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Results: 1 to 20 of 90

1.

Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2.

Roy R, Usha V, Kermani A, Scott DJ, Hyde EI, Besra GS, Alderwick LJ, Fütterer K.

ACS Chem Biol. 2013 Oct 18;8(10):2245-55. doi: 10.1021/cb400508k. Epub 2013 Aug 13.

PMID:
23901909
[PubMed - in process]
Free PMC Article
2.

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.

Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR Jr.

Nat Chem Biol. 2010 May;6(5):376-84. doi: 10.1038/nchembio.340. Epub 2010 Mar 21.

PMID:
20305657
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Flux through trehalose synthase flows from trehalose to the alpha anomer of maltose in mycobacteria.

Miah F, Koliwer-Brandl H, Rejzek M, Field RA, Kalscheuer R, Bornemann S.

Chem Biol. 2013 Apr 18;20(4):487-93. doi: 10.1016/j.chembiol.2013.02.014.

PMID:
23601637
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Unexpected and widespread connections between bacterial glycogen and trehalose metabolism.

Chandra G, Chater KF, Bornemann S.

Microbiology. 2011 Jun;157(Pt 6):1565-72. doi: 10.1099/mic.0.044263-0. Epub 2011 Apr 7. Review.

PMID:
21474533
[PubMed - indexed for MEDLINE]
Free Article
5.

Trehalose synthase converts glycogen to trehalose.

Pan YT, Carroll JD, Asano N, Pastuszak I, Edavana VK, Elbein AD.

FEBS J. 2008 Jul;275(13):3408-20. doi: 10.1111/j.1742-4658.2008.06491.x. Epub 2008 May 23.

PMID:
18505459
[PubMed - indexed for MEDLINE]
6.

α-Glucan pathway as a novel Mtb drug target: structural insights and cues for polypharmcological targeting of GlgB and GlgE.

Agrawal P, Gupta P, Swaminathan K, Parkesh R.

Curr Med Chem. 2014;21(35):4074-84.

PMID:
25174919
[PubMed - in process]
7.

Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme.

Pan YT, Koroth Edavana V, Jourdian WJ, Edmondson R, Carroll JD, Pastuszak I, Elbein AD.

Eur J Biochem. 2004 Nov;271(21):4259-69.

PMID:
15511231
[PubMed - indexed for MEDLINE]
Free Article
8.

Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds α-maltose 1-phosphate and forms a maltosyl-enzyme intermediate.

Syson K, Stevenson CE, Rashid AM, Saalbach G, Tang M, Tuukkanen A, Svergun DI, Withers SG, Lawson DM, Bornemann S.

Biochemistry. 2014 Apr 22;53(15):2494-504. doi: 10.1021/bi500183c. Epub 2014 Apr 11.

PMID:
24689960
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Three pathways for trehalose biosynthesis in mycobacteria.

De Smet KA, Weston A, Brown IN, Young DB, Robertson BD.

Microbiology. 2000 Jan;146 ( Pt 1):199-208.

PMID:
10658666
[PubMed - indexed for MEDLINE]
Free Article
10.
11.

Last step in the conversion of trehalose to glycogen: a mycobacterial enzyme that transfers maltose from maltose 1-phosphate to glycogen.

Elbein AD, Pastuszak I, Tackett AJ, Wilson T, Pan YT.

J Biol Chem. 2010 Mar 26;285(13):9803-12. doi: 10.1074/jbc.M109.033944. Epub 2010 Jan 29.

PMID:
20118231
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgE.

Veleti SK, Lindenberger JJ, Thanna S, Ronning DR, Sucheck SJ.

J Org Chem. 2014 Oct 17;79(20):9444-50. doi: 10.1021/jo501481r. Epub 2014 Aug 26.

PMID:
25137149
[PubMed - in process]
13.

New insights on trehalose: a multifunctional molecule.

Elbein AD, Pan YT, Pastuszak I, Carroll D.

Glycobiology. 2003 Apr;13(4):17R-27R. Epub 2003 Jan 22. Review.

PMID:
12626396
[PubMed - indexed for MEDLINE]
Free Article
14.

Structure of Streptomyces maltosyltransferase GlgE, a homologue of a genetically validated anti-tuberculosis target.

Syson K, Stevenson CE, Rejzek M, Fairhurst SA, Nair A, Bruton CJ, Field RA, Chater KF, Lawson DM, Bornemann S.

J Biol Chem. 2011 Nov 4;286(44):38298-310. doi: 10.1074/jbc.M111.279315. Epub 2011 Sep 13.

PMID:
21914799
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Three pathways for trehalose metabolism in Corynebacterium glutamicum ATCC13032 and their significance in response to osmotic stress.

Wolf A, Krämer R, Morbach S.

Mol Microbiol. 2003 Aug;49(4):1119-34.

PMID:
12890033
[PubMed - indexed for MEDLINE]
16.

Redox biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide.

Garg S, Alam MS, Bajpai R, Kishan KR, Agrawal P.

BMC Biochem. 2009 Jan 5;10:1. doi: 10.1186/1471-2091-10-1.

PMID:
19121228
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Trehalose accumulation in mutants of Saccharomyces cerevisiae deleted in the UDPG-dependent trehalose synthase-phosphatase complex.

Ferreira JC, Thevelein JM, Hohmann S, Paschoalin VM, Trugo LC, Panek AD.

Biochim Biophys Acta. 1997 Apr 17;1335(1-2):40-50.

PMID:
9133641
[PubMed - indexed for MEDLINE]
18.

Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response.

Cardoso FS, Castro RF, Borges N, Santos H.

Microbiology. 2007 Jan;153(Pt 1):270-80.

PMID:
17185556
[PubMed - indexed for MEDLINE]
Free Article
19.

Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis.

Zhang R, Pan YT, He S, Lam M, Brayer GD, Elbein AD, Withers SG.

J Biol Chem. 2011 Oct 14;286(41):35601-9. doi: 10.1074/jbc.M111.280362. Epub 2011 Aug 12.

PMID:
21840994
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The significance of GlgE as a new target for tuberculosis.

Kalscheuer R, Jacobs WR Jr.

Drug News Perspect. 2010 Dec;23(10):619-24. doi: 10.1358/dnp.2010.23.10.1534855.

PMID:
21180647
[PubMed - indexed for MEDLINE]

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