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Cell surface nucleolin is crucial in the activation of the CXCL12/CXCR4 signaling pathway.

Yang X, Xu Z, Li D, Cheng S, Fan K, Li C, Li A, Zhang J, Feng M.

Tumour Biol. 2014 Jan;35(1):333-8. doi: 10.1007/s13277-013-1044-0. Epub 2013 Aug 6.


Cell surface nucleolin interacts with CXCR4 receptor via the 212 c-terminal portion.

Niu H, Yang X, Xu Z, Du T, Wang R.

Tumour Biol. 2015 Feb;36(2):1099-104. doi: 10.1007/s13277-014-2734-y. Epub 2014 Oct 19.


Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells.

Heinrich EL, Lee W, Lu J, Lowy AM, Kim J.

J Transl Med. 2012 Apr 2;10:68. doi: 10.1186/1479-5876-10-68.


Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.

Chen G, Chen SM, Wang X, Ding XF, Ding J, Meng LH.

J Biol Chem. 2012 Apr 6;287(15):12132-41. doi: 10.1074/jbc.M111.302299. Epub 2012 Feb 15. Erratum in: J Biol Chem. 2012 Jun 1;287(23):19336.


LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways.

Wu M, Chen Q, Li D, Li X, Li X, Huang C, Tang Y, Zhou Y, Wang D, Tang K, Cao L, Shen S, Li G.

J Cell Biochem. 2008 Jan 1;103(1):245-55.


Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas.

Castellone MD, Guarino V, De Falco V, Carlomagno F, Basolo F, Faviana P, Kruhoffer M, Orntoft T, Russell JP, Rothstein JL, Fusco A, Santoro M, Melillo RM.

Oncogene. 2004 Aug 5;23(35):5958-67.


Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain.

Li R, Luo C, Mines M, Zhang J, Fan GH.

J Biol Chem. 2006 Dec 8;281(49):37616-27. Epub 2006 Oct 19. Erratum in: J Biol Chem. 2007 Apr 27;282(17):13140.


Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type.

Krust B, El Khoury D, Nondier I, Soundaramourty C, Hovanessian AG.

BMC Cancer. 2011 Aug 3;11:333. doi: 10.1186/1471-2407-11-333.


MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha.

Leone V, D'Angelo D, Rubio I, de Freitas PM, Federico A, Colamaio M, Pallante P, Medeiros-Neto G, Fusco A.

J Clin Endocrinol Metab. 2011 Sep;96(9):E1388-98. doi: 10.1210/jc.2011-0345. Epub 2011 Jul 13.


CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions.

Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S.

J Biol Chem. 2012 Nov 9;287(46):39115-24. doi: 10.1074/jbc.M112.409581. Epub 2012 Sep 20.


[Effect of chemokine CXCL12 and its receptor CXCR4 on proliferation, migration and invasion of epithelial ovarian cancer cells].

Jiang YP, Wu XH, Xing HY, DU XY.

Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):403-7. Chinese.


CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells.

Zhao HB, Tang CL, Hou YL, Xue LR, Li MQ, Du MR, Li DJ.

PLoS One. 2012;7(7):e38375. doi: 10.1371/journal.pone.0038375. Epub 2012 Jul 27.


Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways.

Huang CY, Lee CY, Chen MY, Yang WH, Chen YH, Chang CH, Hsu HC, Fong YC, Tang CH.

J Cell Physiol. 2009 Oct;221(1):204-12. doi: 10.1002/jcp.21846.


Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-kappaB-dependent pathway in human lung cancer cells.

Huang YC, Hsiao YC, Chen YJ, Wei YY, Lai TH, Tang CH.

Biochem Pharmacol. 2007 Dec 15;74(12):1702-12. Epub 2007 Aug 25.


Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12.

McCaig AM, Cosimo E, Leach MT, Michie AM.

PLoS One. 2012;7(11):e48929. doi: 10.1371/journal.pone.0048929. Epub 2012 Nov 2.


Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway.

Asano S, Kitatani K, Taniguchi M, Hashimoto M, Zama K, Mitsutake S, Igarashi Y, Takeya H, Kigawa J, Hayashi A, Umehara H, Okazaki T.

Mol Cell Biol. 2012 Aug;32(16):3242-52. doi: 10.1128/MCB.00121-12. Epub 2012 Jun 11.


Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.

Yuan L, Zhang H, Liu J, Rubin JB, Cho YJ, Shu HK, Schniederjan M, MacDonald TJ.

Mol Cancer. 2013 Mar 5;12:18. doi: 10.1186/1476-4598-12-18.


Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells.

Reyes-Reyes EM, Akiyama SK.

Exp Cell Res. 2008 Jul 1;314(11-12):2212-23. doi: 10.1016/j.yexcr.2008.03.016. Epub 2008 Apr 7.


Nucleolin promotes TGF-β signaling initiation via TGF-β receptor I in glioblastoma.

Lv S, Zhang J, Han M, Wang W, Zhang Y, Zhuang D, Shi R, Bian R, Yao C.

J Mol Neurosci. 2015 Jan;55(1):1-6. doi: 10.1007/s12031-014-0292-9. Epub 2014 Apr 1.

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