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Items: 1 to 20 of 196

1.

Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.

Niu Y, Wu Z, Shen Q, Song J, Luo Q, You H, Shi G, Qin W.

Dig Liver Dis. 2013 Dec;45(12):1041-8. doi: 10.1016/j.dld.2013.06.004. Epub 2013 Jul 26.

PMID:
23891548
2.

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.

Wang YM, Lin W, Chai SC, Wu J, Ong SS, Schuetz EG, Chen T.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):96-107. doi: 10.1016/j.taap.2013.05.014. Epub 2013 May 22.

3.

Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.

Pang R, Lee TK, Poon RT, Fan ST, Wong KB, Kwong YL, Tse E.

Gastroenterology. 2007 Mar;132(3):1088-103. Epub 2006 Dec 19.

PMID:
17383430
5.

Hepatitis B virus X protein inhibits tumor suppressor miR-205 through inducing hypermethylation of miR-205 promoter to enhance carcinogenesis.

Zhang T, Zhang J, Cui M, Liu F, You X, Du Y, Gao Y, Zhang S, Lu Z, Ye L, Zhang X.

Neoplasia. 2013 Nov;15(11):1282-91.

6.
7.

Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP.

Zhang W, Lu Z, Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L, Zhang X.

Mol Cancer. 2014 May 28;13:128. doi: 10.1186/1476-4598-13-128.

8.

Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.

Vrzal R, Kubesova K, Pavek P, Dvorak Z.

Toxicol Lett. 2010 Mar 15;193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. Epub 2010 Jan 18.

PMID:
20080160
9.

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A by praeruptorin A isolated from the herbal medicine Peucedanum praeruptorum.

Huang L, Bi HC, Li YH, Zhang JQ, Kuang SY, Zhang L, Wang YT, Huang M.

Planta Med. 2013 Nov;79(16):1509-15. doi: 10.1055/s-0033-1350795. Epub 2013 Sep 13.

PMID:
24037590
10.

Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation.

Sivertsson L, Edebert I, Palmertz MP, Ingelman-Sundberg M, Neve EP.

Mol Pharmacol. 2013 Mar;83(3):659-70. doi: 10.1124/mol.112.082305. Epub 2012 Dec 21.

11.

Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma.

Xia L, Huang W, Tian D, Zhu H, Zhang Y, Hu H, Fan D, Nie Y, Wu K.

J Hepatol. 2012 Sep;57(3):600-12. doi: 10.1016/j.jhep.2012.04.020. Epub 2012 May 18.

PMID:
22613004
12.

Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma.

Na TY, Shin YK, Roh KJ, Kang SA, Hong I, Oh SJ, Seong JK, Park CK, Choi YL, Lee MO.

Hepatology. 2009 Apr;49(4):1122-31. doi: 10.1002/hep.22740.

PMID:
19105208
13.
14.

Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells.

Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Wang Y, Yang X, Ye L, Zhang X.

Hepatology. 2012 Dec;56(6):2051-9. doi: 10.1002/hep.25899. Epub 2012 Nov 13.

PMID:
22707013
15.

Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis.

Yu Z, Gao YQ, Feng H, Lee YY, Li MS, Tian Y, Go MY, Yu DY, Cheung YS, Lai PB, Yu J, Wong VW, Sung JJ, Chan HL, Cheng AS.

Gut. 2014 Nov;63(11):1793-804. doi: 10.1136/gutjnl-2013-305584. Epub 2014 Jan 17.

PMID:
24440987
16.

Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss).

Wassmur B, Gräns J, Kling P, Celander MC.

Aquat Toxicol. 2010 Oct 1;100(1):91-100. doi: 10.1016/j.aquatox.2010.07.013. Epub 2010 Jul 17.

PMID:
20719396
17.

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.

Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ.

Drug Metab Dispos. 2008 Dec;36(12):2506-12. doi: 10.1124/dmd.108.022723. Epub 2008 Sep 17.

18.

Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.

Watanabe K, Sakurai K, Tsuchiya Y, Yamazoe Y, Yoshinari K.

Biochem Pharmacol. 2013 Aug 1;86(3):428-36. doi: 10.1016/j.bcp.2013.05.016. Epub 2013 May 31.

PMID:
23732298
19.

Hepatitis B virus X gene and hepatocarcinogenesis.

Ng SA, Lee C.

J Gastroenterol. 2011 Aug;46(8):974-90. doi: 10.1007/s00535-011-0415-9. Epub 2011 Jun 8. Review.

PMID:
21647825
20.

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.

Luckert C, Ehlers A, Buhrke T, Seidel A, Lampen A, Hessel S.

Toxicol Lett. 2013 Oct 24;222(2):180-8. doi: 10.1016/j.toxlet.2013.06.243. Epub 2013 Jul 8.

PMID:
23845848
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