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Results: 1 to 20 of 117

1.

Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation.

Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W.

Pharm Res. 2013 Sep;30(9):2199-208. doi: 10.1007/s11095-013-1101-9. Epub 2013 Jul 30.

PMID:
23896737
[PubMed - indexed for MEDLINE]
2.

Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.

Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O.

Br J Pharmacol. 2012 Mar;165(5):1595-608. doi: 10.1111/j.1476-5381.2011.01665.x.

PMID:
21913896
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.

Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.

Antimicrob Agents Chemother. 2013 Mar;57(3):1332-8. doi: 10.1128/AAC.01900-12. Epub 2012 Dec 28.

PMID:
23274663
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.

Roth A, Looser R, Kaufmann M, Meyer UA.

Pharmacogenet Genomics. 2008 Apr;18(4):325-37. doi: 10.1097/FPC.0b013e3282f706e0.

PMID:
18334917
[PubMed - indexed for MEDLINE]
5.

Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.

Li L, Hassan HE, Tolson AH, Ferguson SS, Eddington ND, Wang H.

J Pharmacol Exp Ther. 2010 Dec;335(3):562-71. doi: 10.1124/jpet.110.173187. Epub 2010 Sep 9.

PMID:
20829393
[PubMed - indexed for MEDLINE]
Free PMC Article
6.
7.

Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).

Anderson LE, Dring AM, Hamel LD, Stoner MA.

Toxicol Lett. 2011 Apr 25;202(2):148-54. doi: 10.1016/j.toxlet.2011.02.004. Epub 2011 Feb 18.

PMID:
21315811
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.

Park YJ, Lee EK, Lee YK, Park do J, Jang HC, Moore DD.

Toxicol Appl Pharmacol. 2012 Sep 1;263(2):131-7. doi: 10.1016/j.taap.2012.03.017. Epub 2012 Apr 3.

PMID:
22503787
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.

PMID:
17392393
[PubMed - indexed for MEDLINE]
Free Article
10.

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL.

J Biol Chem. 2003 Apr 18;278(16):14146-52. Epub 2003 Feb 5.

PMID:
12571232
[PubMed - indexed for MEDLINE]
Free Article
11.

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E.

J Biol Chem. 2004 Jul 9;279(28):29295-301. Epub 2004 Apr 28.

PMID:
15123723
[PubMed - indexed for MEDLINE]
Free Article
12.

The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.

Wang D, Li L, Fuhrman J, Ferguson S, Wang H.

Pharm Res. 2011 Aug;28(8):2034-44. doi: 10.1007/s11095-011-0429-2. Epub 2011 Apr 13.

PMID:
21487929
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.

Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):335-43. doi: 10.1016/j.taap.2010.03.017. Epub 2010 Mar 31.

PMID:
20361990
[PubMed - indexed for MEDLINE]
14.

Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.

Dvorák Z, Maurel P, Vilarem MJ, Ulrichová J, Modrianský M.

Cell Biol Toxicol. 2007 Mar;23(2):63-73. Epub 2006 Sep 10. Erratum in: Cell Biol Toxicol. 2007 Mar;23(2):141.

PMID:
16964586
[PubMed - indexed for MEDLINE]
15.

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.

J Biol Chem. 2002 Jan 25;277(4):2908-15. Epub 2001 Nov 12.

PMID:
11706036
[PubMed - indexed for MEDLINE]
Free Article
16.

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.

Krausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P.

Biochem Pharmacol. 2011 Dec 1;82(11):1771-80. doi: 10.1016/j.bcp.2011.08.023. Epub 2011 Sep 6.

PMID:
21920351
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.

Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S.

Mol Endocrinol. 2008 Apr;22(4):838-57. Epub 2007 Dec 20.

PMID:
18096694
[PubMed - indexed for MEDLINE]
18.

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.

Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM.

Genes Dev. 2000 Dec 1;14(23):3014-23.

PMID:
11114890
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.

Shenoy SD, Spencer TA, Mercer-Haines NA, Alipour M, Gargano MD, Runge-Morris M, Kocarek TA.

Drug Metab Dispos. 2004 Jan;32(1):66-71.

PMID:
14709622
[PubMed - indexed for MEDLINE]
Free Article
20.

The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.

Ding X, Lichti K, Staudinger JL.

Toxicol Sci. 2006 Jun;91(2):448-55. Epub 2006 Mar 17.

PMID:
16547076
[PubMed - indexed for MEDLINE]
Free PMC Article

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