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A comparative study of PGI2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor.

Benyahia C, Boukais K, Gomez I, Silverstein A, Clapp L, Fabre A, Danel C, Leséche G, Longrois D, Norel X.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:48-55. doi: 10.1016/j.prostaglandins.2013.07.001. Epub 2013 Jul 12.


Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins.

Orie NN, Ledwozyw A, Williams DJ, Whittle BJ, Clapp LH.

Prostaglandins Other Lipid Mediat. 2013 Oct;106:1-7. doi: 10.1016/j.prostaglandins.2013.07.003. Epub 2013 Jul 18.


Prostanoid receptors involved in the relaxation of human pulmonary vessels.

Walch L, Labat C, Gascard JP, de Montpreville V, Brink C, Norel X.

Br J Pharmacol. 1999 Feb;126(4):859-66.


Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist.

Whittle BJ, Silverstein AM, Mottola DM, Clapp LH.

Biochem Pharmacol. 2012 Jul 1;84(1):68-75. doi: 10.1016/j.bcp.2012.03.012. Epub 2012 Mar 27.


Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.

Morrison K, Studer R, Ernst R, Haag F, Kauser K, Clozel M.

J Pharmacol Exp Ther. 2012 Dec;343(3):547-55. doi: 10.1124/jpet.112.197152. Epub 2012 Aug 23. Erratum in: J Pharmacol Exp Ther. 2013 Jan;344(1):317.


Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors.

Orie NN, Clapp LH.

Eur J Pharmacol. 2011 Mar 11;654(3):258-65. doi: 10.1016/j.ejphar.2010.12.005. Epub 2010 Dec 24.


Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents.

Benyahia C, Ozen G, Orie N, Ledwozyw A, Louedec L, Li F, Senbel AM, Silverstein A, Danel C, Longrois D, Clapp LH, Norel X, Topal G.

Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):46-52. doi: 10.1016/j.prostaglandins.2015.09.002. Epub 2015 Sep 8.


Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype.

Foudi N, Kotelevets L, Louedec L, Leséche G, Henin D, Chastre E, Norel X.

Br J Pharmacol. 2008 Aug;154(8):1631-9. doi: 10.1038/bjp.2008.214. Epub 2008 Jun 2.


Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery.

Jones RL, Qian YM, Wise H, Wong HN, Lam WL, Chan HW, Yim AP, Ho JK.

J Cardiovasc Pharmacol. 1997 Apr;29(4):525-35.


Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.

Lai YJ, Pullamsetti SS, Dony E, Weissmann N, Butrous G, Banat GA, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT.

Am J Respir Crit Care Med. 2008 Jul 15;178(2):188-96. doi: 10.1164/rccm.200710-1519OC. Epub 2008 May 8.


Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors.

Armstrong RA, Lawrence RA, Jones RL, Wilson NH, Collier A.

Br J Pharmacol. 1989 Jul;97(3):657-68.


Prostacyclin release and receptor activation: differential control of human pulmonary venous and arterial tone.

Norel X, Walch L, Gascard JP, deMontpreville V, Brink C.

Br J Pharmacol. 2004 Jun;142(4):788-96. Epub 2004 Jun 1.


Peroxisome proliferator-activated receptor-β/δ, the acute signaling factor in prostacyclin-induced pulmonary vasodilation.

Li Y, Connolly M, Nagaraj C, Tang B, Bálint Z, Popper H, Smolle-Juettner FM, Lindenmann J, Kwapiszewska G, Aaronson PI, Wohlkoenig C, Leithner K, Olschewski H, Olschewski A.

Am J Respir Cell Mol Biol. 2012 Mar;46(3):372-9. doi: 10.1165/rcmb.2010-0428OC. Epub 2011 Oct 20.


Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.

Morrison K, Ernst R, Hess P, Studer R, Clozel M.

J Pharmacol Exp Ther. 2010 Oct;335(1):249-55. doi: 10.1124/jpet.110.169748. Epub 2010 Jul 21.


Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins.

Walch L, de Montpreville V, Brink C, Norel X.

Br J Pharmacol. 2001 Dec;134(8):1671-8.


Effect of prostaglandin I2 analogs on macrophage inflammatory protein 1α in human monocytes via I prostanoid receptor and cyclic adenosine monophosphate.

Tsai MK, Hsieh CC, Kuo HF, Yang SN, Kuo CH, Huang MY, Tsai YM, Lee MS, Hung CH.

J Investig Med. 2014 Feb;62(2):332-9. doi: 10.231/JIM.0000000000000042.


The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors.

Clapp LH, Gurung R.

Prostaglandins Other Lipid Mediat. 2015 Jul;120:56-71. doi: 10.1016/j.prostaglandins.2015.04.007. Epub 2015 Apr 23. Review.

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