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Results: 1 to 20 of 139

Similar articles for PubMed (Select 23907250)

1.

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.

Dimitrov M, Alattia JR, Lemmin T, Lehal R, Fligier A, Houacine J, Hussain I, Radtke F, Dal Peraro M, Beher D, Fraering PC.

Nat Commun. 2013;4:2246. doi: 10.1038/ncomms3246.

PMID:
23907250
2.

Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.

Suárez-Calvet M, Belbin O, Pera M, Badiola N, Magrané J, Guardia-Laguarta C, Muñoz L, Colom-Cadena M, Clarimón J, Lleó A.

J Neurochem. 2014 Jan;128(2):330-9. doi: 10.1111/jnc.12466. Epub 2013 Oct 24.

PMID:
24117942
3.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

PMID:
15992373
4.

Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.

Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K.

Am J Geriatr Psychiatry. 2013 May;21(5):474-83. doi: 10.1016/j.jagp.2013.02.009.

5.

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.

Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE.

J Biol Chem. 2011 Nov 18;286(46):39804-12. doi: 10.1074/jbc.M111.274696. Epub 2011 Aug 25.

6.

Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates.

Mitani Y, Akashiba H, Saita K, Yarimizu J, Uchino H, Okabe M, Asai M, Yamasaki S, Nozawa T, Ishikawa N, Shitaka Y, Ni K, Matsuoka N.

Neuropharmacology. 2014 Apr;79:412-9. doi: 10.1016/j.neuropharm.2013.12.013. Epub 2013 Dec 25.

PMID:
24373902
7.

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J.

Exp Cell Res. 2003 Jul 1;287(1):1-9.

PMID:
12799176
8.

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Heilig EA, Xia W, Shen J, Kelleher RJ 3rd.

J Biol Chem. 2010 Jul 16;285(29):22350-9. doi: 10.1074/jbc.M110.116962. Epub 2010 May 11.

9.
10.

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.

J Biol Chem. 2002 Sep 27;277(39):36521-6. Epub 2002 Jul 15.

11.

Mechanism of intramembrane cleavage of alcadeins by γ-secretase.

Piao Y, Kimura A, Urano S, Saito Y, Taru H, Yamamoto T, Hata S, Suzuki T.

PLoS One. 2013 Apr 26;8(4):e62431. doi: 10.1371/journal.pone.0062431. Print 2013.

12.

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.

Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2.

13.

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8025-30. Epub 2002 Jun 4.

14.

Mutations in APP have independent effects on Abeta and CTFgamma generation.

Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM.

Neurobiol Dis. 2004 Nov;17(2):205-18.

PMID:
15474359
15.

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H.

J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27.

16.

γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.

Nakayama K, Nagase H, Koh CS, Ohkawara T.

Cell Mol Neurobiol. 2011 Aug;31(6):887-900. doi: 10.1007/s10571-011-9688-z. Epub 2011 Apr 23. Review.

PMID:
21516353
17.

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.

Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A.

BMC Neurosci. 2008 Jan 30;9:17. doi: 10.1186/1471-2202-9-17.

18.

Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.

Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M.

Biochemistry. 2013 Jun 4;52(22):3899-912. doi: 10.1021/bi400138p. Epub 2013 May 21.

PMID:
23663107
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