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Results: 1 to 20 of 106

1.

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.

Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, Chang G.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13386-91. doi: 10.1073/pnas.1309275110. Epub 2013 Jul 30.

PMID:
23901103
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The flexibility of P-glycoprotein for its poly-specific drug binding from molecular dynamics simulations.

Liu M, Hou T, Feng Z, Li Y.

J Biomol Struct Dyn. 2013;31(6):612-29. doi: 10.1080/07391102.2012.706079. Epub 2012 Aug 13.

PMID:
22888853
[PubMed - indexed for MEDLINE]
3.

Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2.

Ritchie TK, Kwon H, Atkins WM.

J Biol Chem. 2011 Nov 11;286(45):39489-96. doi: 10.1074/jbc.M111.284554. Epub 2011 Sep 21.

PMID:
21937435
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans.

Jin MS, Oldham ML, Zhang Q, Chen J.

Nature. 2012 Oct 25;490(7421):566-9. doi: 10.1038/nature11448. Epub 2012 Sep 23.

PMID:
23000902
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Antibody C219 recognizes an alpha-helical epitope on P-glycoprotein.

van Den Elsen JM, Kuntz DA, Hoedemaeker FJ, Rose DR.

Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13679-84.

PMID:
10570132
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein.

Kimura Y, Matsuo M, Takahashi K, Saeki T, Kioka N, Amachi T, Ueda K.

Curr Drug Metab. 2004 Feb;5(1):1-10. Review.

PMID:
14965247
[PubMed - indexed for MEDLINE]
7.

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G.

Science. 2009 Mar 27;323(5922):1718-22. doi: 10.1126/science.1168750.

PMID:
19325113
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach.

Pleban K, Kopp S, Csaszar E, Peer M, Hrebicek T, Rizzi A, Ecker GF, Chiba P.

Mol Pharmacol. 2005 Feb;67(2):365-74. Epub 2004 Oct 27.

PMID:
15509712
[PubMed - indexed for MEDLINE]
Free Article
10.

P glycoprotein and the mechanism of multidrug resistance.

Váradi A, Szakács G, Bakos E, Sarkadi B.

Novartis Found Symp. 2002;243:54-65; discussion 65-8, 180-5. Review.

PMID:
11990782
[PubMed - indexed for MEDLINE]
11.

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.

Kodan A, Yamaguchi T, Nakatsu T, Sakiyama K, Hipolito CJ, Fujioka A, Hirokane R, Ikeguchi K, Watanabe B, Hiratake J, Kimura Y, Suga H, Ueda K, Kato H.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4049-54. doi: 10.1073/pnas.1321562111. Epub 2014 Mar 3.

PMID:
24591620
[PubMed - indexed for MEDLINE]
12.

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle.

Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, Higgins CF.

EMBO J. 2001 Oct 15;20(20):5615-25.

PMID:
11598005
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Functional role of the linker region in purified human P-glycoprotein.

Sato T, Kodan A, Kimura Y, Ueda K, Nakatsu T, Kato H.

FEBS J. 2009 Jul;276(13):3504-16. doi: 10.1111/j.1742-4658.2009.07072.x. Epub 2009 May 21.

PMID:
19490125
[PubMed - indexed for MEDLINE]
14.

On the origin of large flexibility of P-glycoprotein in the inward-facing state.

Wen PC, Verhalen B, Wilkens S, Mchaourab HS, Tajkhorshid E.

J Biol Chem. 2013 Jun 28;288(26):19211-20. doi: 10.1074/jbc.M113.450114. Epub 2013 May 8.

PMID:
23658020
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein.

Martin C, Higgins CF, Callaghan R.

Biochemistry. 2001 Dec 25;40(51):15733-42.

PMID:
11747450
[PubMed - indexed for MEDLINE]
16.

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

Lawson J, O'Mara ML, Kerr ID.

Biochim Biophys Acta. 2008 Feb;1778(2):376-91. Epub 2007 Nov 1. Review.

PMID:
18035039
[PubMed - indexed for MEDLINE]
Free Article
17.

Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein.

Bikadi Z, Hazai I, Malik D, Jemnitz K, Veres Z, Hari P, Ni Z, Loo TW, Clarke DM, Hazai E, Mao Q.

PLoS One. 2011;6(10):e25815. doi: 10.1371/journal.pone.0025815. Epub 2011 Oct 4.

PMID:
21991360
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.

Shukla S, Robey RW, Bates SE, Ambudkar SV.

Drug Metab Dispos. 2009 Feb;37(2):359-65. doi: 10.1124/dmd.108.024612. Epub 2008 Oct 29.

PMID:
18971320
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Molecular models of human P-glycoprotein in two different catalytic states.

Becker JP, Depret G, Van Bambeke F, Tulkens PM, Prévost M.

BMC Struct Biol. 2009 Jan 22;9:3. doi: 10.1186/1472-6807-9-3.

PMID:
19159494
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.

Breier A, Barancík M, Sulová Z, Uhrík B.

Curr Cancer Drug Targets. 2005 Sep;5(6):457-68. Review.

PMID:
16178819
[PubMed - indexed for MEDLINE]

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