Moer K, Leners B, Bernardin F, Muller A, Cornillet-Lefebvre P, Delmer A, Duhem C, Ries F, van Dyck E, Berchem G.

Mol Cancer. 2010 May 20;9:115. doi: 10.1186/1476-4598-9-115.

PMID:
20487546
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

Zenz T, Häbe S, Denzel T, Mohr J, Winkler D, Bühler A, Sarno A, Groner S, Mertens D, Busch R, Hallek M, Döhner H, Stilgenbauer S.

Blood. 2009 Sep 24;114(13):2589-97. doi: 10.1182/blood-2009-05-224071. Epub 2009 Jul 30.

PMID:
19643983
[PubMed - indexed for MEDLINE]
Free Article
6.

Telomerase antagonist imetelstat inhibits esophageal cancer cell growth and increases radiation-induced DNA breaks.

Wu X, Smavadati S, Nordfjäll K, Karlsson K, Qvarnström F, Simonsson M, Bergqvist M, Gryaznov S, Ekman S, Paulsson-Karlsson Y.

Biochim Biophys Acta. 2012 Dec;1823(12):2130-5. doi: 10.1016/j.bbamcr.2012.08.003. Epub 2012 Aug 11.

PMID:
22906540
[PubMed - indexed for MEDLINE]
Free Article
7.

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia.

Ferracin M, Zagatti B, Rizzotto L, Cavazzini F, Veronese A, Ciccone M, Saccenti E, Lupini L, Grilli A, De Angeli C, Negrini M, Cuneo A.

Mol Cancer. 2010 May 26;9:123. doi: 10.1186/1476-4598-9-123.

PMID:
20504344
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

17p Deletion is associated with resistance of B-cell chronic lymphocytic leukemia cells to in vitro fludarabine-induced apoptosis.

Turgut B, Vural O, Pala FS, Pamuk GE, Tabakcioğlu K, Demir M, Ongören S, Soysal T, Algüneş C.

Leuk Lymphoma. 2007 Feb;48(2):311-20.

PMID:
17325891
[PubMed - indexed for MEDLINE]
9.

DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.

Svirnovski AI, Serhiyenka TF, Kustanovich AM, Khlebko PV, Fedosenko VV, Taras IB, Bakun AV.

Exp Oncol. 2010 Dec;32(4):258-62.

PMID:
21270755
[PubMed - indexed for MEDLINE]
10.

The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines.

Joseph I, Tressler R, Bassett E, Harley C, Buseman CM, Pattamatta P, Wright WE, Shay JW, Go NF.

Cancer Res. 2010 Nov 15;70(22):9494-504. doi: 10.1158/0008-5472.CAN-10-0233. Epub 2010 Nov 9.

PMID:
21062983
[PubMed - indexed for MEDLINE]
Free Article
11.

Role of myeloid cell factor-1 (Mcl-1) in chronic lymphocytic leukemia.

Johnston JB, Paul JT, Neufeld NJ, Haney N, Kropp DM, Hu X, Cheang M, Gibson SB.

Leuk Lymphoma. 2004 Oct;45(10):2017-27.

PMID:
15370246
[PubMed - indexed for MEDLINE]
12.

Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells.

Dietrich S, Krämer OH, Hahn E, Schäfer C, Giese T, Hess M, Tretter T, Rieger M, Hüllein J, Zenz T, Ho AD, Dreger P, Luft T.

Clin Cancer Res. 2012 Jan 15;18(2):417-31. doi: 10.1158/1078-0432.CCR-11-1049. Epub 2011 Nov 9.

PMID:
22072733
[PubMed - indexed for MEDLINE]
Free Article
13.

Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response.

Rosenwald A, Chuang EY, Davis RE, Wiestner A, Alizadeh AA, Arthur DC, Mitchell JB, Marti GE, Fowler DH, Wilson WH, Staudt LM.

Blood. 2004 Sep 1;104(5):1428-34. Epub 2004 May 11.

PMID:
15138159
[PubMed - indexed for MEDLINE]
Free Article
14.

Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukemia.

Podhorecka M, Halicka D, Klimek P, Kowal M, Chocholska S, Dmoszynska A.

Ann Hematol. 2011 Feb;90(2):173-83. doi: 10.1007/s00277-010-1045-7. Epub 2010 Aug 17.

PMID:
20714724
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton.

Mender I, Senturk S, Ozgunes N, Akcali KC, Kletsas D, Gryaznov S, Can A, Shay JW, Dikmen ZG.

Int J Oncol. 2013 May;42(5):1709-15. doi: 10.3892/ijo.2013.1865. Epub 2013 Mar 27.

PMID:
23545855
[PubMed - indexed for MEDLINE]
16.

In vitro sensitivity of CLL cells to fludarabine may be modulated by the stimulation of Toll-like receptors.

Fonte E, Apollonio B, Scarfò L, Ranghetti P, Fazi C, Ghia P, Caligaris-Cappio F, Muzio M.

Clin Cancer Res. 2013 Jan 15;19(2):367-79. doi: 10.1158/1078-0432.CCR-12-1922. Epub 2012 Dec 5.

PMID:
23224401
[PubMed - indexed for MEDLINE]
Free Article
17.

Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal.

Moufarij MA, Sampath D, Keating MJ, Plunkett W.

Blood. 2006 Dec 15;108(13):4187-93. Epub 2006 Sep 5.

PMID:
16954499
[PubMed - indexed for MEDLINE]
Free PMC Article
18.
19.

Correlation of chemosensitivity to anticancer drugs and telomere length, telomerase activity and telomerase RNA expression in human ovarian cancer cells.

Kiyozuka Y, Yamamoto D, Yang J, Uemura Y, Senzaki H, Adachi S, Tsubura A.

Anticancer Res. 2000 Jan-Feb;20(1A):203-12.

PMID:
10769656
[PubMed - indexed for MEDLINE]
20.

Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine.

de la Fuente MT, Casanova B, Moyano JV, Garcia-Gila M, Sanz L, Garcia-Marco J, Silva A, Garcia-Pardo A.

J Leukoc Biol. 2002 Mar;71(3):495-502.

PMID:
11867687
[PubMed - indexed for MEDLINE]
Free Article

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