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Results: 1 to 20 of 160

1.

Design of novel Geldanamycin analogue hsp90 alpha-inhibitor in silico for breast cancer therapy.

Mahanta S, Pilla S, Paul S.

Med Hypotheses. 2013 Sep;81(3):463-9. doi: 10.1016/j.mehy.2013.06.012. Epub 2013 Jul 13.

PMID:
23860250
[PubMed - indexed for MEDLINE]
2.

In silico design of small peptide-based Hsp90 inhibitor: a novel anticancer agent.

Gupta UK, Mahanta S, Paul S.

Med Hypotheses. 2013 Nov;81(5):853-61. doi: 10.1016/j.mehy.2013.08.006. Epub 2013 Aug 23.

PMID:
24018284
[PubMed - indexed for MEDLINE]
3.

Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.

Stravopodis DJ, Margaritis LH, Voutsinas GE.

Curr Med Chem. 2007;14(29):3122-38. Review.

PMID:
18220746
[PubMed - indexed for MEDLINE]
4.

Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents.

Miyata Y.

Curr Pharm Des. 2005;11(9):1131-8. Review.

PMID:
15853661
[PubMed - indexed for MEDLINE]
5.

Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.

Krishnamoorthy GP, Guida T, Alfano L, Avilla E, Santoro M, Carlomagno F, Melillo RM.

J Biol Chem. 2013 Jun 14;288(24):17481-94. doi: 10.1074/jbc.M112.439422. Epub 2013 Apr 29.

PMID:
23629654
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inhibitors of the HSP90 molecular chaperone: current status.

Sharp S, Workman P.

Adv Cancer Res. 2006;95:323-48. Review.

PMID:
16860662
[PubMed - indexed for MEDLINE]
7.

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives.

Kim T, Keum G, Pae AN.

Expert Opin Ther Pat. 2013 Aug;23(8):919-43. doi: 10.1517/13543776.2013.780597. Epub 2013 May 4. Review.

PMID:
23641970
[PubMed - indexed for MEDLINE]
8.

Hsp90 chaperones wild-type p53 tumor suppressor protein.

Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M.

J Biol Chem. 2004 Nov 19;279(47):48836-45. Epub 2004 Sep 9.

PMID:
15358769
[PubMed - indexed for MEDLINE]
Free Article
9.

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.

Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH.

Mol Cell Biol. 1998 Mar;18(3):1517-24.

PMID:
9488468
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Hsp90: an emerging target for breast cancer therapy.

Beliakoff J, Whitesell L.

Anticancer Drugs. 2004 Aug;15(7):651-62. Review.

PMID:
15269596
[PubMed - indexed for MEDLINE]
11.

Associations of HSP90 client proteins in human breast cancer.

Shipp C, Watson K, Jones GL.

Anticancer Res. 2011 Jun;31(6):2095-101.

PMID:
21737627
[PubMed - indexed for MEDLINE]
12.

[Molecular chaperone HSP90 as a novel target for cancer chemotherapy].

Miyata Y.

Nihon Yakurigaku Zasshi. 2003 Jan;121(1):33-42. Review. Japanese.

PMID:
12617036
[PubMed - indexed for MEDLINE]
13.

The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.

Leng AM, Liu T, Yang J, Cui JF, Li XH, Zhu YN, Xiong T, Zhang G, Chen Y.

Cell Biol Int. 2012 Oct 1;36(10):893-9. doi: 10.1042/CBI20110473.

PMID:
22694478
[PubMed - indexed for MEDLINE]
14.

Potent cytotoxic C-11 modified geldanamycin analogues.

Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC, Liu Y.

J Med Chem. 2009 May 28;52(10):3265-73. doi: 10.1021/jm900098v.

PMID:
19405528
[PubMed - indexed for MEDLINE]
15.

Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors.

Powers MV, Workman P.

Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S125-35. Review.

PMID:
17259553
[PubMed - indexed for MEDLINE]
Free Article
16.

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

Schwock J, Pham NA, Cao MP, Hedley DW.

Cancer Chemother Pharmacol. 2008 Apr;61(4):669-81. Epub 2007 Jun 20.

PMID:
17579866
[PubMed - indexed for MEDLINE]
18.

Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.

Le Brazidec JY, Kamal A, Busch D, Thao L, Zhang L, Timony G, Grecko R, Trent K, Lough R, Salazar T, Khan S, Burrows F, Boehm MF.

J Med Chem. 2004 Jul 15;47(15):3865-73.

PMID:
15239664
[PubMed - indexed for MEDLINE]
19.

Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo.

Lang SA, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke MH, Dietmaier W, Bolder U, Schlitt HJ, Geissler EK, Stoeltzing O.

Mol Cancer Ther. 2007 Mar;6(3):1123-32.

PMID:
17363505
[PubMed - indexed for MEDLINE]
Free Article
20.

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

King FW, Wawrzynow A, Höhfeld J, Zylicz M.

EMBO J. 2001 Nov 15;20(22):6297-305.

PMID:
11707401
[PubMed - indexed for MEDLINE]
Free PMC Article

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