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Results: 1 to 20 of 98

1.

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J.

Elife. 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813.

PMID:
23908768
[PubMed - in process]
Free PMC Article
2.

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.

Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.

Mol Cell Biol. 2005 Jun;25(11):4426-41.

PMID:
15899849
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.

Zahedi B, Goo HJ, Beaulieu N, Tazmini G, Kay RJ, Cornell RB.

J Biol Chem. 2011 Apr 8;286(14):12712-23. doi: 10.1074/jbc.M110.189605. Epub 2011 Feb 1.

PMID:
21285350
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain.

Tazmini G, Beaulieu N, Woo A, Zahedi B, Goulding RE, Kay RJ.

Biochim Biophys Acta. 2009 Mar;1793(3):447-61. doi: 10.1016/j.bbamcr.2008.12.019. Epub 2009 Jan 3.

PMID:
19168098
[PubMed - indexed for MEDLINE]
Free Article
5.

G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.

Kremer KN, Kumar A, Hedin KE.

J Immunol. 2011 Sep 15;187(6):3177-85. doi: 10.4049/jimmunol.1100206. Epub 2011 Aug 19.

PMID:
21856938
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

Priatel JJ, Teh SJ, Dower NA, Stone JC, Teh HS.

Immunity. 2002 Nov;17(5):617-27.

PMID:
12433368
[PubMed - indexed for MEDLINE]
7.

Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.

Beaulieu N, Zahedi B, Goulding RE, Tazmini G, Anthony KV, Omeis SL, de Jong DR, Kay RJ.

Mol Biol Cell. 2007 Aug;18(8):3156-68. Epub 2007 Jun 13.

PMID:
17567957
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP.

Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020.

PMID:
24336796
[PubMed - in process]
Free PMC Article
9.

RasGRP1 is required for human NK cell function.

Lee SH, Yun S, Lee J, Kim MJ, Piao ZH, Jeong M, Chung JW, Kim TD, Yoon SR, Greenberg PD, Choi I.

J Immunol. 2009 Dec 15;183(12):7931-8. doi: 10.4049/jimmunol.0902012. Epub .

PMID:
19933860
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

Stone JC.

Genes Cancer. 2011 Mar;2(3):320-34. doi: 10.1177/1947601911408082.

PMID:
21779502
[PubMed]
Free PMC Article
11.

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3305-10. doi: 10.1073/pnas.1113512109. Epub 2012 Feb 13.

PMID:
22331897
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

Carrasco S, Merida I.

Mol Biol Cell. 2004 Jun;15(6):2932-42. Epub 2004 Apr 2.

PMID:
15064353
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.

Hall BE, Yang SS, Boriack-Sjodin PA, Kuriyan J, Bar-Sagi D.

J Biol Chem. 2001 Jul 20;276(29):27629-37. Epub 2001 May 1.

PMID:
11333268
[PubMed - indexed for MEDLINE]
Free Article
14.

RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

Priatel JJ, Chen X, Dhanji S, Abraham N, Teh HS.

J Immunol. 2006 Aug 1;177(3):1470-80.

PMID:
16849453
[PubMed - indexed for MEDLINE]
Free Article
15.

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.

Coughlin JJ, Stang SL, Dower NA, Stone JC.

J Immunol. 2005 Dec 1;175(11):7179-84.

PMID:
16301621
[PubMed - indexed for MEDLINE]
Free Article
16.

New insights into the mechanisms of SOS activation.

Quilliam LA.

Sci STKE. 2007 Nov 27;2007(414):pe67.

PMID:
18042941
[PubMed - indexed for MEDLINE]
17.

SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.

Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T.

Mol Immunol. 2008 Jan;45(2):510-22. Epub 2007 Jul 20.

PMID:
17658605
[PubMed - indexed for MEDLINE]
18.

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.

Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A.

Mol Cell Biol. 2007 Apr;27(7):2732-45. Epub 2007 Feb 5.

PMID:
17283063
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice.

Chen X, Priatel JJ, Chow MT, Teh HS.

J Immunol. 2008 May 1;180(9):5973-82.

PMID:
18424717
[PubMed - indexed for MEDLINE]
Free Article
20.

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.

Bivona TG, Pérez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR.

Nature. 2003 Aug 7;424(6949):694-8. Epub 2003 Jun 29.

PMID:
12845332
[PubMed - indexed for MEDLINE]
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