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Antagonism of endogenous nociceptin/orphanin FQ inhibits infarction-associated ventricular arrhythmias via PKC-dependent mechanism in rats.

Han Y, Guo Z, Wang LL, Zhang LZ, Yao TP.

Br J Pharmacol. 2013 Oct;170(3):614-23. doi: 10.1111/bph.12310.


Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice.

Gavioli EC, Vaughan CW, Marzola G, Guerrini R, Mitchell VA, Zucchini S, De Lima TC, Rae GA, Salvadori S, Regoli D, Calo' G.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):547-53. Epub 2004 May 25.


[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

Calo G, Rizzi A, Rizzi D, Bigoni R, Guerrini R, Marzola G, Marti M, McDonald J, Morari M, Lambert DG, Salvadori S, Regoli D.

Br J Pharmacol. 2002 May;136(2):303-11.


Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.

Marti M, Mela F, Veronesi C, Guerrini R, Salvadori S, Federici M, Mercuri NB, Rizzi A, Franchi G, Beani L, Bianchi C, Morari M.

J Neurosci. 2004 Jul 28;24(30):6659-66.


Nociceptin/orphanin FQ modulates motor behavior and primary motor cortex output through receptors located in substantia nigra reticulata.

Marti M, Viaro R, Guerrini R, Franchi G, Morari M.

Neuropsychopharmacology. 2009 Jan;34(2):341-55. doi: 10.1038/npp.2008.56. Epub 2008 Apr 16.


Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis.

Petrella C, Giuli C, Broccardo M, Eutamene H, Cartier C, Leveque M, Bedini A, Spampinato S, Bueno L, Theodorou V, Improta G, Agostini S.

Pharmacol Res. 2013 Apr;70(1):72-9. doi: 10.1016/j.phrs.2013.01.004. Epub 2013 Jan 23.


[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.

CarrĂ  G, Rizzi A, Guerrini R, Barnes TA, McDonald J, Hebbes CP, Mela F, Kenigs VA, Marzola G, Rizzi D, Gavioli E, Zucchini S, Regoli D, Morari M, Salvadori S, Rowbotham DJ, Lambert DG, Kapusta DR, Calo' G.

J Pharmacol Exp Ther. 2005 Mar;312(3):1114-23. Epub 2004 Oct 27.


Binding of the novel radioligand [(3)H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptors.

Ibba M, Kitayama M, McDonald J, Calo G, Guerrini R, Farkas J, Toth G, Lambert DG.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):553-61. doi: 10.1007/s00210-008-0350-3. Epub 2008 Sep 21.


The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.

Brookes ZL, Stedman EN, Brown NJ, Hebbes CP, Guerrini R, Calo G, Reilly CS, Lambert DG.

PLoS One. 2013 Sep 23;8(9):e74943. doi: 10.1371/journal.pone.0074943. eCollection 2013.


Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation.

Leggett JD, Dawe KL, Jessop DS, Fulford AJ.

J Neuroendocrinol. 2009 Nov;21(11):888-97. doi: 10.1111/j.1365-2826.2009.01912.x. Epub 2009 Sep 1.


In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor.

Rizzi A, Spagnolo B, Wainford RD, Fischetti C, Guerrini R, Marzola G, Baldisserotto A, Salvadori S, Regoli D, Kapusta DR, Calo G.

Peptides. 2007 Jun;28(6):1240-51. Epub 2007 May 6.


Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats.

Delaney G, Dawe KL, Hogan R, Hunjan T, Roper J, Hazell G, Lolait SJ, Fulford AJ.

J Neuroendocrinol. 2012 Dec;24(12):1527-41. doi: 10.1111/j.1365-2826.2012.02361.x.


Quantitative study of [(pF)Phe4,Arg14,Lys15]nociceptin/orphanin FQ-NH2 (UFP-102) at NOP receptors in rat periaqueductal gray slices.

Kuo CJ, Liao YY, Guerrini R, Calo' G, Chiou LC.

Eur J Pharmacol. 2008 Jan 28;579(1-3):110-5. Epub 2007 Oct 11.


The gastric effects of UFP-112, a new nociceptin/orphanin receptor agonist, in physiological and pathological conditions.

Broccardo M, Guerrini R, Morini G, Polidori C, Agostini S, Petrella C, Improta G.

Peptides. 2007 Oct;28(10):1974-81. Epub 2007 Jul 27.

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