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Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.

Hagen KR, Zeng X, Lee MY, Tucker Kahn S, Harrison Pitner MK, Zaky SS, Liu Y, O'Regan RM, Deng X, Saavedra HI.

Cell Div. 2013 Jul 25;8(1):10. doi: 10.1186/1747-1028-8-10.


Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin.

Vanderlaag KE, Hudak S, Bald L, Fayadat-Dilman L, Sathe M, Grein J, Janatpour MJ.

Breast Cancer Res. 2010;12(3):R32. doi: 10.1186/bcr2586. Epub 2010 Jun 4.


Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells.

Sun Y, Li YX, Wu HJ, Wu SH, Wang YA, Luo DZ, Liao DJ.

J Cancer. 2011 Jan 8;2:36-51.


Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells.

Sweeney KJ, Sarcevic B, Sutherland RL, Musgrove EA.

Oncogene. 1997 Mar 20;14(11):1329-40.


Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.

Sweeney KJ, Swarbrick A, Sutherland RL, Musgrove EA.

Oncogene. 1998 Jun 4;16(22):2865-78.


Targeting the AKT/GSK3β/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy.

Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M.

Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):540-8. doi: 10.1016/j.ijrobp.2010.12.065. Epub 2011 Mar 11.


Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis.

Tsai SL, Suk FM, Wang CI, Liu DZ, Hou WC, Lin PJ, Hung LF, Liang YC.

Biochem Pharmacol. 2007 Dec 3;74(11):1575-86. Epub 2007 Aug 11.


Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells.

Kang J, Sergio CM, Sutherland RL, Musgrove EA.

BMC Cancer. 2014 Jan 20;14:32. doi: 10.1186/1471-2407-14-32.


COX-2 promotes breast cancer cell radioresistance via p38/MAPK-mediated cellular anti-apoptosis and invasiveness.

Lin F, Luo J, Gao W, Wu J, Shao Z, Wang Z, Meng J, Ou Z, Yang G.

Tumour Biol. 2013 Oct;34(5):2817-26. doi: 10.1007/s13277-013-0840-x. Epub 2013 Jun 15.


Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ.

Cancer Res. 1996 Jul 1;56(13):2973-8.


CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage.

Gogolin S, Ehemann V, Becker G, Brueckner LM, Dreidax D, Bannert S, Nolte I, Savelyeva L, Bell E, Westermann F.

Cell Cycle. 2013 Apr 1;12(7):1091-104. doi: 10.4161/cc.24091. Epub 2013 Mar 5.


Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line.

Hochhauser D, Schnieders B, Ercikan-Abali E, Gorlick R, Muise-Helmericks R, Li WW, Fan J, Banerjee D, Bertino JR.

J Natl Cancer Inst. 1996 Sep 18;88(18):1269-75.


Induction of Cell Cycle Arrest and Apoptosis by Physcion, an Anthraquinone Isolated From Rhubarb (Rhizomes of Rheum tanguticum), in MDA-MB-231 Human Breast Cancer Cells.

Hong JY, Chung HJ, Bae SY, Trung TN, Bae K, Lee SK.

J Cancer Prev. 2014 Dec;19(4):273-8. doi: 10.15430/JCP.2014.19.4.273.


Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation.

Reed MF, Liu VF, Ladha MH, Ando K, Griffin JD, Weaver DT, Ewen ME.

Oncogene. 1998 Dec 10;17(23):2961-71.


PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro.

Finn RS, Dering J, Conklin D, Kalous O, Cohen DJ, Desai AJ, Ginther C, Atefi M, Chen I, Fowst C, Los G, Slamon DJ.

Breast Cancer Res. 2009;11(5):R77. doi: 10.1186/bcr2419.


Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.

Warenius HM, Kilburn JD, Essex JW, Maurer RI, Blaydes JP, Agarwala U, Seabra LA.

Mol Cancer. 2011 Jun 13;10:72. doi: 10.1186/1476-4598-10-72.

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